Perspective: Aligned arrays of electrospun nanofibers for directing cell migration
Cell migration plays an important role in a wide variety of biological processes, including embryogenesis, wound healing, inflammation, cancer metastasis, and tissue repair. Electrospun nanofibers have been extensively explored as scaffolds to manipulate cell migration owing to their unique characte...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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AIP Publishing LLC
2018-12-01
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| Series: | APL Materials |
| Online Access: | http://dx.doi.org/10.1063/1.5058083 |
| _version_ | 1819330866861572096 |
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| author | Jiajia Xue Tong Wu Younan Xia |
| author_facet | Jiajia Xue Tong Wu Younan Xia |
| author_sort | Jiajia Xue |
| collection | DOAJ |
| description | Cell migration plays an important role in a wide variety of biological processes, including embryogenesis, wound healing, inflammation, cancer metastasis, and tissue repair. Electrospun nanofibers have been extensively explored as scaffolds to manipulate cell migration owing to their unique characteristics in mimicking the hierarchical architecture of extracellular matrix. In particular, aligned arrays of electrospun nanofibers are capable of guiding and promoting the directional migration of cells. The physical parameters and properties of the aligned nanofibers, including their size, modulus, and surface chemistry, can all affect the migratory behaviors of cells, while the controlled release of growth factors and drugs from the nanofibers can also be utilized to influence cell migration. By manipulating cell migration, electrospun nanofibers have been applied to promote tissue repair and help eradicate tumors in vivo. In this perspective, we highlight recent developments in collecting electrospun nanofibers as aligned arrays and then illustrate how the aligned nanofibers can be utilized to manipulate cell migration. |
| first_indexed | 2024-12-24T14:05:20Z |
| format | Article |
| id | doaj.art-ce9856cea70348edbdca9ae691b0c4e0 |
| institution | Directory Open Access Journal |
| issn | 2166-532X |
| language | English |
| last_indexed | 2024-12-24T14:05:20Z |
| publishDate | 2018-12-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Materials |
| spelling | doaj.art-ce9856cea70348edbdca9ae691b0c4e02022-12-21T16:52:22ZengAIP Publishing LLCAPL Materials2166-532X2018-12-01612120902120902-1510.1063/1.5058083005812APMPerspective: Aligned arrays of electrospun nanofibers for directing cell migrationJiajia Xue0Tong Wu1Younan Xia2The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USAThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USAThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USACell migration plays an important role in a wide variety of biological processes, including embryogenesis, wound healing, inflammation, cancer metastasis, and tissue repair. Electrospun nanofibers have been extensively explored as scaffolds to manipulate cell migration owing to their unique characteristics in mimicking the hierarchical architecture of extracellular matrix. In particular, aligned arrays of electrospun nanofibers are capable of guiding and promoting the directional migration of cells. The physical parameters and properties of the aligned nanofibers, including their size, modulus, and surface chemistry, can all affect the migratory behaviors of cells, while the controlled release of growth factors and drugs from the nanofibers can also be utilized to influence cell migration. By manipulating cell migration, electrospun nanofibers have been applied to promote tissue repair and help eradicate tumors in vivo. In this perspective, we highlight recent developments in collecting electrospun nanofibers as aligned arrays and then illustrate how the aligned nanofibers can be utilized to manipulate cell migration.http://dx.doi.org/10.1063/1.5058083 |
| spellingShingle | Jiajia Xue Tong Wu Younan Xia Perspective: Aligned arrays of electrospun nanofibers for directing cell migration APL Materials |
| title | Perspective: Aligned arrays of electrospun nanofibers for directing cell migration |
| title_full | Perspective: Aligned arrays of electrospun nanofibers for directing cell migration |
| title_fullStr | Perspective: Aligned arrays of electrospun nanofibers for directing cell migration |
| title_full_unstemmed | Perspective: Aligned arrays of electrospun nanofibers for directing cell migration |
| title_short | Perspective: Aligned arrays of electrospun nanofibers for directing cell migration |
| title_sort | perspective aligned arrays of electrospun nanofibers for directing cell migration |
| url | http://dx.doi.org/10.1063/1.5058083 |
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