Progression of chronic kidney disease in non- dialysis patients: a retrospective cohort
Abstract Evidence on factors associated with the progression of chronic kidney disease (CKD) is still under construction. The present study aimed to evaluate sociodemographic, clinical, and drug use factors associated with the progression of CKD. A retrospective cohort study was conducted with 193 p...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2022-11-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100736&lng=en&tlng=en |
| _version_ | 1828130292622163968 |
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| author | Jéssica Azevedo Aquino Cláudia Lorenzo Oliveira Alba Otoni Cristina Sanches João Victor Marques Guedes Diego Bruno Morais Thays Santos Mendonça Flávio Augusto Morais André Oliveira Baldoni |
| author_facet | Jéssica Azevedo Aquino Cláudia Lorenzo Oliveira Alba Otoni Cristina Sanches João Victor Marques Guedes Diego Bruno Morais Thays Santos Mendonça Flávio Augusto Morais André Oliveira Baldoni |
| author_sort | Jéssica Azevedo Aquino |
| collection | DOAJ |
| description | Abstract Evidence on factors associated with the progression of chronic kidney disease (CKD) is still under construction. The present study aimed to evaluate sociodemographic, clinical, and drug use factors associated with the progression of CKD. A retrospective cohort study was conducted with 193 patients with CKD stages 3A to 5- non-dialysis followed for three years in a Brazilian city. The outcome was the evolution to renal replacement therapy (RRT) or death. A total of 52.3 % (n = 101) were men and 83.4 % (n = 161) elderly. The median age was 72.0 years, and 22.3 % (n = 44) progressed to RRT or death, and the three-year mortality rate was 20.2 %. Participants exposed to angiotensin converting enzyme inhibitors or angiotensin II receptor blockers had a lower risk of progressing to the outcome (hazard ratio (HR) 0.25; p = 0.003) and higher survival (p = 0.022) when compared to those not exposed to these drugs. Age (HR 1.06;) and use of omeprazole (HR 6.25; CI; p <0.01) and hydrochlorothiazide (HR 2.80; p = 0.028) increased the risks of RRT or death. The results highlight the importance of rational management of pharmacotherapy for patients with CKD. |
| first_indexed | 2024-04-11T16:30:45Z |
| format | Article |
| id | doaj.art-ce7ed2a8be0b46b4ae8c80a1ac7e7384 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-11T16:30:45Z |
| publishDate | 2022-11-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-ce7ed2a8be0b46b4ae8c80a1ac7e73842022-12-22T04:14:02ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902022-11-015810.1590/s2175-97902022e20249Progression of chronic kidney disease in non- dialysis patients: a retrospective cohortJéssica Azevedo AquinoCláudia Lorenzo OliveiraAlba OtoniCristina SanchesJoão Victor Marques Guedeshttps://orcid.org/0000-0002-4812-7030Diego Bruno MoraisThays Santos Mendonçahttps://orcid.org/0000-0002-7005-8780Flávio Augusto MoraisAndré Oliveira Baldonihttps://orcid.org/0000-0001-6379-0415Abstract Evidence on factors associated with the progression of chronic kidney disease (CKD) is still under construction. The present study aimed to evaluate sociodemographic, clinical, and drug use factors associated with the progression of CKD. A retrospective cohort study was conducted with 193 patients with CKD stages 3A to 5- non-dialysis followed for three years in a Brazilian city. The outcome was the evolution to renal replacement therapy (RRT) or death. A total of 52.3 % (n = 101) were men and 83.4 % (n = 161) elderly. The median age was 72.0 years, and 22.3 % (n = 44) progressed to RRT or death, and the three-year mortality rate was 20.2 %. Participants exposed to angiotensin converting enzyme inhibitors or angiotensin II receptor blockers had a lower risk of progressing to the outcome (hazard ratio (HR) 0.25; p = 0.003) and higher survival (p = 0.022) when compared to those not exposed to these drugs. Age (HR 1.06;) and use of omeprazole (HR 6.25; CI; p <0.01) and hydrochlorothiazide (HR 2.80; p = 0.028) increased the risks of RRT or death. The results highlight the importance of rational management of pharmacotherapy for patients with CKD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100736&lng=en&tlng=enChronic kidney diseaseDisease progressionDrug utilizationDrug therapyNephrology |
| spellingShingle | Jéssica Azevedo Aquino Cláudia Lorenzo Oliveira Alba Otoni Cristina Sanches João Victor Marques Guedes Diego Bruno Morais Thays Santos Mendonça Flávio Augusto Morais André Oliveira Baldoni Progression of chronic kidney disease in non- dialysis patients: a retrospective cohort Brazilian Journal of Pharmaceutical Sciences Chronic kidney disease Disease progression Drug utilization Drug therapy Nephrology |
| title | Progression of chronic kidney disease in non- dialysis patients: a retrospective cohort |
| title_full | Progression of chronic kidney disease in non- dialysis patients: a retrospective cohort |
| title_fullStr | Progression of chronic kidney disease in non- dialysis patients: a retrospective cohort |
| title_full_unstemmed | Progression of chronic kidney disease in non- dialysis patients: a retrospective cohort |
| title_short | Progression of chronic kidney disease in non- dialysis patients: a retrospective cohort |
| title_sort | progression of chronic kidney disease in non dialysis patients a retrospective cohort |
| topic | Chronic kidney disease Disease progression Drug utilization Drug therapy Nephrology |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100736&lng=en&tlng=en |
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