Vitamin D and Its Association with <i>H. pylori</i> Prevalence and Eradication: A Comprehensive Review
Taking into account previous data that sustain a relationship between vitamin D deficiency and higher <i>H. pylori</i> infection positivity rates, this review aims to assess the influence of vitamin D deficiency and/or insufficiency upon the prevalence of <i>H. pylori</i> inf...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/15/16/3549 |
| _version_ | 1797583653436391424 |
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| author | Maria Oana Săsăran Cristina Oana Mărginean Ancuta Lupu Ana Maria Koller |
| author_facet | Maria Oana Săsăran Cristina Oana Mărginean Ancuta Lupu Ana Maria Koller |
| author_sort | Maria Oana Săsăran |
| collection | DOAJ |
| description | Taking into account previous data that sustain a relationship between vitamin D deficiency and higher <i>H. pylori</i> infection positivity rates, this review aims to assess the influence of vitamin D deficiency and/or insufficiency upon the prevalence of <i>H. pylori</i> infection and its eradication success. Three major databases were searched for articles that analyzed a relationship between vitamin D status and <i>H. pylori</i> infection. The literature search retrieved a total of 37 reports, after the article selection process. Hypovitaminosis D emerged as a potential risk factor for <i>H. pylori</i> infection, given the higher prevalence of vitamin D deficiency and/or insufficiency among <i>H. pylori</i>-positive subjects. Furthermore, the same type of micronutrient deficiency has been directly linked to <i>H. pylori</i> eradication failure. An inverse linear relationship between vitamin D status and gastric cancer risk exists, but the additional involvement of <i>H. pylori</i> in this correlation is still in question. The potential benefit of oral supplements in enhancing the success of classical therapeutic regimens of <i>H. pylori</i> still requires future research. Future population-based studies from larger geographical areas are warranted to address this subject in more depth. |
| first_indexed | 2024-03-10T23:40:56Z |
| format | Article |
| id | doaj.art-ce9043232d3f47cea7dba4784ba4f101 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T23:40:56Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-ce9043232d3f47cea7dba4784ba4f1012023-11-19T02:29:32ZengMDPI AGNutrients2072-66432023-08-011516354910.3390/nu15163549Vitamin D and Its Association with <i>H. pylori</i> Prevalence and Eradication: A Comprehensive ReviewMaria Oana Săsăran0Cristina Oana Mărginean1Ancuta Lupu2Ana Maria Koller3Department of Pediatrics 3, University of Medicine, Pharmacy, Sciences and Technology George Emil Palade from Târgu Mureș, Gheorghe Marinescu Street No. 38, 540136 Târgu Mureș, RomaniaDepartment of Pediatrics 1, University of Medicine, Pharmacy, Sciences and Technology George Emil Palade from Târgu Mureș, Gheorghe Marinescu Street No. 38, 540136 Târgu Mureș, RomaniaDepartment of Pediatrics, University of Medicine and Pharmacy Gr. T. Popa Iași, Universității Street No. 16, 700115 Iași, RomaniaClinics of Pediatrics, Emergency County Clinical Hospital, Gheorghe Marinescu Street No. 50, 540136 Târgu Mureș, RomaniaTaking into account previous data that sustain a relationship between vitamin D deficiency and higher <i>H. pylori</i> infection positivity rates, this review aims to assess the influence of vitamin D deficiency and/or insufficiency upon the prevalence of <i>H. pylori</i> infection and its eradication success. Three major databases were searched for articles that analyzed a relationship between vitamin D status and <i>H. pylori</i> infection. The literature search retrieved a total of 37 reports, after the article selection process. Hypovitaminosis D emerged as a potential risk factor for <i>H. pylori</i> infection, given the higher prevalence of vitamin D deficiency and/or insufficiency among <i>H. pylori</i>-positive subjects. Furthermore, the same type of micronutrient deficiency has been directly linked to <i>H. pylori</i> eradication failure. An inverse linear relationship between vitamin D status and gastric cancer risk exists, but the additional involvement of <i>H. pylori</i> in this correlation is still in question. The potential benefit of oral supplements in enhancing the success of classical therapeutic regimens of <i>H. pylori</i> still requires future research. Future population-based studies from larger geographical areas are warranted to address this subject in more depth.https://www.mdpi.com/2072-6643/15/16/3549vitamin Ddeficiencyoral supplements<i>H. pylori</i>eradicationgastric cancer |
| spellingShingle | Maria Oana Săsăran Cristina Oana Mărginean Ancuta Lupu Ana Maria Koller Vitamin D and Its Association with <i>H. pylori</i> Prevalence and Eradication: A Comprehensive Review Nutrients vitamin D deficiency oral supplements <i>H. pylori</i> eradication gastric cancer |
| title | Vitamin D and Its Association with <i>H. pylori</i> Prevalence and Eradication: A Comprehensive Review |
| title_full | Vitamin D and Its Association with <i>H. pylori</i> Prevalence and Eradication: A Comprehensive Review |
| title_fullStr | Vitamin D and Its Association with <i>H. pylori</i> Prevalence and Eradication: A Comprehensive Review |
| title_full_unstemmed | Vitamin D and Its Association with <i>H. pylori</i> Prevalence and Eradication: A Comprehensive Review |
| title_short | Vitamin D and Its Association with <i>H. pylori</i> Prevalence and Eradication: A Comprehensive Review |
| title_sort | vitamin d and its association with i h pylori i prevalence and eradication a comprehensive review |
| topic | vitamin D deficiency oral supplements <i>H. pylori</i> eradication gastric cancer |
| url | https://www.mdpi.com/2072-6643/15/16/3549 |
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