Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection

Retinoic acid and proteotoxic stress induce AML cell death overcoming stromal cell protection

Abstract Background Acute myeloid leukemia (AML) patients bearing the ITD mutation in the tyrosine kinase receptor FLT3 (FLT3-ITD) present a poor prognosis and a high risk of relapse. FLT3-ITD is retained in the endoplasmic reticulum (ER) and generates intrinsic proteotoxic stress. We devised a stra...

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Bibliographic Details
Main Authors: Francesca Liccardo, Martyna Śniegocka, Claudia Tito, Alessia Iaiza, Tiziana Ottone, Mariadomenica Divona, Serena Travaglini, Maurizio Mattei, Rosella Cicconi, Selenia Miglietta, Giuseppe Familiari, Stefania Annarita Nottola, Vincenzo Petrozza, Luca Tamagnone, Maria Teresa Voso, Silvia Masciarelli, Francesco Fazi
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
AML
Bone marrow stromal cells
Tumor microenvironment
Proteotoxic stress
ER stress
Oxidative stress
Online Access:https://doi.org/10.1186/s13046-023-02793-z

Internet

https://doi.org/10.1186/s13046-023-02793-z

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