Antiglomerular Basement Membrane Disease Possibly Triggered by Undiagnosed Renal Cell Carcinoma: A Case Report
Antiglomerular basement membrane (anti-GBM) disease is a rare, small-vessel vasculitis that affects the capillary beds of the kidneys and lungs. Although exceedingly rare, several case reports have described anti-GBM disease with a concurrent cancer diagnosis, suggesting a possible correlation betwe...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Kidney Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590059523001279 |
| _version_ | 1797692828499836928 |
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| author | Mariell Rivedal Yngvar Lunde Haaskjold Hedda Berge Thomas Knoop |
| author_facet | Mariell Rivedal Yngvar Lunde Haaskjold Hedda Berge Thomas Knoop |
| author_sort | Mariell Rivedal |
| collection | DOAJ |
| description | Antiglomerular basement membrane (anti-GBM) disease is a rare, small-vessel vasculitis that affects the capillary beds of the kidneys and lungs. Although exceedingly rare, several case reports have described anti-GBM disease with a concurrent cancer diagnosis, suggesting a possible correlation between these 2 conditions. Herein, we describe the first known case to our knowledge of a woman in her early 60s with simultaneous anti-GBM disease and clear cell renal cell carcinoma, in which the tumor was thought to have been the substrate for anti-GBM disease. We believe that renal cell carcinoma may have contributed to the production of anti-GBM autoantibodies and, thus, anti-GBM disease. The concurrence of these 2 conditions complicated the treatment of the patient, who was hemodialysis-dependent at the time of hospital discharge. This report highlights the importance of considering anti-GBM disease as a potential diagnosis in patients with acute kidney failure, and how important it is to identify both clear cell renal cell carcinoma and anti-GBM disease at an early stage to improve outcomes. |
| first_indexed | 2024-03-12T02:33:11Z |
| format | Article |
| id | doaj.art-ce8ce670c78240f99425be0e8e97e2ed |
| institution | Directory Open Access Journal |
| issn | 2590-0595 |
| language | English |
| last_indexed | 2024-03-12T02:33:11Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney Medicine |
| spelling | doaj.art-ce8ce670c78240f99425be0e8e97e2ed2023-09-05T04:16:12ZengElsevierKidney Medicine2590-05952023-10-01510100709Antiglomerular Basement Membrane Disease Possibly Triggered by Undiagnosed Renal Cell Carcinoma: A Case ReportMariell Rivedal0Yngvar Lunde Haaskjold1Hedda Berge2Thomas Knoop3Department of Clinical Medicine, University of Bergen, Bergen, NorwayDepartment of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, NorwayDepartment of Medicine, Haukeland University Hospital, Bergen, NorwayDepartment of Clinical Medicine, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway; Address for Correspondence: Thomas Knoop, PhD, Haukeland University Hospital, University of Bergen, Postbox 7804, 5020 Bergen, Norway.Antiglomerular basement membrane (anti-GBM) disease is a rare, small-vessel vasculitis that affects the capillary beds of the kidneys and lungs. Although exceedingly rare, several case reports have described anti-GBM disease with a concurrent cancer diagnosis, suggesting a possible correlation between these 2 conditions. Herein, we describe the first known case to our knowledge of a woman in her early 60s with simultaneous anti-GBM disease and clear cell renal cell carcinoma, in which the tumor was thought to have been the substrate for anti-GBM disease. We believe that renal cell carcinoma may have contributed to the production of anti-GBM autoantibodies and, thus, anti-GBM disease. The concurrence of these 2 conditions complicated the treatment of the patient, who was hemodialysis-dependent at the time of hospital discharge. This report highlights the importance of considering anti-GBM disease as a potential diagnosis in patients with acute kidney failure, and how important it is to identify both clear cell renal cell carcinoma and anti-GBM disease at an early stage to improve outcomes.http://www.sciencedirect.com/science/article/pii/S2590059523001279Antiglomerular basement membrane diseaserenal cell carcinomaplasmapheresisimmunosuppressionacute kidney injuryrapidly progressive glomerulonephritis |
| spellingShingle | Mariell Rivedal Yngvar Lunde Haaskjold Hedda Berge Thomas Knoop Antiglomerular Basement Membrane Disease Possibly Triggered by Undiagnosed Renal Cell Carcinoma: A Case Report Kidney Medicine Antiglomerular basement membrane disease renal cell carcinoma plasmapheresis immunosuppression acute kidney injury rapidly progressive glomerulonephritis |
| title | Antiglomerular Basement Membrane Disease Possibly Triggered by Undiagnosed Renal Cell Carcinoma: A Case Report |
| title_full | Antiglomerular Basement Membrane Disease Possibly Triggered by Undiagnosed Renal Cell Carcinoma: A Case Report |
| title_fullStr | Antiglomerular Basement Membrane Disease Possibly Triggered by Undiagnosed Renal Cell Carcinoma: A Case Report |
| title_full_unstemmed | Antiglomerular Basement Membrane Disease Possibly Triggered by Undiagnosed Renal Cell Carcinoma: A Case Report |
| title_short | Antiglomerular Basement Membrane Disease Possibly Triggered by Undiagnosed Renal Cell Carcinoma: A Case Report |
| title_sort | antiglomerular basement membrane disease possibly triggered by undiagnosed renal cell carcinoma a case report |
| topic | Antiglomerular basement membrane disease renal cell carcinoma plasmapheresis immunosuppression acute kidney injury rapidly progressive glomerulonephritis |
| url | http://www.sciencedirect.com/science/article/pii/S2590059523001279 |
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