Acetazolamide and SGLT2 inhibitor as potent drugs for a patient with diabetes mellitus and worsening chronic lymphedema: A case report
Treatment of lymphedema using a pharmacologic approach is reported to have limited efficacy. Here, I report a patient with type 2 diabetes (T2DM) and acute worsening of her chronic lymphedema, in whom treatment with acetazolamide and a sodiumglucose cotransporter-2 inhibitor (SGLT2i) effectively imp...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2020-06-01
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| Series: | Veins and Lymphatics |
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| Online Access: | https://www.pagepressjournals.org/index.php/vl/article/view/8889 |
| _version_ | 1818824275593789440 |
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| author | Hajime Kataoka |
| author_facet | Hajime Kataoka |
| author_sort | Hajime Kataoka |
| collection | DOAJ |
| description | Treatment of lymphedema using a pharmacologic approach is reported to have limited efficacy. Here, I report a patient with type 2 diabetes (T2DM) and acute worsening of her chronic lymphedema, in whom treatment with acetazolamide and a sodiumglucose cotransporter-2 inhibitor (SGLT2i) effectively improved the lymphedema. A 94-year-old woman, who was treated for T2DM, hyperlipidemia, and hypertension for 17 years at my hospital presented to the emergency room because of acute worsening of her chronic right leg lymphedema with increased swelling, tightness, and dull aching. A pharmacologic approach was used to treat her worsening lymphedema. Acetazolamide 500 mg/d was administered to treat the acute tissue fluid collection in the right lymphedematous leg. Ten days later, the patient’s body weight was markedly reduced by 3.2 kg, pitting in the right leg was markedly improved, and the circumference of right limb was decreased. On day 11, the glucose-lowering agent vildagliptin was switched to the SGLT2i empagliflozin 10 mg/d. On day 70, her body weight had decreased further by 2.8 kg, and the circumference of her right limb was greatly reduced compared with that under treatment with acetazolamide. Her serum chloride concentration was increased after treatment, but her hemoglobin and hematocrit values did not change during the study period. In conclusion, acetazolamide and an SGLT2i have acute diuretic effects for draining the excess tissue fluid in the lymphedematous limb without vascular contraction by enhancing vascular tonicity. Additionally, an SGLT2i may have chronic effects for reducing fat deposits in the lymphedematous limb. |
| first_indexed | 2024-12-18T23:53:17Z |
| format | Article |
| id | doaj.art-ce9b6d49d4d6493ea76fccd88c20349e |
| institution | Directory Open Access Journal |
| issn | 2279-7483 |
| language | English |
| last_indexed | 2024-12-18T23:53:17Z |
| publishDate | 2020-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Veins and Lymphatics |
| spelling | doaj.art-ce9b6d49d4d6493ea76fccd88c20349e2022-12-21T20:46:50ZengPAGEPress PublicationsVeins and Lymphatics2279-74832020-06-019110.4081/vl.2020.8889Acetazolamide and SGLT2 inhibitor as potent drugs for a patient with diabetes mellitus and worsening chronic lymphedema: A case reportHajime Kataoka0Division of Internal Medicine, Nishida Hospital, Saiki-city, OitaTreatment of lymphedema using a pharmacologic approach is reported to have limited efficacy. Here, I report a patient with type 2 diabetes (T2DM) and acute worsening of her chronic lymphedema, in whom treatment with acetazolamide and a sodiumglucose cotransporter-2 inhibitor (SGLT2i) effectively improved the lymphedema. A 94-year-old woman, who was treated for T2DM, hyperlipidemia, and hypertension for 17 years at my hospital presented to the emergency room because of acute worsening of her chronic right leg lymphedema with increased swelling, tightness, and dull aching. A pharmacologic approach was used to treat her worsening lymphedema. Acetazolamide 500 mg/d was administered to treat the acute tissue fluid collection in the right lymphedematous leg. Ten days later, the patient’s body weight was markedly reduced by 3.2 kg, pitting in the right leg was markedly improved, and the circumference of right limb was decreased. On day 11, the glucose-lowering agent vildagliptin was switched to the SGLT2i empagliflozin 10 mg/d. On day 70, her body weight had decreased further by 2.8 kg, and the circumference of her right limb was greatly reduced compared with that under treatment with acetazolamide. Her serum chloride concentration was increased after treatment, but her hemoglobin and hematocrit values did not change during the study period. In conclusion, acetazolamide and an SGLT2i have acute diuretic effects for draining the excess tissue fluid in the lymphedematous limb without vascular contraction by enhancing vascular tonicity. Additionally, an SGLT2i may have chronic effects for reducing fat deposits in the lymphedematous limb.https://www.pagepressjournals.org/index.php/vl/article/view/8889Case reportlymphedemaacetazolamideSGLT2 inhibitorfat deposit. |
| spellingShingle | Hajime Kataoka Acetazolamide and SGLT2 inhibitor as potent drugs for a patient with diabetes mellitus and worsening chronic lymphedema: A case report Veins and Lymphatics Case report lymphedema acetazolamide SGLT2 inhibitor fat deposit. |
| title | Acetazolamide and SGLT2 inhibitor as potent drugs for a patient with diabetes mellitus and worsening chronic lymphedema: A case report |
| title_full | Acetazolamide and SGLT2 inhibitor as potent drugs for a patient with diabetes mellitus and worsening chronic lymphedema: A case report |
| title_fullStr | Acetazolamide and SGLT2 inhibitor as potent drugs for a patient with diabetes mellitus and worsening chronic lymphedema: A case report |
| title_full_unstemmed | Acetazolamide and SGLT2 inhibitor as potent drugs for a patient with diabetes mellitus and worsening chronic lymphedema: A case report |
| title_short | Acetazolamide and SGLT2 inhibitor as potent drugs for a patient with diabetes mellitus and worsening chronic lymphedema: A case report |
| title_sort | acetazolamide and sglt2 inhibitor as potent drugs for a patient with diabetes mellitus and worsening chronic lymphedema a case report |
| topic | Case report lymphedema acetazolamide SGLT2 inhibitor fat deposit. |
| url | https://www.pagepressjournals.org/index.php/vl/article/view/8889 |
| work_keys_str_mv | AT hajimekataoka acetazolamideandsglt2inhibitoraspotentdrugsforapatientwithdiabetesmellitusandworseningchroniclymphedemaacasereport |