Activity of Anti-Microbial Peptides (AMPs) against <i>Leishmania</i> and Other Parasites: An Overview
Anti-microbial peptides (AMPs), small biologically active molecules, produced by different organisms through their innate immune system, have become a considerable subject of interest in the request of novel therapeutics. Most of these peptides are cationic-amphipathic, exhibiting two main mechanism...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/7/984 |
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| author | Rima El-Dirany Hawraa Shahrour Zeinab Dirany Fadi Abdel-Sater Gustavo Gonzalez-Gaitano Klaus Brandenburg Guillermo Martinez de Tejada Paul A. Nguewa |
| author_facet | Rima El-Dirany Hawraa Shahrour Zeinab Dirany Fadi Abdel-Sater Gustavo Gonzalez-Gaitano Klaus Brandenburg Guillermo Martinez de Tejada Paul A. Nguewa |
| author_sort | Rima El-Dirany |
| collection | DOAJ |
| description | Anti-microbial peptides (AMPs), small biologically active molecules, produced by different organisms through their innate immune system, have become a considerable subject of interest in the request of novel therapeutics. Most of these peptides are cationic-amphipathic, exhibiting two main mechanisms of action, direct lysis and by modulating the immunity. The most commonly reported activity of AMPs is their anti-bacterial effects, although other effects, such as anti-fungal, anti-viral, and anti-parasitic, as well as anti-tumor mechanisms of action have also been described. Their anti-parasitic effect against leishmaniasis has been studied. Leishmaniasis is a neglected tropical disease. Currently among parasitic diseases, it is the second most threating illness after malaria. Clinical treatments, mainly antimonial derivatives, are related to drug resistance and some undesirable effects. Therefore, the development of new therapeutic agents has become a priority, and AMPs constitute a promising alternative. In this work, we describe the principal families of AMPs (melittin, cecropin, cathelicidin, defensin, magainin, temporin, dermaseptin, eumenitin, and histatin) exhibiting a potential anti-leishmanial activity, as well as their effectiveness against other microorganisms. |
| first_indexed | 2024-03-10T09:45:25Z |
| format | Article |
| id | doaj.art-ce94401133d0463388e9222d047534bb |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T09:45:25Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-ce94401133d0463388e9222d047534bb2023-11-22T03:18:16ZengMDPI AGBiomolecules2218-273X2021-07-0111798410.3390/biom11070984Activity of Anti-Microbial Peptides (AMPs) against <i>Leishmania</i> and Other Parasites: An OverviewRima El-Dirany0Hawraa Shahrour1Zeinab Dirany2Fadi Abdel-Sater3Gustavo Gonzalez-Gaitano4Klaus Brandenburg5Guillermo Martinez de Tejada6Paul A. Nguewa7ISTUN Instituto de Salud Tropical, Department of Microbiology and Parasitology, IdiSNA (Navarra Institute for Health Research), University of Navarra, c/Irunlarrea 1, 31008 Pamplona, Navarra, SpainFaculty of Sciences I, Lebanese University, Hadath 1003, LebanonDepartment of Chemistry, Faculty of Sciences, University of Navarra, 31080 Pamplona, Navarra, SpainFaculty of Sciences I, Lebanese University, Hadath 1003, LebanonDepartment of Chemistry, Faculty of Sciences, University of Navarra, 31080 Pamplona, Navarra, SpainBrandenburg Antiinfektiva GmbH, c/o Forschungszentrum Borstel, Leibniz Lungenzentrum, 23845 Borstel, GermanyDepartment of Microbiology and Parasitology, IdiSNA (Navarra Institute for Health Research), University of Navarra, 31008 Pamplona, Navarra, SpainISTUN Instituto de Salud Tropical, Department of Microbiology and Parasitology, IdiSNA (Navarra Institute for Health Research), University of Navarra, c/Irunlarrea 1, 31008 Pamplona, Navarra, SpainAnti-microbial peptides (AMPs), small biologically active molecules, produced by different organisms through their innate immune system, have become a considerable subject of interest in the request of novel therapeutics. Most of these peptides are cationic-amphipathic, exhibiting two main mechanisms of action, direct lysis and by modulating the immunity. The most commonly reported activity of AMPs is their anti-bacterial effects, although other effects, such as anti-fungal, anti-viral, and anti-parasitic, as well as anti-tumor mechanisms of action have also been described. Their anti-parasitic effect against leishmaniasis has been studied. Leishmaniasis is a neglected tropical disease. Currently among parasitic diseases, it is the second most threating illness after malaria. Clinical treatments, mainly antimonial derivatives, are related to drug resistance and some undesirable effects. Therefore, the development of new therapeutic agents has become a priority, and AMPs constitute a promising alternative. In this work, we describe the principal families of AMPs (melittin, cecropin, cathelicidin, defensin, magainin, temporin, dermaseptin, eumenitin, and histatin) exhibiting a potential anti-leishmanial activity, as well as their effectiveness against other microorganisms.https://www.mdpi.com/2218-273X/11/7/984anti-microbial peptides (AMPs)anti-bacterialanti-fungalanti-viralanti-parasiticanti-tumor |
| spellingShingle | Rima El-Dirany Hawraa Shahrour Zeinab Dirany Fadi Abdel-Sater Gustavo Gonzalez-Gaitano Klaus Brandenburg Guillermo Martinez de Tejada Paul A. Nguewa Activity of Anti-Microbial Peptides (AMPs) against <i>Leishmania</i> and Other Parasites: An Overview Biomolecules anti-microbial peptides (AMPs) anti-bacterial anti-fungal anti-viral anti-parasitic anti-tumor |
| title | Activity of Anti-Microbial Peptides (AMPs) against <i>Leishmania</i> and Other Parasites: An Overview |
| title_full | Activity of Anti-Microbial Peptides (AMPs) against <i>Leishmania</i> and Other Parasites: An Overview |
| title_fullStr | Activity of Anti-Microbial Peptides (AMPs) against <i>Leishmania</i> and Other Parasites: An Overview |
| title_full_unstemmed | Activity of Anti-Microbial Peptides (AMPs) against <i>Leishmania</i> and Other Parasites: An Overview |
| title_short | Activity of Anti-Microbial Peptides (AMPs) against <i>Leishmania</i> and Other Parasites: An Overview |
| title_sort | activity of anti microbial peptides amps against i leishmania i and other parasites an overview |
| topic | anti-microbial peptides (AMPs) anti-bacterial anti-fungal anti-viral anti-parasitic anti-tumor |
| url | https://www.mdpi.com/2218-273X/11/7/984 |
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