Anti-Hypertensive Activity of Novel Peptides Identified from Olive Flounder (<i>Paralichthys olivaceus</i>) Surimi
There is a growing interest in the health benefits of functional foods. A benefit that has been long sought is the control of hypertension through dietary approaches. Hypertension has been implicated as a risk factor for cardiovascular disease and is therefore of clinical significance. Here, we aim...
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| Format: | Article |
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MDPI AG
2020-05-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/9/5/647 |
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| author | Jae-Young Oh Jun-Geon Je Hyo-Geun Lee Eun-A Kim Sang In Kang Jung-Suck Lee You-Jin Jeon |
| author_facet | Jae-Young Oh Jun-Geon Je Hyo-Geun Lee Eun-A Kim Sang In Kang Jung-Suck Lee You-Jin Jeon |
| author_sort | Jae-Young Oh |
| collection | DOAJ |
| description | There is a growing interest in the health benefits of functional foods. A benefit that has been long sought is the control of hypertension through dietary approaches. Hypertension has been implicated as a risk factor for cardiovascular disease and is therefore of clinical significance. Here, we aim to demonstrate the antihypertensive activity of novel peptides derived from surimi, a functional food ingredient made from refined fish myofibrillar proteins. Three peptides, Ile-Val-Asp-Arg (IVDR), Trp-Tyr-Lys (WYK), and Val-Ala-Ser-Val-Ile (VASVI), were isolated from surimi made from the olive flounder (<i>Paralichthys olivaceus</i>). Our results show that IVDR, WYK, and VASVI exhibited high Angiotensin I-converting Enzyme (ACE) inhibition activity. These peptides are also shown to increase phosphorylation of protein kinase B (Akt) and endothelial nitric oxide synthase (eNOS), and significantly promote nitric oxide (NO) production in human umbilical vein endothelial cells. Oral administration of the peptides decreased blood pressure in spontaneously hypertensive rats (SHRs), thereby confirming that the peptides derived from surimi perform antihypertensive activity via the Akt/eNOS pathway. These results indicate that surimi made from <i>P. olivaceus</i> contains novel antihypertensive peptides that could be used to enhance the health benefits of food ingredients. |
| first_indexed | 2024-03-10T19:46:06Z |
| format | Article |
| id | doaj.art-ce7fa978d0d54f4ba78a512f576b2e5a |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T19:46:06Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-ce7fa978d0d54f4ba78a512f576b2e5a2023-11-20T00:47:57ZengMDPI AGFoods2304-81582020-05-019564710.3390/foods9050647Anti-Hypertensive Activity of Novel Peptides Identified from Olive Flounder (<i>Paralichthys olivaceus</i>) SurimiJae-Young Oh0Jun-Geon Je1Hyo-Geun Lee2Eun-A Kim3Sang In Kang4Jung-Suck Lee5You-Jin Jeon6Department of Marine Life Science, Jeju National University, Jeju 63243, KoreaDepartment of Marine Life Science, Jeju National University, Jeju 63243, KoreaDepartment of Marine Life Science, Jeju National University, Jeju 63243, KoreaJeju International Marine Science Center for Research & Education, Korea Institute of Ocean Science and Technology, Jeju 63349, KoreaDepartment of Seafood and Aquaculture Science, Gyeongsang National University, Tongyeong 53064, KoreaResearch Center for Industrial Development of Seafood, Gyeongsang National University, Tongyeong 53064, KoreaDepartment of Marine Life Science, Jeju National University, Jeju 63243, KoreaThere is a growing interest in the health benefits of functional foods. A benefit that has been long sought is the control of hypertension through dietary approaches. Hypertension has been implicated as a risk factor for cardiovascular disease and is therefore of clinical significance. Here, we aim to demonstrate the antihypertensive activity of novel peptides derived from surimi, a functional food ingredient made from refined fish myofibrillar proteins. Three peptides, Ile-Val-Asp-Arg (IVDR), Trp-Tyr-Lys (WYK), and Val-Ala-Ser-Val-Ile (VASVI), were isolated from surimi made from the olive flounder (<i>Paralichthys olivaceus</i>). Our results show that IVDR, WYK, and VASVI exhibited high Angiotensin I-converting Enzyme (ACE) inhibition activity. These peptides are also shown to increase phosphorylation of protein kinase B (Akt) and endothelial nitric oxide synthase (eNOS), and significantly promote nitric oxide (NO) production in human umbilical vein endothelial cells. Oral administration of the peptides decreased blood pressure in spontaneously hypertensive rats (SHRs), thereby confirming that the peptides derived from surimi perform antihypertensive activity via the Akt/eNOS pathway. These results indicate that surimi made from <i>P. olivaceus</i> contains novel antihypertensive peptides that could be used to enhance the health benefits of food ingredients.https://www.mdpi.com/2304-8158/9/5/647antihypertensivepeptide<i>Paralichthys olivaceus</i>surimi |
| spellingShingle | Jae-Young Oh Jun-Geon Je Hyo-Geun Lee Eun-A Kim Sang In Kang Jung-Suck Lee You-Jin Jeon Anti-Hypertensive Activity of Novel Peptides Identified from Olive Flounder (<i>Paralichthys olivaceus</i>) Surimi Foods antihypertensive peptide <i>Paralichthys olivaceus</i> surimi |
| title | Anti-Hypertensive Activity of Novel Peptides Identified from Olive Flounder (<i>Paralichthys olivaceus</i>) Surimi |
| title_full | Anti-Hypertensive Activity of Novel Peptides Identified from Olive Flounder (<i>Paralichthys olivaceus</i>) Surimi |
| title_fullStr | Anti-Hypertensive Activity of Novel Peptides Identified from Olive Flounder (<i>Paralichthys olivaceus</i>) Surimi |
| title_full_unstemmed | Anti-Hypertensive Activity of Novel Peptides Identified from Olive Flounder (<i>Paralichthys olivaceus</i>) Surimi |
| title_short | Anti-Hypertensive Activity of Novel Peptides Identified from Olive Flounder (<i>Paralichthys olivaceus</i>) Surimi |
| title_sort | anti hypertensive activity of novel peptides identified from olive flounder i paralichthys olivaceus i surimi |
| topic | antihypertensive peptide <i>Paralichthys olivaceus</i> surimi |
| url | https://www.mdpi.com/2304-8158/9/5/647 |
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