Interaction between retinol intake and ISX rs5755368 polymorphism in colorectal cancer risk: a case–control study in a Korean population
Abstract This study aimed to examine whether the ISX rs5755368 genotypes are associated with the effect of dietary retinol consumption on CRC risk. We recruited 923 CRC patients and 1846 controls to identify the association between dietary retinol and CRC risk. Dietary retinol intake was assessed us...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-36973-w |
| _version_ | 1797795740776398848 |
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| author | Anh Quynh Bui Madhawa Gunathilake Jeonghee Lee Jae Hwan Oh Hee Jin Chang Dae Kyung Sohn Aesun Shin Jeongseon Kim |
| author_facet | Anh Quynh Bui Madhawa Gunathilake Jeonghee Lee Jae Hwan Oh Hee Jin Chang Dae Kyung Sohn Aesun Shin Jeongseon Kim |
| author_sort | Anh Quynh Bui |
| collection | DOAJ |
| description | Abstract This study aimed to examine whether the ISX rs5755368 genotypes are associated with the effect of dietary retinol consumption on CRC risk. We recruited 923 CRC patients and 1846 controls to identify the association between dietary retinol and CRC risk. Dietary retinol intake was assessed using a semiquantitative food frequency questionnaire. Genotype data were available for 1419 patients (600 cases and 819 controls) of the total study population. Genotyping was performed using an Illumina MEGA Expanded Array. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression models. Retinol intake was inversely associated with CRC (OR = 0.49; 95% CI = 0.37–0.63). Participants with AA genotype showed lower CRC risk than subjects carrying the G allele (AG + GG) (OR = 0.76; 95% CI = 0.58–0.99). A 68% reduced risk of CRC was related to subjects who had the highest retinol intake and carrying AA genotype compared to the risk of participants consumed the lowest retinol intake and carrying the G allele (OR = 0.32; 95% CI = 0.20–0.53; P interaction = 0.026). Retinol intake could be a protective factor for CRC risk while this association could be strengthened among individuals carrying the homozygous AA genotype. |
| first_indexed | 2024-03-13T03:22:36Z |
| format | Article |
| id | doaj.art-ce7809faee9f44f6bbaf7c576f6549c9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T03:22:36Z |
| publishDate | 2023-06-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-ce7809faee9f44f6bbaf7c576f6549c92023-06-25T11:15:40ZengNature PortfolioScientific Reports2045-23222023-06-011311910.1038/s41598-023-36973-wInteraction between retinol intake and ISX rs5755368 polymorphism in colorectal cancer risk: a case–control study in a Korean populationAnh Quynh Bui0Madhawa Gunathilake1Jeonghee Lee2Jae Hwan Oh3Hee Jin Chang4Dae Kyung Sohn5Aesun Shin6Jeongseon Kim7Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer CenterDepartment of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer CenterDepartment of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer CenterCenter for Colorectal Cancer, National Cancer Center Hospital, National Cancer CenterCenter for Colorectal Cancer, National Cancer Center Hospital, National Cancer CenterCenter for Colorectal Cancer, National Cancer Center Hospital, National Cancer CenterDepartment of Preventive Medicine, Seoul National University College of MedicineDepartment of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer CenterAbstract This study aimed to examine whether the ISX rs5755368 genotypes are associated with the effect of dietary retinol consumption on CRC risk. We recruited 923 CRC patients and 1846 controls to identify the association between dietary retinol and CRC risk. Dietary retinol intake was assessed using a semiquantitative food frequency questionnaire. Genotype data were available for 1419 patients (600 cases and 819 controls) of the total study population. Genotyping was performed using an Illumina MEGA Expanded Array. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression models. Retinol intake was inversely associated with CRC (OR = 0.49; 95% CI = 0.37–0.63). Participants with AA genotype showed lower CRC risk than subjects carrying the G allele (AG + GG) (OR = 0.76; 95% CI = 0.58–0.99). A 68% reduced risk of CRC was related to subjects who had the highest retinol intake and carrying AA genotype compared to the risk of participants consumed the lowest retinol intake and carrying the G allele (OR = 0.32; 95% CI = 0.20–0.53; P interaction = 0.026). Retinol intake could be a protective factor for CRC risk while this association could be strengthened among individuals carrying the homozygous AA genotype.https://doi.org/10.1038/s41598-023-36973-w |
| spellingShingle | Anh Quynh Bui Madhawa Gunathilake Jeonghee Lee Jae Hwan Oh Hee Jin Chang Dae Kyung Sohn Aesun Shin Jeongseon Kim Interaction between retinol intake and ISX rs5755368 polymorphism in colorectal cancer risk: a case–control study in a Korean population Scientific Reports |
| title | Interaction between retinol intake and ISX rs5755368 polymorphism in colorectal cancer risk: a case–control study in a Korean population |
| title_full | Interaction between retinol intake and ISX rs5755368 polymorphism in colorectal cancer risk: a case–control study in a Korean population |
| title_fullStr | Interaction between retinol intake and ISX rs5755368 polymorphism in colorectal cancer risk: a case–control study in a Korean population |
| title_full_unstemmed | Interaction between retinol intake and ISX rs5755368 polymorphism in colorectal cancer risk: a case–control study in a Korean population |
| title_short | Interaction between retinol intake and ISX rs5755368 polymorphism in colorectal cancer risk: a case–control study in a Korean population |
| title_sort | interaction between retinol intake and isx rs5755368 polymorphism in colorectal cancer risk a case control study in a korean population |
| url | https://doi.org/10.1038/s41598-023-36973-w |
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