Role of Dietary Flavonoids in Iron Homeostasis
Balancing systemic iron levels within narrow limits is critical for human health, as both iron deficiency and overload lead to serious disorders. There are no known physiologically controlled pathways to eliminate iron from the body and therefore iron homeostasis is maintained by modifying dietary i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/12/3/119 |
| _version_ | 1818561758493671424 |
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| author | Marija Lesjak Surjit K. S. Srai |
| author_facet | Marija Lesjak Surjit K. S. Srai |
| author_sort | Marija Lesjak |
| collection | DOAJ |
| description | Balancing systemic iron levels within narrow limits is critical for human health, as both iron deficiency and overload lead to serious disorders. There are no known physiologically controlled pathways to eliminate iron from the body and therefore iron homeostasis is maintained by modifying dietary iron absorption. Several dietary factors, such as flavonoids, are known to greatly affect iron absorption. Recent evidence suggests that flavonoids can affect iron status by regulating expression and activity of proteins involved the systemic regulation of iron metabolism and iron absorption. We provide an overview of the links between different dietary flavonoids and iron homeostasis together with the mechanism of flavonoids effect on iron metabolism. In addition, we also discuss the clinical relevance of state-of-the-art knowledge regarding therapeutic potential that flavonoids may have for conditions that are low in iron such as anaemia or iron overload diseases. |
| first_indexed | 2024-12-14T00:55:00Z |
| format | Article |
| id | doaj.art-ce76fb1b4ed442a78ed0209ad98a1550 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-12-14T00:55:00Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-ce76fb1b4ed442a78ed0209ad98a15502022-12-21T23:23:38ZengMDPI AGPharmaceuticals1424-82472019-08-0112311910.3390/ph12030119ph12030119Role of Dietary Flavonoids in Iron HomeostasisMarija Lesjak0Surjit K. S. Srai1Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21000 Novi Sad, SerbiaResearch Department of Structural and Molecular Biology, Division of Biosciences, University College London, Darwin Building, Gower Street, London WC1E 6BT, UKBalancing systemic iron levels within narrow limits is critical for human health, as both iron deficiency and overload lead to serious disorders. There are no known physiologically controlled pathways to eliminate iron from the body and therefore iron homeostasis is maintained by modifying dietary iron absorption. Several dietary factors, such as flavonoids, are known to greatly affect iron absorption. Recent evidence suggests that flavonoids can affect iron status by regulating expression and activity of proteins involved the systemic regulation of iron metabolism and iron absorption. We provide an overview of the links between different dietary flavonoids and iron homeostasis together with the mechanism of flavonoids effect on iron metabolism. In addition, we also discuss the clinical relevance of state-of-the-art knowledge regarding therapeutic potential that flavonoids may have for conditions that are low in iron such as anaemia or iron overload diseases.https://www.mdpi.com/1424-8247/12/3/119iron homeostasisiron absorptionnon-haem ironflavonoids |
| spellingShingle | Marija Lesjak Surjit K. S. Srai Role of Dietary Flavonoids in Iron Homeostasis Pharmaceuticals iron homeostasis iron absorption non-haem iron flavonoids |
| title | Role of Dietary Flavonoids in Iron Homeostasis |
| title_full | Role of Dietary Flavonoids in Iron Homeostasis |
| title_fullStr | Role of Dietary Flavonoids in Iron Homeostasis |
| title_full_unstemmed | Role of Dietary Flavonoids in Iron Homeostasis |
| title_short | Role of Dietary Flavonoids in Iron Homeostasis |
| title_sort | role of dietary flavonoids in iron homeostasis |
| topic | iron homeostasis iron absorption non-haem iron flavonoids |
| url | https://www.mdpi.com/1424-8247/12/3/119 |
| work_keys_str_mv | AT marijalesjak roleofdietaryflavonoidsinironhomeostasis AT surjitkssrai roleofdietaryflavonoidsinironhomeostasis |