Synthesis, Structure and Biological Activity Studies of New Metal Ion Complexes Based on 3-[(3-Hydroxynaphthalene-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one
In the present study, a novel ligand (L) made of 2-hydroxynaphthaldehyde and 3-hydrazone-1,3-dihydro-indole-2-one(3-[(3-hydroxynaphthalen-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one). The ligand was characterized by FTIR, UV-vis, mass, 1H-NMR, 13C-NMR, and CHN elemental analysis. New complex...
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| Format: | Article |
| Language: | English |
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Department of Chemistry, Universitas Gadjah Mada
2024-04-01
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| Series: | Indonesian Journal of Chemistry |
| Subjects: | |
| Online Access: | https://journal.ugm.ac.id/ijc/article/view/87359 |
| _version_ | 1797232855565205504 |
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| author | Safa Sami Naser Shaalan |
| author_facet | Safa Sami Naser Shaalan |
| author_sort | Safa Sami |
| collection | DOAJ |
| description | In the present study, a novel ligand (L) made of 2-hydroxynaphthaldehyde and 3-hydrazone-1,3-dihydro-indole-2-one(3-[(3-hydroxynaphthalen-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one). The ligand was characterized by FTIR, UV-vis, mass, 1H-NMR, 13C-NMR, and CHN elemental analysis. New complexes of this ligand were created by treating methanol and a drop of DMF solution of the produced ligand with the hydrated metal salts of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) in a molar ratio of 2:1 (L:M). As a result, complexes have been emerged and identified FTIR, UV-vis, C.H.N., chloride-containing, molar conductance, magnetic susceptibility, and atomic absorption. The characterization result for each complex indicated complexes with octahedral coordination geometry and tridentates with metal to ligand ratios of 1:2. The biological activities of the new compounds were examined against Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus) giving an acceptable inhibition efficiency. |
| first_indexed | 2024-04-24T16:06:54Z |
| format | Article |
| id | doaj.art-ce9942cefbe246f199a8f427f5b0e1bf |
| institution | Directory Open Access Journal |
| issn | 1411-9420 2460-1578 |
| language | English |
| last_indexed | 2024-04-24T16:06:54Z |
| publishDate | 2024-04-01 |
| publisher | Department of Chemistry, Universitas Gadjah Mada |
| record_format | Article |
| series | Indonesian Journal of Chemistry |
| spelling | doaj.art-ce9942cefbe246f199a8f427f5b0e1bf2024-04-01T04:11:24ZengDepartment of Chemistry, Universitas Gadjah MadaIndonesian Journal of Chemistry1411-94202460-15782024-04-0124237037810.22146/ijc.8735935280Synthesis, Structure and Biological Activity Studies of New Metal Ion Complexes Based on 3-[(3-Hydroxynaphthalene-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-oneSafa Sami0Naser Shaalan1Department of Chemistry, College of Science for Women, University of Baghdad, Baghdad 10071, IraqDepartment of Chemistry, College of Science for Women, University of Baghdad, Baghdad 10071, IraqIn the present study, a novel ligand (L) made of 2-hydroxynaphthaldehyde and 3-hydrazone-1,3-dihydro-indole-2-one(3-[(3-hydroxynaphthalen-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one). The ligand was characterized by FTIR, UV-vis, mass, 1H-NMR, 13C-NMR, and CHN elemental analysis. New complexes of this ligand were created by treating methanol and a drop of DMF solution of the produced ligand with the hydrated metal salts of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) in a molar ratio of 2:1 (L:M). As a result, complexes have been emerged and identified FTIR, UV-vis, C.H.N., chloride-containing, molar conductance, magnetic susceptibility, and atomic absorption. The characterization result for each complex indicated complexes with octahedral coordination geometry and tridentates with metal to ligand ratios of 1:2. The biological activities of the new compounds were examined against Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus) giving an acceptable inhibition efficiency.https://journal.ugm.ac.id/ijc/article/view/87359biological activitiesisatinmetal complexesschiff base2-hydroxynaphthaldehyde |
| spellingShingle | Safa Sami Naser Shaalan Synthesis, Structure and Biological Activity Studies of New Metal Ion Complexes Based on 3-[(3-Hydroxynaphthalene-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one Indonesian Journal of Chemistry biological activities isatin metal complexes schiff base 2-hydroxynaphthaldehyde |
| title | Synthesis, Structure and Biological Activity Studies of New Metal Ion Complexes Based on 3-[(3-Hydroxynaphthalene-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one |
| title_full | Synthesis, Structure and Biological Activity Studies of New Metal Ion Complexes Based on 3-[(3-Hydroxynaphthalene-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one |
| title_fullStr | Synthesis, Structure and Biological Activity Studies of New Metal Ion Complexes Based on 3-[(3-Hydroxynaphthalene-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one |
| title_full_unstemmed | Synthesis, Structure and Biological Activity Studies of New Metal Ion Complexes Based on 3-[(3-Hydroxynaphthalene-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one |
| title_short | Synthesis, Structure and Biological Activity Studies of New Metal Ion Complexes Based on 3-[(3-Hydroxynaphthalene-2-yl-ethylidene)-hydrazono]-1,3-dihydro-indol-2-one |
| title_sort | synthesis structure and biological activity studies of new metal ion complexes based on 3 3 hydroxynaphthalene 2 yl ethylidene hydrazono 1 3 dihydro indol 2 one |
| topic | biological activities isatin metal complexes schiff base 2-hydroxynaphthaldehyde |
| url | https://journal.ugm.ac.id/ijc/article/view/87359 |
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