Effectiveness of Global Optimisation and Direct Kinematics in Predicting Surgical Outcome in Children with Cerebral Palsy
Multibody optimisation approaches have not seen much use in routine clinical applications despite evidence of improvements in modelling through a reduction in soft tissue artifacts compared to the standard gait analysis technique of direct kinematics. To inform clinical use, this study investigated...
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MDPI AG
2021-11-01
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| Online Access: | https://www.mdpi.com/2075-1729/11/12/1306 |
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| author | Claude Fiifi Hayford Emma Pratt John P. Cashman Owain G. Evans Claudia Mazzà |
| author_facet | Claude Fiifi Hayford Emma Pratt John P. Cashman Owain G. Evans Claudia Mazzà |
| author_sort | Claude Fiifi Hayford |
| collection | DOAJ |
| description | Multibody optimisation approaches have not seen much use in routine clinical applications despite evidence of improvements in modelling through a reduction in soft tissue artifacts compared to the standard gait analysis technique of direct kinematics. To inform clinical use, this study investigated the consistency with which both approaches predicted post-surgical outcomes, using changes in Gait Profile Score (GPS) when compared to a clinical assessment of outcome that did not include the 3D gait data. Retrospective three-dimensional motion capture data were utilised from 34 typically developing children and 26 children with cerebral palsy who underwent femoral derotation osteotomies as part of Single Event Multi-Level Surgeries. Results indicated that while, as expected, the GPS estimated from the two methods were numerically different, they were strongly correlated (Spearman’s ρ = 0.93), and no significant differences were observed between their estimations of change in GPS after surgery. The two scores equivalently classified a worsening or improvement in the gait quality in 93% of the cases. When compared with the clinical classification of responders versus non-responders to the intervention, an equivalent performance was found for the two approaches, with 27/41 and 28/41 cases in agreement with the clinical judgement for multibody optimisation and direct kinematics, respectively. With this equivalent performance to the direct kinematics approach and the benefit of being less sensitive to skin artefact and allowing additional analysis such as estimation of musculotendon lengths and joint contact forces, multibody optimisation has the potential to improve the clinical decision-making process in children with cerebral palsy. |
| first_indexed | 2024-03-10T03:44:17Z |
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| id | doaj.art-cea076b2014c445da63d1944a0c3dcec |
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| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T03:44:17Z |
| publishDate | 2021-11-01 |
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| spelling | doaj.art-cea076b2014c445da63d1944a0c3dcec2023-11-23T09:13:33ZengMDPI AGLife2075-17292021-11-011112130610.3390/life11121306Effectiveness of Global Optimisation and Direct Kinematics in Predicting Surgical Outcome in Children with Cerebral PalsyClaude Fiifi Hayford0Emma Pratt1John P. Cashman2Owain G. Evans3Claudia Mazzà4Department of Mechanical Engineering, INSIGNEO Institute for in Silico Medicine, University of Sheffield, Sheffield S10 2TN, UKGait Analysis Laboratory, Sheffield Children’s Hospital, Sheffield S10 5DP, UKGait Analysis Laboratory, Sheffield Children’s Hospital, Sheffield S10 5DP, UKGait Analysis Laboratory, Sheffield Children’s Hospital, Sheffield S10 5DP, UKDepartment of Mechanical Engineering, INSIGNEO Institute for in Silico Medicine, University of Sheffield, Sheffield S10 2TN, UKMultibody optimisation approaches have not seen much use in routine clinical applications despite evidence of improvements in modelling through a reduction in soft tissue artifacts compared to the standard gait analysis technique of direct kinematics. To inform clinical use, this study investigated the consistency with which both approaches predicted post-surgical outcomes, using changes in Gait Profile Score (GPS) when compared to a clinical assessment of outcome that did not include the 3D gait data. Retrospective three-dimensional motion capture data were utilised from 34 typically developing children and 26 children with cerebral palsy who underwent femoral derotation osteotomies as part of Single Event Multi-Level Surgeries. Results indicated that while, as expected, the GPS estimated from the two methods were numerically different, they were strongly correlated (Spearman’s ρ = 0.93), and no significant differences were observed between their estimations of change in GPS after surgery. The two scores equivalently classified a worsening or improvement in the gait quality in 93% of the cases. When compared with the clinical classification of responders versus non-responders to the intervention, an equivalent performance was found for the two approaches, with 27/41 and 28/41 cases in agreement with the clinical judgement for multibody optimisation and direct kinematics, respectively. With this equivalent performance to the direct kinematics approach and the benefit of being less sensitive to skin artefact and allowing additional analysis such as estimation of musculotendon lengths and joint contact forces, multibody optimisation has the potential to improve the clinical decision-making process in children with cerebral palsy.https://www.mdpi.com/2075-1729/11/12/1306gait analysisdirect kinematicsglobal optimisationgait profile scorecerebral palsy |
| spellingShingle | Claude Fiifi Hayford Emma Pratt John P. Cashman Owain G. Evans Claudia Mazzà Effectiveness of Global Optimisation and Direct Kinematics in Predicting Surgical Outcome in Children with Cerebral Palsy Life gait analysis direct kinematics global optimisation gait profile score cerebral palsy |
| title | Effectiveness of Global Optimisation and Direct Kinematics in Predicting Surgical Outcome in Children with Cerebral Palsy |
| title_full | Effectiveness of Global Optimisation and Direct Kinematics in Predicting Surgical Outcome in Children with Cerebral Palsy |
| title_fullStr | Effectiveness of Global Optimisation and Direct Kinematics in Predicting Surgical Outcome in Children with Cerebral Palsy |
| title_full_unstemmed | Effectiveness of Global Optimisation and Direct Kinematics in Predicting Surgical Outcome in Children with Cerebral Palsy |
| title_short | Effectiveness of Global Optimisation and Direct Kinematics in Predicting Surgical Outcome in Children with Cerebral Palsy |
| title_sort | effectiveness of global optimisation and direct kinematics in predicting surgical outcome in children with cerebral palsy |
| topic | gait analysis direct kinematics global optimisation gait profile score cerebral palsy |
| url | https://www.mdpi.com/2075-1729/11/12/1306 |
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