Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery.
Traditional and non-traditional risk factors for atherosclerotic cardiovascular disease (ASCVD) are different between men and women. Gender-linked impact of epicardial adipose tissue volume (EATV) in patients undergoing coronary artery bypass grafting (CABG) remains unknown.Gender-linked impact of E...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5464529?pdf=render |
| _version_ | 1828371363969105920 |
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| author | Gulinu Maimaituxun Michio Shimabukuro Hotimah Masdan Salim Minoru Tabata Daisuke Yuji Yoshihisa Morimoto Takeshi Akasaka Tomomi Matsuura Shusuke Yagi Daiju Fukuda Hirotsugu Yamada Takeshi Soeki Takaki Sugimoto Masashi Tanaka Shuichiro Takanashi Masataka Sata |
| author_facet | Gulinu Maimaituxun Michio Shimabukuro Hotimah Masdan Salim Minoru Tabata Daisuke Yuji Yoshihisa Morimoto Takeshi Akasaka Tomomi Matsuura Shusuke Yagi Daiju Fukuda Hirotsugu Yamada Takeshi Soeki Takaki Sugimoto Masashi Tanaka Shuichiro Takanashi Masataka Sata |
| author_sort | Gulinu Maimaituxun |
| collection | DOAJ |
| description | Traditional and non-traditional risk factors for atherosclerotic cardiovascular disease (ASCVD) are different between men and women. Gender-linked impact of epicardial adipose tissue volume (EATV) in patients undergoing coronary artery bypass grafting (CABG) remains unknown.Gender-linked impact of EATV, abdominal fat distribution and other traditional ASCVD risk factors were compared in 172 patients (men: 115; women: 57) who underwent CABG or non-coronary valvular surgery (non-CABG).In men, EATV, EATV index (EATV/body surface area) and the markers of adiposity such as body mass index, waist circumference and visceral fat area were higher in the CABG group than in the non-CABG group. Traditional ASCVD risk factors were also prevalent in the CABG group. In women, EATV and EATV index were higher in the CABG group, but other adiposity markers were comparable between CABG and non-CABG groups. Multivariate logistic regression analysis showed that in men, CABG was determined by EATV Index and other ASCVD risk factors including hypertension, dyslipidemia, adiponectin, high sensitive C-reactive protein (hsCRP) and type 2 diabetes mellitus (Corrected R2 = 0.262, p < 0.0001), while in women, type 2 diabetes mellitus is a single strong predictor for CABG, excluding EATV Index (Corrected R2 = 0.266, p = 0.005).Our study found that multiple risk factors, including epicardial adipose tissue volume and traditional ASCVD factors are determinants for CABG in men, but type 2 diabetes mellitus was the sole determinant in women. Gender-specific disparities in risk factors of CABG prompt us to evaluate new diagnostic and treatment strategies and to seek underlying mechanisms. |
| first_indexed | 2024-04-14T06:48:55Z |
| format | Article |
| id | doaj.art-ce88f39a9eac4870ab766a08fdcd1e4a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T06:48:55Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ce88f39a9eac4870ab766a08fdcd1e4a2022-12-22T02:07:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e017717010.1371/journal.pone.0177170Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery.Gulinu MaimaituxunMichio ShimabukuroHotimah Masdan SalimMinoru TabataDaisuke YujiYoshihisa MorimotoTakeshi AkasakaTomomi MatsuuraShusuke YagiDaiju FukudaHirotsugu YamadaTakeshi SoekiTakaki SugimotoMasashi TanakaShuichiro TakanashiMasataka SataTraditional and non-traditional risk factors for atherosclerotic cardiovascular disease (ASCVD) are different between men and women. Gender-linked impact of epicardial adipose tissue volume (EATV) in patients undergoing coronary artery bypass grafting (CABG) remains unknown.Gender-linked impact of EATV, abdominal fat distribution and other traditional ASCVD risk factors were compared in 172 patients (men: 115; women: 57) who underwent CABG or non-coronary valvular surgery (non-CABG).In men, EATV, EATV index (EATV/body surface area) and the markers of adiposity such as body mass index, waist circumference and visceral fat area were higher in the CABG group than in the non-CABG group. Traditional ASCVD risk factors were also prevalent in the CABG group. In women, EATV and EATV index were higher in the CABG group, but other adiposity markers were comparable between CABG and non-CABG groups. Multivariate logistic regression analysis showed that in men, CABG was determined by EATV Index and other ASCVD risk factors including hypertension, dyslipidemia, adiponectin, high sensitive C-reactive protein (hsCRP) and type 2 diabetes mellitus (Corrected R2 = 0.262, p < 0.0001), while in women, type 2 diabetes mellitus is a single strong predictor for CABG, excluding EATV Index (Corrected R2 = 0.266, p = 0.005).Our study found that multiple risk factors, including epicardial adipose tissue volume and traditional ASCVD factors are determinants for CABG in men, but type 2 diabetes mellitus was the sole determinant in women. Gender-specific disparities in risk factors of CABG prompt us to evaluate new diagnostic and treatment strategies and to seek underlying mechanisms.http://europepmc.org/articles/PMC5464529?pdf=render |
| spellingShingle | Gulinu Maimaituxun Michio Shimabukuro Hotimah Masdan Salim Minoru Tabata Daisuke Yuji Yoshihisa Morimoto Takeshi Akasaka Tomomi Matsuura Shusuke Yagi Daiju Fukuda Hirotsugu Yamada Takeshi Soeki Takaki Sugimoto Masashi Tanaka Shuichiro Takanashi Masataka Sata Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery. PLoS ONE |
| title | Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery. |
| title_full | Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery. |
| title_fullStr | Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery. |
| title_full_unstemmed | Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery. |
| title_short | Gender-linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non-coronary valve surgery. |
| title_sort | gender linked impact of epicardial adipose tissue volume in patients who underwent coronary artery bypass graft surgery or non coronary valve surgery |
| url | http://europepmc.org/articles/PMC5464529?pdf=render |
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