Long-term potentiation at CA3-CA1 hippocampal synapse with special emphasis on aging, disease, and stress
Synaptic plasticity in the mammalian central nervous system has been the subject of intense investigation for the past four decades. Long-term potentiation (LTP), a major reflection of synaptic plasticity, is an activity-driven long-lasting increase in the efficacy of excitatory synaptic transmissio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-05-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2011.00007/full |
| _version_ | 1818612316568027136 |
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| author | Ashok eKumar |
| author_facet | Ashok eKumar |
| author_sort | Ashok eKumar |
| collection | DOAJ |
| description | Synaptic plasticity in the mammalian central nervous system has been the subject of intense investigation for the past four decades. Long-term potentiation (LTP), a major reflection of synaptic plasticity, is an activity-driven long-lasting increase in the efficacy of excitatory synaptic transmission following the delivery of a brief, high-frequency train of electrical stimulation. LTP is regarded as a principal candidate for the cellular mechanisms involved in learning and offers an attractive hypothesis of how memories are constructed. There are a number of exceptional full-length reviews published on LTP; the current review intends to present an overview of the research findings regarding hippocampal LTP with special emphasis on aging, diseases, and psychological insults. |
| first_indexed | 2024-12-16T15:44:17Z |
| format | Article |
| id | doaj.art-ce9aaea2f6ad46269166a4738a0dc4f2 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-16T15:44:17Z |
| publishDate | 2011-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-ce9aaea2f6ad46269166a4738a0dc4f22022-12-21T22:25:51ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652011-05-01310.3389/fnagi.2011.0000710748Long-term potentiation at CA3-CA1 hippocampal synapse with special emphasis on aging, disease, and stressAshok eKumar0University of FloridaSynaptic plasticity in the mammalian central nervous system has been the subject of intense investigation for the past four decades. Long-term potentiation (LTP), a major reflection of synaptic plasticity, is an activity-driven long-lasting increase in the efficacy of excitatory synaptic transmission following the delivery of a brief, high-frequency train of electrical stimulation. LTP is regarded as a principal candidate for the cellular mechanisms involved in learning and offers an attractive hypothesis of how memories are constructed. There are a number of exceptional full-length reviews published on LTP; the current review intends to present an overview of the research findings regarding hippocampal LTP with special emphasis on aging, diseases, and psychological insults.http://journal.frontiersin.org/Journal/10.3389/fnagi.2011.00007/fullAgingHippocampusLong-Term Potentiationstressafterhyperpolarization |
| spellingShingle | Ashok eKumar Long-term potentiation at CA3-CA1 hippocampal synapse with special emphasis on aging, disease, and stress Frontiers in Aging Neuroscience Aging Hippocampus Long-Term Potentiation stress afterhyperpolarization |
| title | Long-term potentiation at CA3-CA1 hippocampal synapse with special emphasis on aging, disease, and stress |
| title_full | Long-term potentiation at CA3-CA1 hippocampal synapse with special emphasis on aging, disease, and stress |
| title_fullStr | Long-term potentiation at CA3-CA1 hippocampal synapse with special emphasis on aging, disease, and stress |
| title_full_unstemmed | Long-term potentiation at CA3-CA1 hippocampal synapse with special emphasis on aging, disease, and stress |
| title_short | Long-term potentiation at CA3-CA1 hippocampal synapse with special emphasis on aging, disease, and stress |
| title_sort | long term potentiation at ca3 ca1 hippocampal synapse with special emphasis on aging disease and stress |
| topic | Aging Hippocampus Long-Term Potentiation stress afterhyperpolarization |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2011.00007/full |
| work_keys_str_mv | AT ashokekumar longtermpotentiationatca3ca1hippocampalsynapsewithspecialemphasisonagingdiseaseandstress |