Anti-osteopontin therapy leads to improved edema and infarct size in a murine model of ischemic stroke

Anti-osteopontin therapy leads to improved edema and infarct size in a murine model of ischemic stroke

Abstract Ischemic stroke is a serious neurological disorder that is associated with dysregulation of the neurovascular unit (NVU) and impairment of the blood–brain barrier (BBB). Paradoxically, reperfusion therapies can aggravate NVU and BBB dysfunction, leading to deleterious consequences in additi...

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Bibliographic Details
Main Authors: Daniel Spitzer, Tim Puetz, Moritz Armbrust, Maika Dunst, Jadranka Macas, Florian Croll, Karl-Heinz Plate, Yvonne Reiss, Stefan Liebner, Patrick N. Harter, Sylvaine Guérit, Kavi Devraj
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-25245-8

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