The evolution of antibiotic susceptibility and resistance during the formation of <it>Escherichia coli</it> biofilms in the absence of antibiotics
<p>Abstract</p> <p>Background</p> <p>Explanations for bacterial biofilm persistence during antibiotic treatment typically depend on non-genetic mechanisms, and rarely consider the contribution of evolutionary processes.</p> <p>Results</p> <p>Usin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2013-01-01
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| Series: | BMC Evolutionary Biology |
| Subjects: | |
| Online Access: | http://www.biomedcentral.com/1471-2148/13/22 |
| _version_ | 1798029197826850816 |
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| author | Tyerman Jabus G Ponciano José M Joyce Paul Forney Larry J Harmon Luke J |
| author_facet | Tyerman Jabus G Ponciano José M Joyce Paul Forney Larry J Harmon Luke J |
| author_sort | Tyerman Jabus G |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Explanations for bacterial biofilm persistence during antibiotic treatment typically depend on non-genetic mechanisms, and rarely consider the contribution of evolutionary processes.</p> <p>Results</p> <p>Using <it>Escherichia coli</it> biofilms, we demonstrate that heritable variation for broad-spectrum antibiotic resistance can arise and accumulate rapidly during biofilm development, even in the absence of antibiotic selection.</p> <p>Conclusions</p> <p>Our results demonstrate the rapid <it>de novo</it> evolution of heritable variation in antibiotic sensitivity and resistance during <it>E. coli</it> biofilm development. We suggest that evolutionary processes, whether genetic drift or natural selection, should be considered as a factor to explain the elevated tolerance to antibiotics typically observed in bacterial biofilms. This could be an under-appreciated mechanism that accounts why biofilm populations are, in general, highly resistant to antibiotic treatment.</p> |
| first_indexed | 2024-04-11T19:20:25Z |
| format | Article |
| id | doaj.art-ce772418e0664bd38d0919aa59b6387f |
| institution | Directory Open Access Journal |
| issn | 1471-2148 |
| language | English |
| last_indexed | 2024-04-11T19:20:25Z |
| publishDate | 2013-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Evolutionary Biology |
| spelling | doaj.art-ce772418e0664bd38d0919aa59b6387f2022-12-22T04:07:19ZengBMCBMC Evolutionary Biology1471-21482013-01-011312210.1186/1471-2148-13-22The evolution of antibiotic susceptibility and resistance during the formation of <it>Escherichia coli</it> biofilms in the absence of antibioticsTyerman Jabus GPonciano José MJoyce PaulForney Larry JHarmon Luke J<p>Abstract</p> <p>Background</p> <p>Explanations for bacterial biofilm persistence during antibiotic treatment typically depend on non-genetic mechanisms, and rarely consider the contribution of evolutionary processes.</p> <p>Results</p> <p>Using <it>Escherichia coli</it> biofilms, we demonstrate that heritable variation for broad-spectrum antibiotic resistance can arise and accumulate rapidly during biofilm development, even in the absence of antibiotic selection.</p> <p>Conclusions</p> <p>Our results demonstrate the rapid <it>de novo</it> evolution of heritable variation in antibiotic sensitivity and resistance during <it>E. coli</it> biofilm development. We suggest that evolutionary processes, whether genetic drift or natural selection, should be considered as a factor to explain the elevated tolerance to antibiotics typically observed in bacterial biofilms. This could be an under-appreciated mechanism that accounts why biofilm populations are, in general, highly resistant to antibiotic treatment.</p>http://www.biomedcentral.com/1471-2148/13/22EvolutionAntibiotic resistanceBacterial biofilmsMutationsDiversity |
| spellingShingle | Tyerman Jabus G Ponciano José M Joyce Paul Forney Larry J Harmon Luke J The evolution of antibiotic susceptibility and resistance during the formation of <it>Escherichia coli</it> biofilms in the absence of antibiotics BMC Evolutionary Biology Evolution Antibiotic resistance Bacterial biofilms Mutations Diversity |
| title | The evolution of antibiotic susceptibility and resistance during the formation of <it>Escherichia coli</it> biofilms in the absence of antibiotics |
| title_full | The evolution of antibiotic susceptibility and resistance during the formation of <it>Escherichia coli</it> biofilms in the absence of antibiotics |
| title_fullStr | The evolution of antibiotic susceptibility and resistance during the formation of <it>Escherichia coli</it> biofilms in the absence of antibiotics |
| title_full_unstemmed | The evolution of antibiotic susceptibility and resistance during the formation of <it>Escherichia coli</it> biofilms in the absence of antibiotics |
| title_short | The evolution of antibiotic susceptibility and resistance during the formation of <it>Escherichia coli</it> biofilms in the absence of antibiotics |
| title_sort | evolution of antibiotic susceptibility and resistance during the formation of it escherichia coli it biofilms in the absence of antibiotics |
| topic | Evolution Antibiotic resistance Bacterial biofilms Mutations Diversity |
| url | http://www.biomedcentral.com/1471-2148/13/22 |
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