Levels of Serum Selenium and Zinc in Critically ill Type 2 Diabetics and Normal Healthy Individuals at Tertiary Care Hospital, Surat, India
Introduction: Type 2 Diabetes Mellitus (T2DM), accounting for 85-90% of diabetic subjects globally, is reported to be also caused by imbalance between pro-oxidant and antioxidant factors. This very fact necessitates exploring and evaluating the possibilities of role of various antioxidant trace...
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JCDR Research and Publications Pvt. Ltd.
2022-01-01
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| Series: | National Journal of Laboratory Medicine |
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| Online Access: | https://www.njlm.net/articles/PDF/2574/51859_CE[Ra1]_F(SHU)_PF1(AKA_SS)_PN(SHU).pdf |
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| author | Sheetalkumari Paresh Patel DVSS Ramavataram N Chandrika Hasitkumar Dalpatbhai Lad |
| author_facet | Sheetalkumari Paresh Patel DVSS Ramavataram N Chandrika Hasitkumar Dalpatbhai Lad |
| author_sort | Sheetalkumari Paresh Patel |
| collection | DOAJ |
| description | Introduction: Type 2 Diabetes Mellitus (T2DM), accounting for
85-90% of diabetic subjects globally, is reported to be also
caused by imbalance between pro-oxidant and antioxidant
factors. This very fact necessitates exploring and evaluating the
possibilities of role of various antioxidant trace elements like
selenium and zinc, in further understanding the pathogenesis and
appropriate applicable intervention required, if any for patients
suffering from diabetes mellitus. The levels of trace elements like
selenium and zinc, representing antioxidant capacity, might be
implicated in development of type II diabetes and vice versa.
Aim: To evaluate the levels of serum selenium and zinc in
critically ill type 2 diabetic patients and comparing them with
healthy individuals.
Materials and Methods: This case-control study was conducted
for a period of nine months from October 2016 to June 2017. Fifty
critically ill type 2 diabetic patients and 150 apparently healthy age
and gender matched controls were recruited into this study. Serum
selenium and zinc levels were estimated in subjects of both the
groups. Mean, standard deviation, Analysis of Variance (ANOVA) test
and student t-test were statistical tools used to interpret the results.
Results: Fifty critically ill T2DM patients constituted the cases
and 150 age and sex matched healthy adults were in the control
group. Mean Random Blood Sugar (RBS) in controls was
113.14±25.52 mg/dL while in that in cases was 246.48±98 mg/dL
and the difference was significant (p-value <0.01). This study
showed significant difference (p<0.01) in the level of serum
selenium and zinc levels in critically ill diabetic patients compared
to healthy individuals across all age groups i.e., <40, 40 to 55 and
>55 years. The mean level of selenium in cases and controls were
83.8±11.97 and 103.08±67.7 μg/dL (p-value <0.01) respectively.
The mean level of zinc amongst cases and controls were
40.83±21.19 and 103.08±67.7 (p-value <0.01), respectively.
Conclusion: Serum selenium and zinc levels were decreased
in critically ill type 2 diabetic patients owing to the increased
production of free radicals in them. Supplementation of selenium
and zinc in these individuals could be beneficial and is therefore
recommended. |
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| spelling | doaj.art-ce7b99db2ca6457bb7cbefaec5a9cbc12022-12-21T18:20:03ZengJCDR Research and Publications Pvt. Ltd.National Journal of Laboratory Medicine2277-85512455-68822022-01-011101202310.7860/NJLM/2022/51859.2574Levels of Serum Selenium and Zinc in Critically ill Type 2 Diabetics and Normal Healthy Individuals at Tertiary Care Hospital, Surat, IndiaSheetalkumari Paresh Patel0DVSS Ramavataram1N Chandrika2 Hasitkumar Dalpatbhai Lad3Tutor, Department of Biochemistry, Surat Municipal Institute of Medical Education and Research, Surat, Gujarat, India.Professor, Department of Biochemistry, Smt. B. K. Shah Medical Institute and Research Centre and Dhiraj Hospital, Vadodara, Gujarat, IndiaAssociate Professor, Department of Biochemistry, Chamarajanagar Institute of Medical Sciences, Chamarajanagar, Karnataka, India.Associate Professor, Department of Biochemistry, Surat Municipal Institute of Medical Education and Research, Surat, Gujarat, IndiaIntroduction: Type 2 Diabetes Mellitus (T2DM), accounting for 85-90% of diabetic subjects globally, is reported to be also caused by imbalance between pro-oxidant and antioxidant factors. This very fact necessitates exploring and evaluating the possibilities of role of various antioxidant trace elements like selenium and zinc, in further understanding the pathogenesis and appropriate applicable intervention required, if any for patients suffering from diabetes mellitus. The levels of trace elements like selenium and zinc, representing antioxidant capacity, might be implicated in development of type II diabetes and vice versa. Aim: To evaluate the levels of serum selenium and zinc in critically ill type 2 diabetic patients and comparing them with healthy individuals. Materials and Methods: This case-control study was conducted for a period of nine months from October 2016 to June 2017. Fifty critically ill type 2 diabetic patients and 150 apparently healthy age and gender matched controls were recruited into this study. Serum selenium and zinc levels were estimated in subjects of both the groups. Mean, standard deviation, Analysis of Variance (ANOVA) test and student t-test were statistical tools used to interpret the results. Results: Fifty critically ill T2DM patients constituted the cases and 150 age and sex matched healthy adults were in the control group. Mean Random Blood Sugar (RBS) in controls was 113.14±25.52 mg/dL while in that in cases was 246.48±98 mg/dL and the difference was significant (p-value <0.01). This study showed significant difference (p<0.01) in the level of serum selenium and zinc levels in critically ill diabetic patients compared to healthy individuals across all age groups i.e., <40, 40 to 55 and >55 years. The mean level of selenium in cases and controls were 83.8±11.97 and 103.08±67.7 μg/dL (p-value <0.01) respectively. The mean level of zinc amongst cases and controls were 40.83±21.19 and 103.08±67.7 (p-value <0.01), respectively. Conclusion: Serum selenium and zinc levels were decreased in critically ill type 2 diabetic patients owing to the increased production of free radicals in them. Supplementation of selenium and zinc in these individuals could be beneficial and is therefore recommended.https://www.njlm.net/articles/PDF/2574/51859_CE[Ra1]_F(SHU)_PF1(AKA_SS)_PN(SHU).pdfantioxidantoxidative stresstrace mineralstherapeutic supplementation |
| spellingShingle | Sheetalkumari Paresh Patel DVSS Ramavataram N Chandrika Hasitkumar Dalpatbhai Lad Levels of Serum Selenium and Zinc in Critically ill Type 2 Diabetics and Normal Healthy Individuals at Tertiary Care Hospital, Surat, India National Journal of Laboratory Medicine antioxidant oxidative stress trace minerals therapeutic supplementation |
| title | Levels of Serum Selenium and Zinc in Critically ill Type 2 Diabetics and Normal Healthy Individuals at Tertiary Care Hospital, Surat, India |
| title_full | Levels of Serum Selenium and Zinc in Critically ill Type 2 Diabetics and Normal Healthy Individuals at Tertiary Care Hospital, Surat, India |
| title_fullStr | Levels of Serum Selenium and Zinc in Critically ill Type 2 Diabetics and Normal Healthy Individuals at Tertiary Care Hospital, Surat, India |
| title_full_unstemmed | Levels of Serum Selenium and Zinc in Critically ill Type 2 Diabetics and Normal Healthy Individuals at Tertiary Care Hospital, Surat, India |
| title_short | Levels of Serum Selenium and Zinc in Critically ill Type 2 Diabetics and Normal Healthy Individuals at Tertiary Care Hospital, Surat, India |
| title_sort | levels of serum selenium and zinc in critically ill type 2 diabetics and normal healthy individuals at tertiary care hospital surat india |
| topic | antioxidant oxidative stress trace minerals therapeutic supplementation |
| url | https://www.njlm.net/articles/PDF/2574/51859_CE[Ra1]_F(SHU)_PF1(AKA_SS)_PN(SHU).pdf |
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