Epigenetic and Genetic Keys to Fight HPV-Related Cancers
Cervical cancer ranks as the fourth most prevalent cancer among women globally, with approximately 600,000 new cases being diagnosed each year. The principal driver of cervical cancer is the human papillomavirus (HPV), where viral oncoproteins E6 and E7 undertake the role of driving its carcinogenic...
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MDPI AG
2023-11-01
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Series: | Cancers |
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Online Access: | https://www.mdpi.com/2072-6694/15/23/5583 |
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author | Veronica Folliero Federica Dell’Annunziata Annalisa Chianese Maria Vittoria Morone Francesca Mensitieri Federica Di Spirito Antonio Mollo Massimo Amato Massimiliano Galdiero Fabrizio Dal Piaz Pasquale Pagliano Luca Rinaldi Gianluigi Franci |
author_facet | Veronica Folliero Federica Dell’Annunziata Annalisa Chianese Maria Vittoria Morone Francesca Mensitieri Federica Di Spirito Antonio Mollo Massimo Amato Massimiliano Galdiero Fabrizio Dal Piaz Pasquale Pagliano Luca Rinaldi Gianluigi Franci |
author_sort | Veronica Folliero |
collection | DOAJ |
description | Cervical cancer ranks as the fourth most prevalent cancer among women globally, with approximately 600,000 new cases being diagnosed each year. The principal driver of cervical cancer is the human papillomavirus (HPV), where viral oncoproteins E6 and E7 undertake the role of driving its carcinogenic potential. Despite extensive investigative efforts, numerous facets concerning HPV infection, replication, and pathogenesis remain shrouded in uncertainty. The virus operates through a variety of epigenetic mechanisms, and the epigenetic signature of HPV-related tumors is a major bottleneck in our understanding of the disease. Recent investigations have unveiled the capacity of viral oncoproteins to influence epigenetic changes within HPV-related tumors, and conversely, these tumors exert an influence on the surrounding epigenetic landscape. Given the escalating occurrence of HPV-triggered tumors and the deficiency of efficacious treatments, substantial challenges emerge. A promising avenue to address this challenge lies in epigenetic modulators. This review aggregates and dissects potential epigenetic modulators capable of combatting HPV-associated infections and diseases. By delving into these modulators, novel avenues for therapeutic interventions against HPV-linked cancers have come to the fore. |
first_indexed | 2024-03-09T01:54:14Z |
format | Article |
id | doaj.art-ce8dda1334d34913969495f35989776c |
institution | Directory Open Access Journal |
issn | 2072-6694 |
language | English |
last_indexed | 2024-03-09T01:54:14Z |
publishDate | 2023-11-01 |
publisher | MDPI AG |
record_format | Article |
series | Cancers |
spelling | doaj.art-ce8dda1334d34913969495f35989776c2023-12-08T15:12:37ZengMDPI AGCancers2072-66942023-11-011523558310.3390/cancers15235583Epigenetic and Genetic Keys to Fight HPV-Related CancersVeronica Folliero0Federica Dell’Annunziata1Annalisa Chianese2Maria Vittoria Morone3Francesca Mensitieri4Federica Di Spirito5Antonio Mollo6Massimo Amato7Massimiliano Galdiero8Fabrizio Dal Piaz9Pasquale Pagliano10Luca Rinaldi11Gianluigi Franci12Department of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyDepartment of Medicine and Health Sciences “Vincenzo Tiberio”, Università degli Studi del Molise, 86100 Campobasso, ItalyDepartment of Medicine, Surgery and Dentistry “Scuola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyCervical cancer ranks as the fourth most prevalent cancer among women globally, with approximately 600,000 new cases being diagnosed each year. The principal driver of cervical cancer is the human papillomavirus (HPV), where viral oncoproteins E6 and E7 undertake the role of driving its carcinogenic potential. Despite extensive investigative efforts, numerous facets concerning HPV infection, replication, and pathogenesis remain shrouded in uncertainty. The virus operates through a variety of epigenetic mechanisms, and the epigenetic signature of HPV-related tumors is a major bottleneck in our understanding of the disease. Recent investigations have unveiled the capacity of viral oncoproteins to influence epigenetic changes within HPV-related tumors, and conversely, these tumors exert an influence on the surrounding epigenetic landscape. Given the escalating occurrence of HPV-triggered tumors and the deficiency of efficacious treatments, substantial challenges emerge. A promising avenue to address this challenge lies in epigenetic modulators. This review aggregates and dissects potential epigenetic modulators capable of combatting HPV-associated infections and diseases. By delving into these modulators, novel avenues for therapeutic interventions against HPV-linked cancers have come to the fore.https://www.mdpi.com/2072-6694/15/23/5583human papillomavirusepigenetic regulationcancercombinatorial therapies |
spellingShingle | Veronica Folliero Federica Dell’Annunziata Annalisa Chianese Maria Vittoria Morone Francesca Mensitieri Federica Di Spirito Antonio Mollo Massimo Amato Massimiliano Galdiero Fabrizio Dal Piaz Pasquale Pagliano Luca Rinaldi Gianluigi Franci Epigenetic and Genetic Keys to Fight HPV-Related Cancers Cancers human papillomavirus epigenetic regulation cancer combinatorial therapies |
title | Epigenetic and Genetic Keys to Fight HPV-Related Cancers |
title_full | Epigenetic and Genetic Keys to Fight HPV-Related Cancers |
title_fullStr | Epigenetic and Genetic Keys to Fight HPV-Related Cancers |
title_full_unstemmed | Epigenetic and Genetic Keys to Fight HPV-Related Cancers |
title_short | Epigenetic and Genetic Keys to Fight HPV-Related Cancers |
title_sort | epigenetic and genetic keys to fight hpv related cancers |
topic | human papillomavirus epigenetic regulation cancer combinatorial therapies |
url | https://www.mdpi.com/2072-6694/15/23/5583 |
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