Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models
Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies. During the aging process, senescent cell accumulation...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Aging |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2022.828058/full |
| _version_ | 1811232874213408768 |
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| author | Nurcan Inci Dilanur Kamali Erdogan Oguzhan Akyildiz Eda Tahir Turanli Eda Tahir Turanli Perinur Bozaykut Perinur Bozaykut |
| author_facet | Nurcan Inci Dilanur Kamali Erdogan Oguzhan Akyildiz Eda Tahir Turanli Eda Tahir Turanli Perinur Bozaykut Perinur Bozaykut |
| author_sort | Nurcan Inci |
| collection | DOAJ |
| description | Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies. During the aging process, senescent cell accumulation results in senescence-associated secretory phenotype (SASP) which plays an essential role in tissue dysfunction. Although discovered very recently, senotherapeutic drugs have been already involved in clinical studies. This review gives a summary of the molecular mechanisms of CS and its role particularly in the development of cardiovascular diseases (CVD) as the leading cause of death. In addition, it addresses alternative research tools including the nonhuman and human models as well as computational techniques for the discovery of novel therapies. Finally, senotherapeutic approaches that are mainly classified as senolytics and senomorphics are discussed. |
| first_indexed | 2024-04-12T11:11:43Z |
| format | Article |
| id | doaj.art-ce76ce6c7b634f2686442b4d1a125333 |
| institution | Directory Open Access Journal |
| issn | 2673-6217 |
| language | English |
| last_indexed | 2024-04-12T11:11:43Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging |
| spelling | doaj.art-ce76ce6c7b634f2686442b4d1a1253332022-12-22T03:35:36ZengFrontiers Media S.A.Frontiers in Aging2673-62172022-06-01310.3389/fragi.2022.828058828058Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and ModelsNurcan Inci0Dilanur Kamali1Erdogan Oguzhan Akyildiz2Eda Tahir Turanli3Eda Tahir Turanli4Perinur Bozaykut5Perinur Bozaykut6Graduate School of Natural and Applied Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, TurkeyGraduate School of Natural and Applied Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, TurkeyGraduate School of Natural and Applied Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, TurkeyGraduate School of Natural and Applied Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, TurkeyDepartment of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, TurkeyGraduate School of Natural and Applied Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, TurkeyDepartment of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, TurkeyIncreasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies. During the aging process, senescent cell accumulation results in senescence-associated secretory phenotype (SASP) which plays an essential role in tissue dysfunction. Although discovered very recently, senotherapeutic drugs have been already involved in clinical studies. This review gives a summary of the molecular mechanisms of CS and its role particularly in the development of cardiovascular diseases (CVD) as the leading cause of death. In addition, it addresses alternative research tools including the nonhuman and human models as well as computational techniques for the discovery of novel therapies. Finally, senotherapeutic approaches that are mainly classified as senolytics and senomorphics are discussed.https://www.frontiersin.org/articles/10.3389/fragi.2022.828058/fullCellular senescenceAgingSenotherapeuticsNaked mole-ratBlind mole-ratCardiovascular Diseases |
| spellingShingle | Nurcan Inci Dilanur Kamali Erdogan Oguzhan Akyildiz Eda Tahir Turanli Eda Tahir Turanli Perinur Bozaykut Perinur Bozaykut Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models Frontiers in Aging Cellular senescence Aging Senotherapeutics Naked mole-rat Blind mole-rat Cardiovascular Diseases |
| title | Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models |
| title_full | Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models |
| title_fullStr | Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models |
| title_full_unstemmed | Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models |
| title_short | Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models |
| title_sort | translation of cellular senescence to novel therapeutics insights from alternative tools and models |
| topic | Cellular senescence Aging Senotherapeutics Naked mole-rat Blind mole-rat Cardiovascular Diseases |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2022.828058/full |
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