Specific intracellular retention of circSKA3 promotes colorectal cancer metastasis by attenuating ubiquitination and degradation of SLUG

Specific intracellular retention of circSKA3 promotes colorectal cancer metastasis by attenuating ubiquitination and degradation of SLUG

Abstract Our previous study demonstrated that tumor-suppressor circular RNAs (circRNAs) can be specifically secreted outside of colorectal cancer (CRC) cells within exosomes to maintain tumor cell fitness. However, whether tumor-driving circRNAs can be specifically retained in cells to facilitate tu...

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Bibliographic Details
Main Authors: Jingwen Deng, Shaoxia Liao, Chaoyi Chen, Fengyan Han, Siqin Lei, Xuan Lai, Kehong Ye, Qizheng Han, Fang E, Chao Lu, Maode Lai, Fanlong Liu, Honghe Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06279-w

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