Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation
<p>Abstract</p> <p>Background</p> <p>Prolonged weaning from mechanical ventilation has a major impact on ICU bed occupancy and patient outcome, and has significant cost implications.</p> <p>There is evidence in patients around the period of extubation that h...
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| Format: | Article |
| Language: | English |
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BMC
2010-08-01
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| Series: | Respiratory Research |
| Online Access: | http://respiratory-research.com/content/11/1/117 |
| _version_ | 1818394028242108416 |
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| author | Flynn Gordon Mandersloot Gerlinde Healy Marie Saville Mark McAuley Daniel F |
| author_facet | Flynn Gordon Mandersloot Gerlinde Healy Marie Saville Mark McAuley Daniel F |
| author_sort | Flynn Gordon |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Prolonged weaning from mechanical ventilation has a major impact on ICU bed occupancy and patient outcome, and has significant cost implications.</p> <p>There is evidence in patients around the period of extubation that helium-oxygen leads to a reduction in the work of breathing. Therefore breathing helium-oxygen during weaning may be a useful adjunct to facilitate weaning. We hypothesised that breathing helium-oxygen would reduce carbon dioxide production during the weaning phase of mechanical ventilation.</p> <p>Materials/patients and methods</p> <p>We performed a prospective randomised controlled single blinded cross-over trial on 19 adult intensive care patients without significant airways disease who fulfilled criteria for weaning with CPAP. Patients were randomised to helium-oxygen and air-oxygen delivered during a 2 hour period of CPAP ventilation. Carbon dioxide production (VCO<sub>2</sub>) was measured using a near patient main stream infrared carbon dioxide sensor and fixed orifice pneumotachograph.</p> <p>Results</p> <p>Compared to air-oxygen, helium-oxygen significantly decreased VCO<sub>2 </sub>production at the end of the 2 hour period of CPAP ventilation; there was a mean difference in CO<sub>2 </sub>production of 48.9 ml/min (95% CI 18.7-79.2 p = 0.003) between the groups. There were no significant differences in other respiratory and haemodynamic parameters.</p> <p>Conclusion</p> <p>This study shows that breathing a helium-oxygen mixture during weaning reduces carbon dioxide production. This physiological study supports the need for a clinical trial of helium-oxygen mixture during the weaning phase of mechanical ventilation with duration of weaning as the primary outcome.</p> <p>Trial registration</p> <p>ISRCTN56470948</p> |
| first_indexed | 2024-12-14T05:54:41Z |
| format | Article |
| id | doaj.art-ce9bad61ae484ea59a300afa9202484f |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-12-14T05:54:41Z |
| publishDate | 2010-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-ce9bad61ae484ea59a300afa9202484f2022-12-21T23:14:36ZengBMCRespiratory Research1465-99212010-08-0111111710.1186/1465-9921-11-117Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilationFlynn GordonMandersloot GerlindeHealy MarieSaville MarkMcAuley Daniel F<p>Abstract</p> <p>Background</p> <p>Prolonged weaning from mechanical ventilation has a major impact on ICU bed occupancy and patient outcome, and has significant cost implications.</p> <p>There is evidence in patients around the period of extubation that helium-oxygen leads to a reduction in the work of breathing. Therefore breathing helium-oxygen during weaning may be a useful adjunct to facilitate weaning. We hypothesised that breathing helium-oxygen would reduce carbon dioxide production during the weaning phase of mechanical ventilation.</p> <p>Materials/patients and methods</p> <p>We performed a prospective randomised controlled single blinded cross-over trial on 19 adult intensive care patients without significant airways disease who fulfilled criteria for weaning with CPAP. Patients were randomised to helium-oxygen and air-oxygen delivered during a 2 hour period of CPAP ventilation. Carbon dioxide production (VCO<sub>2</sub>) was measured using a near patient main stream infrared carbon dioxide sensor and fixed orifice pneumotachograph.</p> <p>Results</p> <p>Compared to air-oxygen, helium-oxygen significantly decreased VCO<sub>2 </sub>production at the end of the 2 hour period of CPAP ventilation; there was a mean difference in CO<sub>2 </sub>production of 48.9 ml/min (95% CI 18.7-79.2 p = 0.003) between the groups. There were no significant differences in other respiratory and haemodynamic parameters.</p> <p>Conclusion</p> <p>This study shows that breathing a helium-oxygen mixture during weaning reduces carbon dioxide production. This physiological study supports the need for a clinical trial of helium-oxygen mixture during the weaning phase of mechanical ventilation with duration of weaning as the primary outcome.</p> <p>Trial registration</p> <p>ISRCTN56470948</p>http://respiratory-research.com/content/11/1/117 |
| spellingShingle | Flynn Gordon Mandersloot Gerlinde Healy Marie Saville Mark McAuley Daniel F Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation Respiratory Research |
| title | Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation |
| title_full | Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation |
| title_fullStr | Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation |
| title_full_unstemmed | Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation |
| title_short | Helium-oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation |
| title_sort | helium oxygen reduces the production of carbon dioxide during weaning from mechanical ventilation |
| url | http://respiratory-research.com/content/11/1/117 |
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