Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency
Gpr125 has emerged as a specific marker of mammary stem cells and basal progenitors. Here they show that Gpr125 cells congregate at ductal tips during morphogenesis and amass at tumor margins, and that high Gpr125 predicts early tumor onset and poor outcome in basal breast cancer.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28937-x |
| _version_ | 1811273512785018880 |
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| author | Elena Spina Julia Simundza Angela Incassati Anupama Chandramouli Matthias C. Kugler Ziyan Lin Alireza Khodadadi-Jamayran Christine J. Watson Pamela Cowin |
| author_facet | Elena Spina Julia Simundza Angela Incassati Anupama Chandramouli Matthias C. Kugler Ziyan Lin Alireza Khodadadi-Jamayran Christine J. Watson Pamela Cowin |
| author_sort | Elena Spina |
| collection | DOAJ |
| description | Gpr125 has emerged as a specific marker of mammary stem cells and basal progenitors. Here they show that Gpr125 cells congregate at ductal tips during morphogenesis and amass at tumor margins, and that high Gpr125 predicts early tumor onset and poor outcome in basal breast cancer. |
| first_indexed | 2024-04-12T23:00:36Z |
| format | Article |
| id | doaj.art-ce7bc99fa1f146eabcbf6f7745f6c135 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T23:00:36Z |
| publishDate | 2022-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ce7bc99fa1f146eabcbf6f7745f6c1352022-12-22T03:13:04ZengNature PortfolioNature Communications2041-17232022-03-0113111710.1038/s41467-022-28937-xGpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latencyElena Spina0Julia Simundza1Angela Incassati2Anupama Chandramouli3Matthias C. Kugler4Ziyan Lin5Alireza Khodadadi-Jamayran6Christine J. Watson7Pamela Cowin8Department of Cell Biology, New York University School of MedicineDepartment of Cell Biology, New York University School of MedicineDepartment of Cell Biology, New York University School of MedicineDepartment of Cell Biology, New York University School of MedicineDivision of Pulmonary and Critical Care Medicine, New York University School of MedicineDepartment of Applied Bioinformatics, New York University School of MedicineDepartment of Applied Bioinformatics, New York University School of MedicineDepartment of Pathology, University of CambridgeDepartment of Cell Biology, New York University School of MedicineGpr125 has emerged as a specific marker of mammary stem cells and basal progenitors. Here they show that Gpr125 cells congregate at ductal tips during morphogenesis and amass at tumor margins, and that high Gpr125 predicts early tumor onset and poor outcome in basal breast cancer.https://doi.org/10.1038/s41467-022-28937-x |
| spellingShingle | Elena Spina Julia Simundza Angela Incassati Anupama Chandramouli Matthias C. Kugler Ziyan Lin Alireza Khodadadi-Jamayran Christine J. Watson Pamela Cowin Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency Nature Communications |
| title | Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency |
| title_full | Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency |
| title_fullStr | Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency |
| title_full_unstemmed | Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency |
| title_short | Gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency |
| title_sort | gpr125 is a unifying hallmark of multiple mammary progenitors coupled to tumor latency |
| url | https://doi.org/10.1038/s41467-022-28937-x |
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