Altered Blood–Brain Barrier Dynamics in the C9orf72 Hexanucleotide Repeat Expansion Mouse Model of Amyotrophic Lateral Sclerosis

Altered Blood–Brain Barrier Dynamics in the C9orf72 Hexanucleotide Repeat Expansion Mouse Model of Amyotrophic Lateral Sclerosis

For peripherally administered drugs to reach the central nervous system (CNS) and treat amyotrophic lateral sclerosis (ALS), they must cross the blood–brain barrier (BBB). As mounting evidence suggests that the ultrastructure of the BBB is altered in individuals with ALS and in animal models of ALS...

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Hlavní autoři: Yijun Pan, Yoshiteru Kagawa, Jiaqi Sun, Bradley J. Turner, Cheng Huang, Anup D. Shah, Ralf B. Schittenhelm, Joseph A. Nicolazzo
Médium: Článek
Jazyk:English
Vydáno: MDPI AG 2022-12-01
Edice:Pharmaceutics
Témata:
amyotrophic lateral sclerosis
blood–brain barrier
brain microvascular endothelial cells
C9orf72 gene
proteomics
On-line přístup:https://www.mdpi.com/1999-4923/14/12/2803

Internet

https://www.mdpi.com/1999-4923/14/12/2803

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