Cytokine quantification and association with cervical length in a prospective cohort of pregnant women
Abstract Background Preterm birth is a leading cause of infant morbidity and mortality; its multifactorial causes are an obstacle to understanding etiology and pathogenesis. The importance of cytokines and inflammation in its etiology and association with the short cervix is nowadays well-proven. To...
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-023-05776-2 |
| _version_ | 1797795477381447680 |
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| author | Helmer Herren Alessandra C. Marcolin Marco A. Barbieri Heloisa Bettiol Viviane C. Cardoso Silvana M. Quintana Ricardo C. Cavalli |
| author_facet | Helmer Herren Alessandra C. Marcolin Marco A. Barbieri Heloisa Bettiol Viviane C. Cardoso Silvana M. Quintana Ricardo C. Cavalli |
| author_sort | Helmer Herren |
| collection | DOAJ |
| description | Abstract Background Preterm birth is a leading cause of infant morbidity and mortality; its multifactorial causes are an obstacle to understanding etiology and pathogenesis. The importance of cytokines and inflammation in its etiology and association with the short cervix is nowadays well-proven. To date, there are no reliable biological or biochemical markers to predict preterm birth; even though the length of the cervix has high specificity, its sensitivity with the cervix below 2.5 cm is low. Objective We study the association of plasma cytokine levels and cervical length in search of predictors of preterm birth. Study design We evaluated a total of 1400 pregnant women carrying a single fetus between 20 and 25 weeks of gestation, and 1370 of them after childbirth in a nested case–control study of a prenatal cohort. Eligible pregnant women were interviewed and submitted to obstetric morphological and transvaginal ultrasound with cervical length measurement, gynecological examination, and blood collection. Preterm birth occurred in 133 women, 129 included in the study, and a control group randomly selected at a 2:1 ratio. A total of 41 cytokines with a higher probability of being associated with preterm birth or being of significance during labor were determined. Results Cytokine and cervical length analysis by multivariate analysis of the conditional interference tree revealed that growth-related oncogene values of less than 2293 pg/mL were significantly associated with a cervical length of less than 2.5 cm. Conclusions As well as a cervical length shorter than 2.5 cm, growth-related oncogene levels of less than 2293 pg/ml may be associated with an increased risk of PB. Analysis based on the association of biomarkers and of the interaction between cytokines is a promising pathway in search of a predictor of preterm birth. |
| first_indexed | 2024-03-13T03:18:33Z |
| format | Article |
| id | doaj.art-ce8135df50514cb4a306be93c88aaa53 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-03-13T03:18:33Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-ce8135df50514cb4a306be93c88aaa532023-06-25T11:31:51ZengBMCBMC Pregnancy and Childbirth1471-23932023-06-012311910.1186/s12884-023-05776-2Cytokine quantification and association with cervical length in a prospective cohort of pregnant womenHelmer Herren0Alessandra C. Marcolin1Marco A. Barbieri2Heloisa Bettiol3Viviane C. Cardoso4Silvana M. Quintana5Ricardo C. Cavalli6Department of Gynecology and Obstetrics, Ribeirão Preto Medical School University of São PauloDepartment of Gynecology and Obstetrics, Ribeirão Preto Medical School University of São PauloDepartment of Puericulture and Pediatrics, Ribeirão Preto Medical School University of São PauloDepartment of Puericulture and Pediatrics, Ribeirão Preto Medical School University of São PauloDepartment of Puericulture and Pediatrics, Ribeirão Preto Medical School University of São PauloDepartment of Gynecology and Obstetrics, Ribeirão Preto Medical School University of São PauloDepartment of Gynecology and Obstetrics, Ribeirão Preto Medical School University of São PauloAbstract Background Preterm birth is a leading cause of infant morbidity and mortality; its multifactorial causes are an obstacle to understanding etiology and pathogenesis. The importance of cytokines and inflammation in its etiology and association with the short cervix is nowadays well-proven. To date, there are no reliable biological or biochemical markers to predict preterm birth; even though the length of the cervix has high specificity, its sensitivity with the cervix below 2.5 cm is low. Objective We study the association of plasma cytokine levels and cervical length in search of predictors of preterm birth. Study design We evaluated a total of 1400 pregnant women carrying a single fetus between 20 and 25 weeks of gestation, and 1370 of them after childbirth in a nested case–control study of a prenatal cohort. Eligible pregnant women were interviewed and submitted to obstetric morphological and transvaginal ultrasound with cervical length measurement, gynecological examination, and blood collection. Preterm birth occurred in 133 women, 129 included in the study, and a control group randomly selected at a 2:1 ratio. A total of 41 cytokines with a higher probability of being associated with preterm birth or being of significance during labor were determined. Results Cytokine and cervical length analysis by multivariate analysis of the conditional interference tree revealed that growth-related oncogene values of less than 2293 pg/mL were significantly associated with a cervical length of less than 2.5 cm. Conclusions As well as a cervical length shorter than 2.5 cm, growth-related oncogene levels of less than 2293 pg/ml may be associated with an increased risk of PB. Analysis based on the association of biomarkers and of the interaction between cytokines is a promising pathway in search of a predictor of preterm birth.https://doi.org/10.1186/s12884-023-05776-2Preterm birthPrematurityChemokinesCervical lengthShort cervixInflammatory markers |
| spellingShingle | Helmer Herren Alessandra C. Marcolin Marco A. Barbieri Heloisa Bettiol Viviane C. Cardoso Silvana M. Quintana Ricardo C. Cavalli Cytokine quantification and association with cervical length in a prospective cohort of pregnant women BMC Pregnancy and Childbirth Preterm birth Prematurity Chemokines Cervical length Short cervix Inflammatory markers |
| title | Cytokine quantification and association with cervical length in a prospective cohort of pregnant women |
| title_full | Cytokine quantification and association with cervical length in a prospective cohort of pregnant women |
| title_fullStr | Cytokine quantification and association with cervical length in a prospective cohort of pregnant women |
| title_full_unstemmed | Cytokine quantification and association with cervical length in a prospective cohort of pregnant women |
| title_short | Cytokine quantification and association with cervical length in a prospective cohort of pregnant women |
| title_sort | cytokine quantification and association with cervical length in a prospective cohort of pregnant women |
| topic | Preterm birth Prematurity Chemokines Cervical length Short cervix Inflammatory markers |
| url | https://doi.org/10.1186/s12884-023-05776-2 |
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