Supratentorial Collision Tumor of Hemangioblastoma and Metastatic Clear Cell Renal Cell Carcinoma in a Patient with von Hippel-Lindau Disease
Collision tumors are rarely reported in patients with von Hippel-Lindau (VHL) disease, even though VHL patients often present with multi-organ tumor syndromes, like hemangioblastoma and renal cell carcinoma (RCC). Hemangioblastoma is rarely located in a supratentorial location, and intracranial late...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2023-09-01
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| Series: | Case Reports in Oncology |
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| Online Access: | https://beta.karger.com/Article/FullText/531876 |
| _version_ | 1797660946545508352 |
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| author | Wenjun Luo Cuiyun Sun Shizhu Yu |
| author_facet | Wenjun Luo Cuiyun Sun Shizhu Yu |
| author_sort | Wenjun Luo |
| collection | DOAJ |
| description | Collision tumors are rarely reported in patients with von Hippel-Lindau (VHL) disease, even though VHL patients often present with multi-organ tumor syndromes, like hemangioblastoma and renal cell carcinoma (RCC). Hemangioblastoma is rarely located in a supratentorial location, and intracranial lateral ventricular is also not a common site of metastasis for RCC. It is extremely rare for the two tumors to collide in the supratentorial area. We report a 64-year-old man with a history of clear cell RCC who presented with a sudden headache. The brain magnetic resonance imaging revealed that there was a cystic-solid mass in the intracranial lateral ventricular trigone. Histopathologically, the tumor consisted of two distinct components, most of which showed the typical morphology of hemangioblastoma. However, there were a few acinar structures composed of clear cells scattered in hemangioblastoma, and these acinar structures were subsequently confirmed as clear cell RCC. The genetic testing confirmed that the patient had VHL disease with de novo somatic mutation. Based on our case report, we systematically reviewed the characteristics of collision tumor composed of hemangioblastoma and metastatic RCC in VHL patients. The special growth site of our case is the first report of this kind of collision tumor, and can also help enrich our understanding of VHL disease and collision tumor. |
| first_indexed | 2024-03-11T18:38:14Z |
| format | Article |
| id | doaj.art-ce8e80960eb1451b845be4f7bd418f21 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-03-11T18:38:14Z |
| publishDate | 2023-09-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-ce8e80960eb1451b845be4f7bd418f212023-10-12T14:38:28ZengKarger PublishersCase Reports in Oncology1662-65752023-09-0116191992910.1159/000531876531876Supratentorial Collision Tumor of Hemangioblastoma and Metastatic Clear Cell Renal Cell Carcinoma in a Patient with von Hippel-Lindau DiseaseWenjun Luo0Cuiyun Sun1Shizhu Yu2Department of Neuropathology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Neuropathology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Neuropathology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, ChinaCollision tumors are rarely reported in patients with von Hippel-Lindau (VHL) disease, even though VHL patients often present with multi-organ tumor syndromes, like hemangioblastoma and renal cell carcinoma (RCC). Hemangioblastoma is rarely located in a supratentorial location, and intracranial lateral ventricular is also not a common site of metastasis for RCC. It is extremely rare for the two tumors to collide in the supratentorial area. We report a 64-year-old man with a history of clear cell RCC who presented with a sudden headache. The brain magnetic resonance imaging revealed that there was a cystic-solid mass in the intracranial lateral ventricular trigone. Histopathologically, the tumor consisted of two distinct components, most of which showed the typical morphology of hemangioblastoma. However, there were a few acinar structures composed of clear cells scattered in hemangioblastoma, and these acinar structures were subsequently confirmed as clear cell RCC. The genetic testing confirmed that the patient had VHL disease with de novo somatic mutation. Based on our case report, we systematically reviewed the characteristics of collision tumor composed of hemangioblastoma and metastatic RCC in VHL patients. The special growth site of our case is the first report of this kind of collision tumor, and can also help enrich our understanding of VHL disease and collision tumor.https://beta.karger.com/Article/FullText/531876collision tumorvon hippel-lindau diseasehemangioblastomaclear cell renal cell carcinoma |
| spellingShingle | Wenjun Luo Cuiyun Sun Shizhu Yu Supratentorial Collision Tumor of Hemangioblastoma and Metastatic Clear Cell Renal Cell Carcinoma in a Patient with von Hippel-Lindau Disease Case Reports in Oncology collision tumor von hippel-lindau disease hemangioblastoma clear cell renal cell carcinoma |
| title | Supratentorial Collision Tumor of Hemangioblastoma and Metastatic Clear Cell Renal Cell Carcinoma in a Patient with von Hippel-Lindau Disease |
| title_full | Supratentorial Collision Tumor of Hemangioblastoma and Metastatic Clear Cell Renal Cell Carcinoma in a Patient with von Hippel-Lindau Disease |
| title_fullStr | Supratentorial Collision Tumor of Hemangioblastoma and Metastatic Clear Cell Renal Cell Carcinoma in a Patient with von Hippel-Lindau Disease |
| title_full_unstemmed | Supratentorial Collision Tumor of Hemangioblastoma and Metastatic Clear Cell Renal Cell Carcinoma in a Patient with von Hippel-Lindau Disease |
| title_short | Supratentorial Collision Tumor of Hemangioblastoma and Metastatic Clear Cell Renal Cell Carcinoma in a Patient with von Hippel-Lindau Disease |
| title_sort | supratentorial collision tumor of hemangioblastoma and metastatic clear cell renal cell carcinoma in a patient with von hippel lindau disease |
| topic | collision tumor von hippel-lindau disease hemangioblastoma clear cell renal cell carcinoma |
| url | https://beta.karger.com/Article/FullText/531876 |
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