Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells
Imaging non-repetitive loci in living cells remains challenging. Here, the authors engineered an inducible system whereby biomolecular assemblies can be guided to specific genomic loci by a nuclease-defective Cas9, allowing the simultaneous imaging and manipulation of the loci.
Bibliographic Details
| Main Authors: |
Qin Peng,
Ziliang Huang,
Kun Sun,
Yahan Liu,
Chi Woo Yoon,
Reed E. S. Harrison,
Danielle L. Schmitt,
Linshan Zhu,
Yiqian Wu,
Ipek Tasan,
Huimin Zhao,
Jin Zhang,
Sheng Zhong,
Shu Chien,
Yingxiao Wang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-35504-x
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