Development of Respiratory Syncytial Virus Vaccine Candidates for the Elderly
Respiratory syncytial virus (RSV) is a significant threat to elderly populations and repeated infections that occur throughout life are poorly protective. To assess the role of prior RSV infections as well as elderly immune senescence on vaccine efficacy, we compared immune responses after virus-lik...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/6/1305 |
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| author | Jorge C. G. Blanco Lori M. Cullen Arash Kamali Fatouomata Y. D. Sylla Marina S. Boukhvalova Trudy G. Morrison |
| author_facet | Jorge C. G. Blanco Lori M. Cullen Arash Kamali Fatouomata Y. D. Sylla Marina S. Boukhvalova Trudy G. Morrison |
| author_sort | Jorge C. G. Blanco |
| collection | DOAJ |
| description | Respiratory syncytial virus (RSV) is a significant threat to elderly populations and repeated infections that occur throughout life are poorly protective. To assess the role of prior RSV infections as well as elderly immune senescence on vaccine efficacy, we compared immune responses after virus-like particle (VLP) immunization of elderly cotton rats and young cotton rats, both previously RSV infected, in order to mimic the human population. We show that immunization of RSV-experienced young or elderly animals resulted in the same levels of anti-pre-F IgG, anti-G IgG, neutralizing antibody titers, and protection from challenge indicating that the delivery of F and G proteins in a VLP is equally effective in activation of protective responses in both elderly and young populations. Our results suggest that F and G protein-containing VLPs induce anti-RSV memory established in prior RSV infections equally well in both young and elderly animals and thus can be an effective vaccine for the elderly. |
| first_indexed | 2024-03-11T01:50:25Z |
| format | Article |
| id | doaj.art-ce843923b5b84c6f969e9a2b6a6b1bd9 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T01:50:25Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-ce843923b5b84c6f969e9a2b6a6b1bd92023-11-18T13:01:54ZengMDPI AGViruses1999-49152023-05-01156130510.3390/v15061305Development of Respiratory Syncytial Virus Vaccine Candidates for the ElderlyJorge C. G. Blanco0Lori M. Cullen1Arash Kamali2Fatouomata Y. D. Sylla3Marina S. Boukhvalova4Trudy G. Morrison5Sigmovir Biosystems Inc., Rockville, MD 20850, USADepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA 01655, USASigmovir Biosystems Inc., Rockville, MD 20850, USASigmovir Biosystems Inc., Rockville, MD 20850, USASigmovir Biosystems Inc., Rockville, MD 20850, USADepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA 01655, USARespiratory syncytial virus (RSV) is a significant threat to elderly populations and repeated infections that occur throughout life are poorly protective. To assess the role of prior RSV infections as well as elderly immune senescence on vaccine efficacy, we compared immune responses after virus-like particle (VLP) immunization of elderly cotton rats and young cotton rats, both previously RSV infected, in order to mimic the human population. We show that immunization of RSV-experienced young or elderly animals resulted in the same levels of anti-pre-F IgG, anti-G IgG, neutralizing antibody titers, and protection from challenge indicating that the delivery of F and G proteins in a VLP is equally effective in activation of protective responses in both elderly and young populations. Our results suggest that F and G protein-containing VLPs induce anti-RSV memory established in prior RSV infections equally well in both young and elderly animals and thus can be an effective vaccine for the elderly.https://www.mdpi.com/1999-4915/15/6/1305respiratory syncytial virusvaccinevirus-like particleimmunity |
| spellingShingle | Jorge C. G. Blanco Lori M. Cullen Arash Kamali Fatouomata Y. D. Sylla Marina S. Boukhvalova Trudy G. Morrison Development of Respiratory Syncytial Virus Vaccine Candidates for the Elderly Viruses respiratory syncytial virus vaccine virus-like particle immunity |
| title | Development of Respiratory Syncytial Virus Vaccine Candidates for the Elderly |
| title_full | Development of Respiratory Syncytial Virus Vaccine Candidates for the Elderly |
| title_fullStr | Development of Respiratory Syncytial Virus Vaccine Candidates for the Elderly |
| title_full_unstemmed | Development of Respiratory Syncytial Virus Vaccine Candidates for the Elderly |
| title_short | Development of Respiratory Syncytial Virus Vaccine Candidates for the Elderly |
| title_sort | development of respiratory syncytial virus vaccine candidates for the elderly |
| topic | respiratory syncytial virus vaccine virus-like particle immunity |
| url | https://www.mdpi.com/1999-4915/15/6/1305 |
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