Binding symmetry and surface flexibility mediate antibody self-association

Binding symmetry and surface flexibility mediate antibody self-association

Solution stability is an important factor in the optimization of engineered biotherapeutic candidates such as monoclonal antibodies because of its possible effects on manufacturability, pharmacology, efficacy and safety. A detailed atomic understanding of the mechanisms governing self-association of...

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Bibliographic Details
Main Authors: Joseph D. Schrag, Marie-Ève Picard, Francis Gaudreault, Louis-Patrick Gagnon, Jason Baardsnes, Mahder S. Manenda, Joey Sheff, Christophe Deprez, Cassio Baptista, Hervé Hogues, John F. Kelly, Enrico O. Purisima, Rong Shi, Traian Sulea
Format: Article
Language:English
Published: Taylor & Francis Group 2019-10-01
Series:mAbs
Subjects:
Aggregation
native folding
single point mutation
structure-aggregation relationship
prediction method
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2019.1632114

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