Polymeric nanoparticles loaded naringin and naringenin: effect of solvent, characterization, photodegradation and stability studies
Naringin (NAR) and naringenin (NGE) are flavonoids with important effects, such as antioxidant, nephroprotective and anti-inflammatory action. However, factors such as poor solubility and oral bioavailability, gastrointestinal instability and extensive first pass metabolism lead to limited delivera...
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| Format: | Article |
| Language: | English |
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Universidade Federal do Rio Grande do Sul
2020-12-01
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| Series: | Drug Analytical Research |
| Online Access: | https://seer.ufrgs.br/index.php/poled/management/settings/website/index.php/dar/article/view/108783 |
| _version_ | 1797318076566339584 |
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| author | Leticia Malgarim Cordenonsi Rafaela Martins Sponchiado Jardel Rodrigo Bandeira Roberto Chris Vianna Santos Renata Platchek Raffin Elfrides Eva Scherman Schapoval |
| author_facet | Leticia Malgarim Cordenonsi Rafaela Martins Sponchiado Jardel Rodrigo Bandeira Roberto Chris Vianna Santos Renata Platchek Raffin Elfrides Eva Scherman Schapoval |
| author_sort | Leticia Malgarim Cordenonsi |
| collection | DOAJ |
| description |
Naringin (NAR) and naringenin (NGE) are flavonoids with important effects, such as antioxidant, nephroprotective and anti-inflammatory action. However, factors such as poor solubility and oral bioavailability, gastrointestinal instability and extensive first pass metabolism lead to limited deliverability. As far as we know, there are no papers describing the use of combination of NAR and NGE in nanoparticles. This paper describes the development and characterization of new nanoparticles containing NAR and NGE (NAR-NGE-NPs) which were prepared by nanoprecipitation using ethanol or mixture of solvents. Size distribution of NAR-NGE-NPs demonstrated a narrow distribution (121 nm), low polydispersity (< 0.1), and encapsulation efficiencies were greater than 80%. Infrared spectroscopy analyses confirmed the structure of NAR-NGE-NPs and in transmission electron microscopy, NAR-NGE-NPs presented a spherical and regular shape. A degradation study by UV-C, NAR-NGE-NPs improved photostability and conferred protection against NAR and NGE degradation. Minimal inhibitory concentrations of NAR and NGE were evaluated, however samples did not show antimicrobial activity. In this investigation, new NAR-NGE-NPs were successfully developed by a nanoprecipitation technique, using Endragit®L100 as polymer and ethanol as solvent.
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| first_indexed | 2024-03-08T03:45:16Z |
| format | Article |
| id | doaj.art-ce870d1ec806468d8a54316db9eab1ef |
| institution | Directory Open Access Journal |
| issn | 2527-2616 |
| language | English |
| last_indexed | 2024-03-08T03:45:16Z |
| publishDate | 2020-12-01 |
| publisher | Universidade Federal do Rio Grande do Sul |
| record_format | Article |
| series | Drug Analytical Research |
| spelling | doaj.art-ce870d1ec806468d8a54316db9eab1ef2024-02-09T18:14:35ZengUniversidade Federal do Rio Grande do SulDrug Analytical Research2527-26162020-12-0142Polymeric nanoparticles loaded naringin and naringenin: effect of solvent, characterization, photodegradation and stability studiesLeticia Malgarim Cordenonsi0Rafaela Martins Sponchiado1Jardel Rodrigo Bandeira2Roberto Chris Vianna Santos3Renata Platchek Raffin4Elfrides Eva Scherman Schapoval5Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do SulPrograma de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do SulPrograma de Pós-Graduação em Nanociências Universidade FranciscanaMicrobiology and Parasitology Department Federal University of Santa MariPrograma de Pós-Graduação em Nanociências Universidade FranciscanaPrograma de Pós-Graduação em Ciências Farmacêuticas Faculdade de Farmácia Universidade Federal do Rio Grande do Sul Naringin (NAR) and naringenin (NGE) are flavonoids with important effects, such as antioxidant, nephroprotective and anti-inflammatory action. However, factors such as poor solubility and oral bioavailability, gastrointestinal instability and extensive first pass metabolism lead to limited deliverability. As far as we know, there are no papers describing the use of combination of NAR and NGE in nanoparticles. This paper describes the development and characterization of new nanoparticles containing NAR and NGE (NAR-NGE-NPs) which were prepared by nanoprecipitation using ethanol or mixture of solvents. Size distribution of NAR-NGE-NPs demonstrated a narrow distribution (121 nm), low polydispersity (< 0.1), and encapsulation efficiencies were greater than 80%. Infrared spectroscopy analyses confirmed the structure of NAR-NGE-NPs and in transmission electron microscopy, NAR-NGE-NPs presented a spherical and regular shape. A degradation study by UV-C, NAR-NGE-NPs improved photostability and conferred protection against NAR and NGE degradation. Minimal inhibitory concentrations of NAR and NGE were evaluated, however samples did not show antimicrobial activity. In this investigation, new NAR-NGE-NPs were successfully developed by a nanoprecipitation technique, using Endragit®L100 as polymer and ethanol as solvent. https://seer.ufrgs.br/index.php/poled/management/settings/website/index.php/dar/article/view/108783 |
| spellingShingle | Leticia Malgarim Cordenonsi Rafaela Martins Sponchiado Jardel Rodrigo Bandeira Roberto Chris Vianna Santos Renata Platchek Raffin Elfrides Eva Scherman Schapoval Polymeric nanoparticles loaded naringin and naringenin: effect of solvent, characterization, photodegradation and stability studies Drug Analytical Research |
| title | Polymeric nanoparticles loaded naringin and naringenin: effect of solvent, characterization, photodegradation and stability studies |
| title_full | Polymeric nanoparticles loaded naringin and naringenin: effect of solvent, characterization, photodegradation and stability studies |
| title_fullStr | Polymeric nanoparticles loaded naringin and naringenin: effect of solvent, characterization, photodegradation and stability studies |
| title_full_unstemmed | Polymeric nanoparticles loaded naringin and naringenin: effect of solvent, characterization, photodegradation and stability studies |
| title_short | Polymeric nanoparticles loaded naringin and naringenin: effect of solvent, characterization, photodegradation and stability studies |
| title_sort | polymeric nanoparticles loaded naringin and naringenin effect of solvent characterization photodegradation and stability studies |
| url | https://seer.ufrgs.br/index.php/poled/management/settings/website/index.php/dar/article/view/108783 |
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