Uterine Transcriptome: Understanding Physiology and Disease Processes
In recent years, transcriptomics has enabled us to gain a deeper understanding of fundamental reproductive physiology, including the menstrual cycle, through a more precise molecular analysis. The endometrial mRNA transcript levels fluctuate during the normal menstrual cycle, indicating changes in t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/4/634 |
| _version_ | 1797606313257074688 |
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| author | Gregory W. Kirschen Kamran Hessami Abdelrahman AlAshqar Sadia Afrin Bethlehem Lulseged Mostafa Borahay |
| author_facet | Gregory W. Kirschen Kamran Hessami Abdelrahman AlAshqar Sadia Afrin Bethlehem Lulseged Mostafa Borahay |
| author_sort | Gregory W. Kirschen |
| collection | DOAJ |
| description | In recent years, transcriptomics has enabled us to gain a deeper understanding of fundamental reproductive physiology, including the menstrual cycle, through a more precise molecular analysis. The endometrial mRNA transcript levels fluctuate during the normal menstrual cycle, indicating changes in the relative recruitment and abundance of inflammatory cells, as well as changes in the receptivity and remodeling of the endometrium. In addition to providing a more comprehensive understanding of the molecular underpinnings of pathological gynecological conditions such as endometriosis, leiomyomas, and adenomyosis through RNA sequencing, this has allowed researchers to create transcriptome profiles during both normal menstrual cycles and pathological gynecological conditions. Such insights could potentially lead to more targeted and personalized therapies for benign gynecological conditions. Here, we provide an overview of recent advances in transcriptome analysis of normal and pathological endometrium. |
| first_indexed | 2024-03-11T05:13:26Z |
| format | Article |
| id | doaj.art-ce99286e5e9143c1942548886eccd636 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-11T05:13:26Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-ce99286e5e9143c1942548886eccd6362023-11-17T18:25:00ZengMDPI AGBiology2079-77372023-04-0112463410.3390/biology12040634Uterine Transcriptome: Understanding Physiology and Disease ProcessesGregory W. Kirschen0Kamran Hessami1Abdelrahman AlAshqar2Sadia Afrin3Bethlehem Lulseged4Mostafa Borahay5Department of Gynecology & Obstetrics, Johns Hopkins University, Baltimore, MD 21287, USAMaternal Fetal Care Center, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT 06510, USADepartment of Gynecology & Obstetrics, Johns Hopkins University, Baltimore, MD 21287, USASchool of Medicine, Johns Hopkins University, Baltimore, MD 21205, USADepartment of Gynecology & Obstetrics, Johns Hopkins University, Baltimore, MD 21287, USAIn recent years, transcriptomics has enabled us to gain a deeper understanding of fundamental reproductive physiology, including the menstrual cycle, through a more precise molecular analysis. The endometrial mRNA transcript levels fluctuate during the normal menstrual cycle, indicating changes in the relative recruitment and abundance of inflammatory cells, as well as changes in the receptivity and remodeling of the endometrium. In addition to providing a more comprehensive understanding of the molecular underpinnings of pathological gynecological conditions such as endometriosis, leiomyomas, and adenomyosis through RNA sequencing, this has allowed researchers to create transcriptome profiles during both normal menstrual cycles and pathological gynecological conditions. Such insights could potentially lead to more targeted and personalized therapies for benign gynecological conditions. Here, we provide an overview of recent advances in transcriptome analysis of normal and pathological endometrium.https://www.mdpi.com/2079-7737/12/4/634transcriptomicsleiomyomasfibroidsendometriosismRNAmicroRNA |
| spellingShingle | Gregory W. Kirschen Kamran Hessami Abdelrahman AlAshqar Sadia Afrin Bethlehem Lulseged Mostafa Borahay Uterine Transcriptome: Understanding Physiology and Disease Processes Biology transcriptomics leiomyomas fibroids endometriosis mRNA microRNA |
| title | Uterine Transcriptome: Understanding Physiology and Disease Processes |
| title_full | Uterine Transcriptome: Understanding Physiology and Disease Processes |
| title_fullStr | Uterine Transcriptome: Understanding Physiology and Disease Processes |
| title_full_unstemmed | Uterine Transcriptome: Understanding Physiology and Disease Processes |
| title_short | Uterine Transcriptome: Understanding Physiology and Disease Processes |
| title_sort | uterine transcriptome understanding physiology and disease processes |
| topic | transcriptomics leiomyomas fibroids endometriosis mRNA microRNA |
| url | https://www.mdpi.com/2079-7737/12/4/634 |
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