Rapid exacerbation of multiple sclerosis following the initiation of interferon-β: report of nine cases
Background: Interferon-β (IFN-β) is an effective drug in multiple sclerosis (MS) but it may cause acute exacerbation of MS following the initiation of treatment. This study evaluated patients with rapid exacerbation of multiple sclerosis (REMS) following the initiation of IFN-β. Methods: We retrospe...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Journal of Research in Medical Sciences |
| Subjects: | |
| Online Access: | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2011;volume=16;issue=12;spage=1619;epage=1622;aulast=Etemadifar |
| _version_ | 1818132108926779392 |
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| author | Masoud Etemadifar Amir Hossein Sarrami |
| author_facet | Masoud Etemadifar Amir Hossein Sarrami |
| author_sort | Masoud Etemadifar |
| collection | DOAJ |
| description | Background: Interferon-β (IFN-β) is an effective drug in multiple sclerosis (MS) but it may cause acute exacerbation of MS following the initiation of treatment. This study evaluated patients with rapid exacerbation of multiple sclerosis (REMS) following the initiation of IFN-β.
Methods: We retrospectively reviewed the clinical records of 2350 patients with multiple sclerosis who started treatment with IFN-β and were registered with Isfahan MS Society (IMSS). Patients with rapid exacerbation of multiple sclerosis within 24 hours after initiation of IFN-β treatment were selected and their demographic and clinical data were extracted.
Results: We identified nine patients with rapid exacerbation of multiple sclerosis following the initiation of IFN-β. Their mean age at the time of treatment with IFN-β was 37.3 ± 6.28 years. Seven patients had rapid exacerbation of multiple sclerosis after initiation of IFN-β 1a and two patients after IFN-β 1b. The course of disease in all of these patients was relapsing-remitting. However, all had converted into secondary progression within the first year after occurrence of rapid exacerbation of multiple sclerosis following the initiation of IFN-β.
Conclusions: This study may indicate that the effects of IFN-β are not purely anti-inflammatory and a small percentage of MS patients experience rapid exacerbation of multiple sclerosis following the initiation of IFN-β. Future studies are needed to validate our findings. |
| first_indexed | 2024-12-11T08:31:36Z |
| format | Article |
| id | doaj.art-ce8d8330071c448b92532696e869063d |
| institution | Directory Open Access Journal |
| issn | 1735-1995 1735-7136 |
| language | English |
| last_indexed | 2024-12-11T08:31:36Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Research in Medical Sciences |
| spelling | doaj.art-ce8d8330071c448b92532696e869063d2022-12-22T01:14:26ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362011-01-01161216191622Rapid exacerbation of multiple sclerosis following the initiation of interferon-β: report of nine casesMasoud EtemadifarAmir Hossein SarramiBackground: Interferon-β (IFN-β) is an effective drug in multiple sclerosis (MS) but it may cause acute exacerbation of MS following the initiation of treatment. This study evaluated patients with rapid exacerbation of multiple sclerosis (REMS) following the initiation of IFN-β. Methods: We retrospectively reviewed the clinical records of 2350 patients with multiple sclerosis who started treatment with IFN-β and were registered with Isfahan MS Society (IMSS). Patients with rapid exacerbation of multiple sclerosis within 24 hours after initiation of IFN-β treatment were selected and their demographic and clinical data were extracted. Results: We identified nine patients with rapid exacerbation of multiple sclerosis following the initiation of IFN-β. Their mean age at the time of treatment with IFN-β was 37.3 ± 6.28 years. Seven patients had rapid exacerbation of multiple sclerosis after initiation of IFN-β 1a and two patients after IFN-β 1b. The course of disease in all of these patients was relapsing-remitting. However, all had converted into secondary progression within the first year after occurrence of rapid exacerbation of multiple sclerosis following the initiation of IFN-β. Conclusions: This study may indicate that the effects of IFN-β are not purely anti-inflammatory and a small percentage of MS patients experience rapid exacerbation of multiple sclerosis following the initiation of IFN-β. Future studies are needed to validate our findings.http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2011;volume=16;issue=12;spage=1619;epage=1622;aulast=EtemadifarMultiple SclerosisInterferon-βRapid ExacerbationCentral Nervous System |
| spellingShingle | Masoud Etemadifar Amir Hossein Sarrami Rapid exacerbation of multiple sclerosis following the initiation of interferon-β: report of nine cases Journal of Research in Medical Sciences Multiple Sclerosis Interferon-β Rapid Exacerbation Central Nervous System |
| title | Rapid exacerbation of multiple sclerosis following the initiation of interferon-β: report of nine cases |
| title_full | Rapid exacerbation of multiple sclerosis following the initiation of interferon-β: report of nine cases |
| title_fullStr | Rapid exacerbation of multiple sclerosis following the initiation of interferon-β: report of nine cases |
| title_full_unstemmed | Rapid exacerbation of multiple sclerosis following the initiation of interferon-β: report of nine cases |
| title_short | Rapid exacerbation of multiple sclerosis following the initiation of interferon-β: report of nine cases |
| title_sort | rapid exacerbation of multiple sclerosis following the initiation of interferon β report of nine cases |
| topic | Multiple Sclerosis Interferon-β Rapid Exacerbation Central Nervous System |
| url | http://www.jmsjournal.net/article.asp?issn=1735-1995;year=2011;volume=16;issue=12;spage=1619;epage=1622;aulast=Etemadifar |
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