Drug-induced pulmonary artery hypertension
Pulmonary arterial hypertension is a condition characterized by an increase in mean pressure in the pulmonary artery. This pathology is associated with high mortality, and specific therapy for pulmonary arterial hypertension does not affect the cause of the disease and is extremely expensive. In thi...
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| Format: | Article |
| Language: | Russian |
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Izdatelstvo OKI
2022-05-01
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| Series: | Качественная клиническая практика |
| Subjects: | |
| Online Access: | https://www.clinvest.ru/jour/article/view/606 |
| _version_ | 1797262069478719488 |
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| author | O. D. Ostroumova A. I. Listratov A. I. Kochetkov S. A. Bliznyuk A. G. Komarova D. A. Sychev |
| author_facet | O. D. Ostroumova A. I. Listratov A. I. Kochetkov S. A. Bliznyuk A. G. Komarova D. A. Sychev |
| author_sort | O. D. Ostroumova |
| collection | DOAJ |
| description | Pulmonary arterial hypertension is a condition characterized by an increase in mean pressure in the pulmonary artery. This pathology is associated with high mortality, and specific therapy for pulmonary arterial hypertension does not affect the cause of the disease and is extremely expensive. In this regard, it is especially important to study the modifiable etiological factors of pulmonary arterial hypertension. One such factor is drugs. One of the leading groups of drugs-inductors is anorexigenic drugs. It was the representatives of this group, such as aminorex, who were the first inducers of pulmonary hypertension. Moreover, this adverse reaction was so significant that it led to the withdrawal of these drugs. Currently, the leading role in the context of drug-induced pulmonary hypertension is played by such drugs as anticancer, antiviral drugs, and interferons. These drugs lead to pulmonary hypertension through various pathophysiological mechanisms. The leading measures to prevent this pathology are to limit the use of culprit medications, reduce the spread of HIV infection, since several groups of drugs can be used to treat HIV-infected patients, leading to the development of pulmonary hypertension. |
| first_indexed | 2024-04-24T23:51:15Z |
| format | Article |
| id | doaj.art-cea1a84208a14d13aa733a06bbeb54a5 |
| institution | Directory Open Access Journal |
| issn | 2588-0519 2618-8473 |
| language | Russian |
| last_indexed | 2024-04-24T23:51:15Z |
| publishDate | 2022-05-01 |
| publisher | Izdatelstvo OKI |
| record_format | Article |
| series | Качественная клиническая практика |
| spelling | doaj.art-cea1a84208a14d13aa733a06bbeb54a52024-03-14T18:09:09ZrusIzdatelstvo OKIКачественная клиническая практика2588-05192618-84732022-05-0101536310.37489/2588-0519-2022-1-53-63587Drug-induced pulmonary artery hypertensionO. D. Ostroumova0A. I. Listratov1A. I. Kochetkov2S. A. Bliznyuk3A. G. Komarova4D. A. Sychev5ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» МЗ РФ; ФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава Российской Федерации (Сеченовский университет)ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» МЗ РФФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» МЗ РФГБУЗ ГКБ им. С. П. Боткина ДЗМГБУЗ ГКБ им. С. П. Боткина ДЗМФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» МЗ РФPulmonary arterial hypertension is a condition characterized by an increase in mean pressure in the pulmonary artery. This pathology is associated with high mortality, and specific therapy for pulmonary arterial hypertension does not affect the cause of the disease and is extremely expensive. In this regard, it is especially important to study the modifiable etiological factors of pulmonary arterial hypertension. One such factor is drugs. One of the leading groups of drugs-inductors is anorexigenic drugs. It was the representatives of this group, such as aminorex, who were the first inducers of pulmonary hypertension. Moreover, this adverse reaction was so significant that it led to the withdrawal of these drugs. Currently, the leading role in the context of drug-induced pulmonary hypertension is played by such drugs as anticancer, antiviral drugs, and interferons. These drugs lead to pulmonary hypertension through various pathophysiological mechanisms. The leading measures to prevent this pathology are to limit the use of culprit medications, reduce the spread of HIV infection, since several groups of drugs can be used to treat HIV-infected patients, leading to the development of pulmonary hypertension.https://www.clinvest.ru/jour/article/view/606лёгочная артериальная гипертензиялекарственно-индуцированная лёгочная артериальная гипертензиялекарственные средстванежелательные реакциипротивоопухолевые препараты |
| spellingShingle | O. D. Ostroumova A. I. Listratov A. I. Kochetkov S. A. Bliznyuk A. G. Komarova D. A. Sychev Drug-induced pulmonary artery hypertension Качественная клиническая практика лёгочная артериальная гипертензия лекарственно-индуцированная лёгочная артериальная гипертензия лекарственные средства нежелательные реакции противоопухолевые препараты |
| title | Drug-induced pulmonary artery hypertension |
| title_full | Drug-induced pulmonary artery hypertension |
| title_fullStr | Drug-induced pulmonary artery hypertension |
| title_full_unstemmed | Drug-induced pulmonary artery hypertension |
| title_short | Drug-induced pulmonary artery hypertension |
| title_sort | drug induced pulmonary artery hypertension |
| topic | лёгочная артериальная гипертензия лекарственно-индуцированная лёгочная артериальная гипертензия лекарственные средства нежелательные реакции противоопухолевые препараты |
| url | https://www.clinvest.ru/jour/article/view/606 |
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