Abnormal methylation caused by folic acid deficiency in neural tube defects
Neural tube closure disorders, including anencephaly, spina bifida, and encephalocele, cause neural tube defects (NTDs). This congenital disability remained not only a major contributor to the prevalence of stillbirths and neonatal deaths but also a significant cause of lifelong physical disability...
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-12-01
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| Series: | Open Life Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/biol-2022-0504 |
| _version_ | 1797947709831774208 |
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| author | Cao Rui Xie Jun Zhang Li |
| author_facet | Cao Rui Xie Jun Zhang Li |
| author_sort | Cao Rui |
| collection | DOAJ |
| description | Neural tube closure disorders, including anencephaly, spina bifida, and encephalocele, cause neural tube defects (NTDs). This congenital disability remained not only a major contributor to the prevalence of stillbirths and neonatal deaths but also a significant cause of lifelong physical disability in surviving infants. NTDs are complex diseases caused by multiple etiologies, levels, and mechanisms. Currently, the pathogenesis of NTDs is considered to be associated with both genetic and environmental factors. Here, we aimed to review the research progress on the etiology and mechanism of NTDs induced by methylation modification caused by folic acid deficiency. Folic acid supplementation in the diet is reported to be beneficial in preventing NTDs. Methylation modification is one of the most important epigenetic modifications crucial for brain neurodevelopment. Disturbances in folic acid metabolism and decreased S-adenosylmethionine levels lead to reduced methyl donors and methylation modification disorders. In this review, we summarized the relationship between NTDs, folic acid metabolism, and related methylation of DNA, imprinted genes, cytoskeletal protein, histone, RNA, and non-coding RNA, so as to clarify the role of folic acid and methylation in NTDs and to better understand the various pathogenesis mechanisms of NTDs and the effective prevention. |
| first_indexed | 2024-04-10T21:32:06Z |
| format | Article |
| id | doaj.art-ce9b40f59ef3411bb8bf14b413d91cef |
| institution | Directory Open Access Journal |
| issn | 2391-5412 |
| language | English |
| last_indexed | 2024-04-10T21:32:06Z |
| publishDate | 2022-12-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Life Sciences |
| spelling | doaj.art-ce9b40f59ef3411bb8bf14b413d91cef2023-01-19T13:20:30ZengDe GruyterOpen Life Sciences2391-54122022-12-011711679168810.1515/biol-2022-0504Abnormal methylation caused by folic acid deficiency in neural tube defectsCao Rui0Xie Jun1Zhang Li2Department of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Key Laboratory for Cellular Physiology of Ministry of Education, Shanxi Medical University, No. 56, Xinjian South Road, Yingze District, Taiyuan, Shanxi Province, ChinaDepartment of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Key Laboratory for Cellular Physiology of Ministry of Education, Shanxi Medical University, No. 56, Xinjian South Road, Yingze District, Taiyuan, Shanxi Province, ChinaDepartment of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Key Laboratory for Cellular Physiology of Ministry of Education, Shanxi Medical University, No. 56, Xinjian South Road, Yingze District, Taiyuan, Shanxi Province, ChinaNeural tube closure disorders, including anencephaly, spina bifida, and encephalocele, cause neural tube defects (NTDs). This congenital disability remained not only a major contributor to the prevalence of stillbirths and neonatal deaths but also a significant cause of lifelong physical disability in surviving infants. NTDs are complex diseases caused by multiple etiologies, levels, and mechanisms. Currently, the pathogenesis of NTDs is considered to be associated with both genetic and environmental factors. Here, we aimed to review the research progress on the etiology and mechanism of NTDs induced by methylation modification caused by folic acid deficiency. Folic acid supplementation in the diet is reported to be beneficial in preventing NTDs. Methylation modification is one of the most important epigenetic modifications crucial for brain neurodevelopment. Disturbances in folic acid metabolism and decreased S-adenosylmethionine levels lead to reduced methyl donors and methylation modification disorders. In this review, we summarized the relationship between NTDs, folic acid metabolism, and related methylation of DNA, imprinted genes, cytoskeletal protein, histone, RNA, and non-coding RNA, so as to clarify the role of folic acid and methylation in NTDs and to better understand the various pathogenesis mechanisms of NTDs and the effective prevention.https://doi.org/10.1515/biol-2022-0504neural tube defectsdna methylationhistone methylationm6a rna methylationfolic acid |
| spellingShingle | Cao Rui Xie Jun Zhang Li Abnormal methylation caused by folic acid deficiency in neural tube defects Open Life Sciences neural tube defects dna methylation histone methylation m6a rna methylation folic acid |
| title | Abnormal methylation caused by folic acid deficiency in neural tube defects |
| title_full | Abnormal methylation caused by folic acid deficiency in neural tube defects |
| title_fullStr | Abnormal methylation caused by folic acid deficiency in neural tube defects |
| title_full_unstemmed | Abnormal methylation caused by folic acid deficiency in neural tube defects |
| title_short | Abnormal methylation caused by folic acid deficiency in neural tube defects |
| title_sort | abnormal methylation caused by folic acid deficiency in neural tube defects |
| topic | neural tube defects dna methylation histone methylation m6a rna methylation folic acid |
| url | https://doi.org/10.1515/biol-2022-0504 |
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