The Role of BiP Retrieval by the KDEL Receptor in the Early Secretory Pathway and its Effect on Protein Quality Control and Neurodegeneration

The Role of BiP Retrieval by the KDEL Receptor in the Early Secretory Pathway and its Effect on Protein Quality Control and Neurodegeneration

Protein quality control in the early secretory pathway is a ubiquitous eukaryotic mechanism for adaptation to endoplasmic reticulum (ER) stress. An ER molecular chaperone, immunoglobulin heavy chain-binding protein (BiP), is one of the essential components in this process. BiP interacts with nascent...

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Bibliographic Details
Main Authors: Hisayo Jin, Mari Komita, Tomohiko Aoe
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
ER (endoplasmic reticulum) stress
KDEL receptor
BiP
chaperones
neurodegeneration
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00222/full

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