SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF SOME SCHIFF BASES DERIVED FROM 2-AMINOTHIAZOLE DERIVATIVES
Various substituted acetophenones (1-5) on treatment with iodine and thiourea yielded 2-amino-4-(substituted-phenyl)thiazole (1a-5a), which on further treatment with various substituted aldehydes to get N-(substitutedbenzylidene)-4(substitutedphenyl)thiazol-2-amine (1b-5b). All the synthesized compo...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universitas Gadjah Mada
2013-01-01
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| Series: | Indonesian Journal of Pharmacy |
| Subjects: | |
| Online Access: | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/513/391 |
| _version_ | 1818208516814405632 |
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| author | Rajul Gupta Neeraj Kumar Fuloria Shivkanya Fuloria |
| author_facet | Rajul Gupta Neeraj Kumar Fuloria Shivkanya Fuloria |
| author_sort | Rajul Gupta |
| collection | DOAJ |
| description | Various substituted acetophenones (1-5) on treatment with iodine and thiourea yielded 2-amino-4-(substituted-phenyl)thiazole (1a-5a), which on further treatment with various substituted aldehydes to get N-(substitutedbenzylidene)-4(substitutedphenyl)thiazol-2-amine (1b-5b). All the synthesized compounds were characterized by their respective FTIR, H NMR and Mass data. Synthesized compounds (1b-5b) were subjected to investigation for their antibacterial and antifungal studies against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Asperigillus flavus and Asperigillus fumigatus by disk diffusion method. Compound 5b was found to be most effective with largest zone of inhibition. |
| first_indexed | 2024-12-12T04:46:04Z |
| format | Article |
| id | doaj.art-ce9791213dc34dcb9db49aebd587dfca |
| institution | Directory Open Access Journal |
| issn | 2338-9427 2338-9486 |
| language | English |
| last_indexed | 2024-12-12T04:46:04Z |
| publishDate | 2013-01-01 |
| publisher | Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Pharmacy |
| spelling | doaj.art-ce9791213dc34dcb9db49aebd587dfca2022-12-22T00:37:38ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862013-01-012413539http://dx.doi.org/10.14499/indonesianjpharm24iss1pp35-39SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF SOME SCHIFF BASES DERIVED FROM 2-AMINOTHIAZOLE DERIVATIVESRajul Gupta0Neeraj Kumar Fuloria1Shivkanya Fuloria2Dept. of Pharmacy, CMJ University, Modrina Mansion, Laitumkhrah, Shillong, Meghalaya-793 003, IndiaDept. of Pharmaceutical Chemistry, Anuradha College of Pharmacy, Chikhli, Dist. Buldana, Maharashtra, 443201, IndiaDept. of Pharmaceutical Chemistry, Anuradha College of Pharmacy, Chikhli, Dist. Buldana, Maharashtra, 443201, IndiaVarious substituted acetophenones (1-5) on treatment with iodine and thiourea yielded 2-amino-4-(substituted-phenyl)thiazole (1a-5a), which on further treatment with various substituted aldehydes to get N-(substitutedbenzylidene)-4(substitutedphenyl)thiazol-2-amine (1b-5b). All the synthesized compounds were characterized by their respective FTIR, H NMR and Mass data. Synthesized compounds (1b-5b) were subjected to investigation for their antibacterial and antifungal studies against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Asperigillus flavus and Asperigillus fumigatus by disk diffusion method. Compound 5b was found to be most effective with largest zone of inhibition.http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/513/391ThiazoleAcetophenones AntibacterialAntifungalSubstituted Aldehydes |
| spellingShingle | Rajul Gupta Neeraj Kumar Fuloria Shivkanya Fuloria SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF SOME SCHIFF BASES DERIVED FROM 2-AMINOTHIAZOLE DERIVATIVES Indonesian Journal of Pharmacy Thiazole Acetophenones Antibacterial Antifungal Substituted Aldehydes |
| title | SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF SOME SCHIFF BASES DERIVED FROM 2-AMINOTHIAZOLE DERIVATIVES |
| title_full | SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF SOME SCHIFF BASES DERIVED FROM 2-AMINOTHIAZOLE DERIVATIVES |
| title_fullStr | SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF SOME SCHIFF BASES DERIVED FROM 2-AMINOTHIAZOLE DERIVATIVES |
| title_full_unstemmed | SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF SOME SCHIFF BASES DERIVED FROM 2-AMINOTHIAZOLE DERIVATIVES |
| title_short | SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF SOME SCHIFF BASES DERIVED FROM 2-AMINOTHIAZOLE DERIVATIVES |
| title_sort | synthesis and antimicrobial activity evaluation of some schiff bases derived from 2 aminothiazole derivatives |
| topic | Thiazole Acetophenones Antibacterial Antifungal Substituted Aldehydes |
| url | http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/513/391 |
| work_keys_str_mv | AT rajulgupta synthesisandantimicrobialactivityevaluationofsomeschiffbasesderivedfrom2aminothiazolederivatives AT neerajkumarfuloria synthesisandantimicrobialactivityevaluationofsomeschiffbasesderivedfrom2aminothiazolederivatives AT shivkanyafuloria synthesisandantimicrobialactivityevaluationofsomeschiffbasesderivedfrom2aminothiazolederivatives |