Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer
The biosynthetic transport route that constitutes the secretory pathway plays a fundamental role in the cell, providing to the synthesis and transport of around one third of human proteins and most lipids. Signaling molecules within autoregulatory circuits on the intracellular membranes of the secre...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.833663/full |
| _version_ | 1819173768439791616 |
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| author | Simona Del Giudice Valentina De Luca Seyedehnegar Parizadeh Domenico Russo Alberto Luini Rosaria Di Martino |
| author_facet | Simona Del Giudice Valentina De Luca Seyedehnegar Parizadeh Domenico Russo Alberto Luini Rosaria Di Martino |
| author_sort | Simona Del Giudice |
| collection | DOAJ |
| description | The biosynthetic transport route that constitutes the secretory pathway plays a fundamental role in the cell, providing to the synthesis and transport of around one third of human proteins and most lipids. Signaling molecules within autoregulatory circuits on the intracellular membranes of the secretory pathway regulate these processes, especially at the level of the Golgi complex. Indeed, cancer cells can hijack several of these signaling molecules, and therefore also the underlying regulated processes, to bolster their growth or gain more aggressive phenotypes. Here, we review the most important autoregulatory circuits acting on the Golgi, emphasizing the role of specific signaling molecules in cancer. In fact, we propose to draw awareness to highlight the Golgi-localized regulatory systems as potential targets in cancer therapy. |
| first_indexed | 2024-12-22T20:28:20Z |
| format | Article |
| id | doaj.art-ce87a23df4c148aa87ff40768e67a91b |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-22T20:28:20Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-ce87a23df4c148aa87ff40768e67a91b2022-12-21T18:13:41ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-03-011010.3389/fcell.2022.833663833663Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in CancerSimona Del GiudiceValentina De LucaSeyedehnegar ParizadehDomenico RussoAlberto LuiniRosaria Di MartinoThe biosynthetic transport route that constitutes the secretory pathway plays a fundamental role in the cell, providing to the synthesis and transport of around one third of human proteins and most lipids. Signaling molecules within autoregulatory circuits on the intracellular membranes of the secretory pathway regulate these processes, especially at the level of the Golgi complex. Indeed, cancer cells can hijack several of these signaling molecules, and therefore also the underlying regulated processes, to bolster their growth or gain more aggressive phenotypes. Here, we review the most important autoregulatory circuits acting on the Golgi, emphasizing the role of specific signaling molecules in cancer. In fact, we propose to draw awareness to highlight the Golgi-localized regulatory systems as potential targets in cancer therapy.https://www.frontiersin.org/articles/10.3389/fcell.2022.833663/fullGolgisecretory pathwaysecretionprotein transportcancercontrol system |
| spellingShingle | Simona Del Giudice Valentina De Luca Seyedehnegar Parizadeh Domenico Russo Alberto Luini Rosaria Di Martino Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer Frontiers in Cell and Developmental Biology Golgi secretory pathway secretion protein transport cancer control system |
| title | Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer |
| title_full | Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer |
| title_fullStr | Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer |
| title_full_unstemmed | Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer |
| title_short | Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer |
| title_sort | endogenous and exogenous regulatory signaling in the secretory pathway role of golgi signaling molecules in cancer |
| topic | Golgi secretory pathway secretion protein transport cancer control system |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.833663/full |
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