Altered Blood–Brain Barrier Dynamics in the C9orf72 Hexanucleotide Repeat Expansion Mouse Model of Amyotrophic Lateral Sclerosis

Altered Blood–Brain Barrier Dynamics in the C9orf72 Hexanucleotide Repeat Expansion Mouse Model of Amyotrophic Lateral Sclerosis

For peripherally administered drugs to reach the central nervous system (CNS) and treat amyotrophic lateral sclerosis (ALS), they must cross the blood–brain barrier (BBB). As mounting evidence suggests that the ultrastructure of the BBB is altered in individuals with ALS and in animal models of ALS...

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Detalles Bibliográficos
Autores principales: Yijun Pan, Yoshiteru Kagawa, Jiaqi Sun, Bradley J. Turner, Cheng Huang, Anup D. Shah, Ralf B. Schittenhelm, Joseph A. Nicolazzo
Formato: Artículo
Lenguaje:English
Publicado: MDPI AG 2022-12-01
Colección:Pharmaceutics
Materias:
amyotrophic lateral sclerosis
blood–brain barrier
brain microvascular endothelial cells
C9orf72 gene
proteomics
Acceso en línea:https://www.mdpi.com/1999-4923/14/12/2803

Internet

https://www.mdpi.com/1999-4923/14/12/2803

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