Total number of reads affects the accuracy of fetal fraction estimates in NIPT

Total number of reads affects the accuracy of fetal fraction estimates in NIPT

ABSTRACT Background Sufficient fetal fraction (FF) is crucial for quality control of NIPT (Non‐Invasive Prenatal Test) results. Different factors influencing bioinformatic estimation of FF should be considered when implementing NIPT. To what extent the total number of sequencing reads influences FF...

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Bibliographic Details
Main Authors: Ieva Miceikaitė, Charlotte Brasch‐Andersen, Christina Fagerberg, Martin Jakob Larsen
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
cell‐free DNA
circulating fetal DNA
fetal fraction
NIPT
prenatal diagnosis
Online Access:https://doi.org/10.1002/mgg3.1653

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