Oral administration of tannins and flavonoids in children with acute diarrhea: a pilot, randomized, control-case study
Abstract Background AG is the most common cause of pediatric consultations among children between 2 and 5 years of age and it still leads to high mortality and morbidity. Its management is based on rehydration therapy, but this treatment is not effective in reducing duration of diarrhea. For this re...
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | Italian Journal of Pediatrics |
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| Online Access: | http://link.springer.com/article/10.1186/s13052-018-0497-6 |
| _version_ | 1818288552047280128 |
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| author | Marina Russo Vincenzo Coppola Eleonora Giannetti Roberta Buonavolontà Antonio Piscitelli Annamaria Staiano |
| author_facet | Marina Russo Vincenzo Coppola Eleonora Giannetti Roberta Buonavolontà Antonio Piscitelli Annamaria Staiano |
| author_sort | Marina Russo |
| collection | DOAJ |
| description | Abstract Background AG is the most common cause of pediatric consultations among children between 2 and 5 years of age and it still leads to high mortality and morbidity. Its management is based on rehydration therapy, but this treatment is not effective in reducing duration of diarrhea. For this reason, other safer and less expensive interventions, which could be added to oral rehydration therapy, are of great interest. Methods A pilot, randomized, case-controlled trial was conducted in 60 children affected by AG (< 7 days) with mild-moderate dehydration, according to WHO recommendations, from1 year to 17 years old. Patients were divided into 2 Groups: Group 1 consisting of 30 children treated with Actitan F and standard oral rehydration (SOR); Group 2 consisting of 30 children who received only SOR. Both groups received treatment for seven days, respectively. Patients of Group 1 stopped for their own choice, SOR after the first 24 h and continued only with Actitan F. Results After 24 h of treatment, the median number of stools was 3.5 for Group 1, and 4 for Group 2. In Group 1 the difference between the number of stools at baseline (n = 5) and after 24 h of treatment (n = 3.5) was significant (p < 0.0001). At the end of treatment, the median duration of diarrhea in Group 1 was 5 days, compared with 4 days in the Group 2, this difference was not statically significant (p 0.48). Conclusions Oral administration of Actitan F associated with SOR seems safe and effective treatment in shortening the duration of AG in children. Further studies confirming these data are needed. Trial registration NCT03356327 (retrospectively registered). |
| first_indexed | 2024-12-13T01:58:11Z |
| format | Article |
| id | doaj.art-ce8c5c9e891941f99c17429c58498cf7 |
| institution | Directory Open Access Journal |
| issn | 1824-7288 |
| language | English |
| last_indexed | 2024-12-13T01:58:11Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-ce8c5c9e891941f99c17429c58498cf72022-12-22T00:03:20ZengBMCItalian Journal of Pediatrics1824-72882018-06-014411610.1186/s13052-018-0497-6Oral administration of tannins and flavonoids in children with acute diarrhea: a pilot, randomized, control-case studyMarina Russo0Vincenzo Coppola1Eleonora Giannetti2Roberta Buonavolontà3Antonio Piscitelli4Annamaria Staiano5Department of Translational Medical Science, Section of Pediatrics, “Federico II” University of NaplesDepartment of Translational Medical Science, Section of Pediatrics, “Federico II” University of NaplesDepartment of Translational Medical Science, Section of Pediatrics, “Federico II” University of NaplesDepartment of Translational Medical Science, Section of Pediatrics, “Federico II” University of NaplesDepartment of Translational Medical Science, Section of Pediatrics, “Federico II” University of NaplesDepartment of Translational Medical Science, Section of Pediatrics, “Federico II” University of NaplesAbstract Background AG is the most common cause of pediatric consultations among children between 2 and 5 years of age and it still leads to high mortality and morbidity. Its management is based on rehydration therapy, but this treatment is not effective in reducing duration of diarrhea. For this reason, other safer and less expensive interventions, which could be added to oral rehydration therapy, are of great interest. Methods A pilot, randomized, case-controlled trial was conducted in 60 children affected by AG (< 7 days) with mild-moderate dehydration, according to WHO recommendations, from1 year to 17 years old. Patients were divided into 2 Groups: Group 1 consisting of 30 children treated with Actitan F and standard oral rehydration (SOR); Group 2 consisting of 30 children who received only SOR. Both groups received treatment for seven days, respectively. Patients of Group 1 stopped for their own choice, SOR after the first 24 h and continued only with Actitan F. Results After 24 h of treatment, the median number of stools was 3.5 for Group 1, and 4 for Group 2. In Group 1 the difference between the number of stools at baseline (n = 5) and after 24 h of treatment (n = 3.5) was significant (p < 0.0001). At the end of treatment, the median duration of diarrhea in Group 1 was 5 days, compared with 4 days in the Group 2, this difference was not statically significant (p 0.48). Conclusions Oral administration of Actitan F associated with SOR seems safe and effective treatment in shortening the duration of AG in children. Further studies confirming these data are needed. Trial registration NCT03356327 (retrospectively registered).http://link.springer.com/article/10.1186/s13052-018-0497-6Acute gastroenteritisTreatmentTanninsFlavonoids |
| spellingShingle | Marina Russo Vincenzo Coppola Eleonora Giannetti Roberta Buonavolontà Antonio Piscitelli Annamaria Staiano Oral administration of tannins and flavonoids in children with acute diarrhea: a pilot, randomized, control-case study Italian Journal of Pediatrics Acute gastroenteritis Treatment Tannins Flavonoids |
| title | Oral administration of tannins and flavonoids in children with acute diarrhea: a pilot, randomized, control-case study |
| title_full | Oral administration of tannins and flavonoids in children with acute diarrhea: a pilot, randomized, control-case study |
| title_fullStr | Oral administration of tannins and flavonoids in children with acute diarrhea: a pilot, randomized, control-case study |
| title_full_unstemmed | Oral administration of tannins and flavonoids in children with acute diarrhea: a pilot, randomized, control-case study |
| title_short | Oral administration of tannins and flavonoids in children with acute diarrhea: a pilot, randomized, control-case study |
| title_sort | oral administration of tannins and flavonoids in children with acute diarrhea a pilot randomized control case study |
| topic | Acute gastroenteritis Treatment Tannins Flavonoids |
| url | http://link.springer.com/article/10.1186/s13052-018-0497-6 |
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