Comparison of clinical outcomes of deceased donor kidney transplantations, with a focus on three induction therapies
Background : Graft survival rate of kidney transplantation recipients improves after induction therapy. However, there is no conclusive evidence on which regimen is superior for deceased donor kidney transplantation (DDKT). This study aims at discussing effective induction therapy in DDKT. Methods :...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society for Transplantation
2019-12-01
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| Series: | Korean Journal of Transplantation |
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| Online Access: | http://journaleditor.inforang.com/journal/view.html?doi=10.4285/jkstn.2019.33.4.118 |
| _version_ | 1797334890463625216 |
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| author | Eun Sung Jeong Kyo Won Lee Sang Jin Kim Hee Jin Yoo Kyung A Kim Jae Berm Park |
| author_facet | Eun Sung Jeong Kyo Won Lee Sang Jin Kim Hee Jin Yoo Kyung A Kim Jae Berm Park |
| author_sort | Eun Sung Jeong |
| collection | DOAJ |
| description | Background : Graft survival rate of kidney transplantation recipients improves after induction therapy. However, there is no conclusive evidence on which regimen is superior for deceased donor kidney transplantation (DDKT). This study aims at discussing effective induction therapy in DDKT. Methods : Between 2003 and 2016, 395 DDKT recipients were divided into three groups following induction therapy. Recipients of the basiliximab group (n=184) received basiliximab (20 mg/kg) on days 0 and 4. Recipients of the low-dose rabbit anti-thymocyte globulin (rATG) group (n=113) received rATG (1.5 mg/kg) on days 0, 1, and 2, while those of the high-dose rATG group (n=98) received it for more than 4 days. We retrospectively reviewed and analyzed the clinical outcomes and adverse effects of induction therapy.Results : Compared to other groups, the low-dose rATG group donors were older (P<0.001); rATG group donors had higher serum creatinine levels (P<0.001), and the basiliximab group showed a lower delayed graft function rate (P=0.004). In graft failure, the low-dose rATG group did not differ significantly from the basiliximab group (P=0.080), but was significantly different from the high-dose rATG group (P=0.004).Conclusion : s: The low-dose rATG group had the best graft survival rate, although it had older donors and higher serum creatinine levels. Therefore, low-dose rATG may be considered an effective induction therapy in DDKT. |
| first_indexed | 2024-03-08T08:27:46Z |
| format | Article |
| id | doaj.art-ce9e2c04980c456f9d84ce03a47384d3 |
| institution | Directory Open Access Journal |
| issn | 2671-8790 |
| language | English |
| last_indexed | 2024-03-08T08:27:46Z |
| publishDate | 2019-12-01 |
| publisher | Korean Society for Transplantation |
| record_format | Article |
| series | Korean Journal of Transplantation |
| spelling | doaj.art-ce9e2c04980c456f9d84ce03a47384d32024-02-02T04:20:13ZengKorean Society for TransplantationKorean Journal of Transplantation2671-87902019-12-0133411812710.4285/jkstn.2019.33.4.118jkstn.2019.33.4.118Comparison of clinical outcomes of deceased donor kidney transplantations, with a focus on three induction therapiesEun Sung Jeong0Kyo Won Lee1Sang Jin Kim2Hee Jin Yoo3Kyung A Kim4Jae Berm Park5Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaBiostatistics and Clinical Epidemiology Center, Samsung Medical Center, Seoul, KoreaBiostatistics and Clinical Epidemiology Center, Samsung Medical Center, Seoul, KoreaDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaBackground : Graft survival rate of kidney transplantation recipients improves after induction therapy. However, there is no conclusive evidence on which regimen is superior for deceased donor kidney transplantation (DDKT). This study aims at discussing effective induction therapy in DDKT. Methods : Between 2003 and 2016, 395 DDKT recipients were divided into three groups following induction therapy. Recipients of the basiliximab group (n=184) received basiliximab (20 mg/kg) on days 0 and 4. Recipients of the low-dose rabbit anti-thymocyte globulin (rATG) group (n=113) received rATG (1.5 mg/kg) on days 0, 1, and 2, while those of the high-dose rATG group (n=98) received it for more than 4 days. We retrospectively reviewed and analyzed the clinical outcomes and adverse effects of induction therapy.Results : Compared to other groups, the low-dose rATG group donors were older (P<0.001); rATG group donors had higher serum creatinine levels (P<0.001), and the basiliximab group showed a lower delayed graft function rate (P=0.004). In graft failure, the low-dose rATG group did not differ significantly from the basiliximab group (P=0.080), but was significantly different from the high-dose rATG group (P=0.004).Conclusion : s: The low-dose rATG group had the best graft survival rate, although it had older donors and higher serum creatinine levels. Therefore, low-dose rATG may be considered an effective induction therapy in DDKT.http://journaleditor.inforang.com/journal/view.html?doi=10.4285/jkstn.2019.33.4.118kidney transplantation; immunosuppressive agent; graft rejection |
| spellingShingle | Eun Sung Jeong Kyo Won Lee Sang Jin Kim Hee Jin Yoo Kyung A Kim Jae Berm Park Comparison of clinical outcomes of deceased donor kidney transplantations, with a focus on three induction therapies Korean Journal of Transplantation kidney transplantation; immunosuppressive agent; graft rejection |
| title | Comparison of clinical outcomes of deceased donor kidney transplantations, with a focus on three induction therapies |
| title_full | Comparison of clinical outcomes of deceased donor kidney transplantations, with a focus on three induction therapies |
| title_fullStr | Comparison of clinical outcomes of deceased donor kidney transplantations, with a focus on three induction therapies |
| title_full_unstemmed | Comparison of clinical outcomes of deceased donor kidney transplantations, with a focus on three induction therapies |
| title_short | Comparison of clinical outcomes of deceased donor kidney transplantations, with a focus on three induction therapies |
| title_sort | comparison of clinical outcomes of deceased donor kidney transplantations with a focus on three induction therapies |
| topic | kidney transplantation; immunosuppressive agent; graft rejection |
| url | http://journaleditor.inforang.com/journal/view.html?doi=10.4285/jkstn.2019.33.4.118 |
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