Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification
Wenting Chen,1 Jinxi Liu,1 Caiyun Zheng,1 Que Bai,1 Qian Gao,1 Yanni Zhang,1 Kai Dong,2 Tingli Lu1 1Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2School of Pharmacy, Xi’an Jiaotong U...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-06-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/research-progress-on-improving-the-efficiency-of-cdt-by-exacerbating-t-peer-reviewed-fulltext-article-IJN |
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| author | Chen W Liu J Zheng C Bai Q Gao Q Zhang Y Dong K Lu T |
| author_facet | Chen W Liu J Zheng C Bai Q Gao Q Zhang Y Dong K Lu T |
| author_sort | Chen W |
| collection | DOAJ |
| description | Wenting Chen,1 Jinxi Liu,1 Caiyun Zheng,1 Que Bai,1 Qian Gao,1 Yanni Zhang,1 Kai Dong,2 Tingli Lu1 1Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of ChinaCorrespondence: Tingli Lu, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29 8846 0332, Email lutinglixinxin@nwpu.edu.cn Kai Dong, School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29-82655139, Email dongkai120@xjtu.edu.cnAbstract: In recent years, chemodynamic therapy (CDT) has received extensive attention as a novel means of cancer treatment. The CDT agents can exert Fenton and Fenton-like reactions in the acidic tumor microenvironment (TME), converting hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (·OH). However, the pH of TME, as an essential factor in the Fenton reaction, does not catalyze the reaction effectively, hindering its efficiency, which poses a significant challenge for the future clinical application of CDT. Therefore, this paper reviews various strategies to enhance the antitumor properties of nanomaterials by modulating tumor acidity. Ultimately, the performance of CDT can be further improved by inducing strong oxidative stress to produce sufficient ·OH. In this paper, the various acidification pathways and proton pumps with potential acidification functions are mainly discussed, such as catalytic enzymes, exogenous acids, CAIX, MCT, NHE, NBCn1, etc. The problems, opportunities, and challenges of CDT in the cancer field are also discussed, thereby providing new insights for the design of nanomaterials and laying the foundation for their future clinical applications.Graphical Abstract: Keywords: chemodynamic therapy, Fenton/Fenton-like reactions, tumor microenvironment, reactive oxygen specie |
| first_indexed | 2024-12-12T13:39:26Z |
| format | Article |
| id | doaj.art-cea1eb930cee4c8b8746abc33e47316f |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-12-12T13:39:26Z |
| publishDate | 2022-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-cea1eb930cee4c8b8746abc33e47316f2022-12-22T00:22:51ZengDove Medical PressInternational Journal of Nanomedicine1178-20132022-06-01Volume 172611262875867Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor AcidificationChen WLiu JZheng CBai QGao QZhang YDong KLu TWenting Chen,1 Jinxi Liu,1 Caiyun Zheng,1 Que Bai,1 Qian Gao,1 Yanni Zhang,1 Kai Dong,2 Tingli Lu1 1Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China; 2School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of ChinaCorrespondence: Tingli Lu, Key Laboratory for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29 8846 0332, Email lutinglixinxin@nwpu.edu.cn Kai Dong, School of Pharmacy, Xi’an Jiaotong University, Xi’an, 710072, People’s Republic of China, Tel/Fax +86 29-82655139, Email dongkai120@xjtu.edu.cnAbstract: In recent years, chemodynamic therapy (CDT) has received extensive attention as a novel means of cancer treatment. The CDT agents can exert Fenton and Fenton-like reactions in the acidic tumor microenvironment (TME), converting hydrogen peroxide (H2O2) into highly toxic hydroxyl radicals (·OH). However, the pH of TME, as an essential factor in the Fenton reaction, does not catalyze the reaction effectively, hindering its efficiency, which poses a significant challenge for the future clinical application of CDT. Therefore, this paper reviews various strategies to enhance the antitumor properties of nanomaterials by modulating tumor acidity. Ultimately, the performance of CDT can be further improved by inducing strong oxidative stress to produce sufficient ·OH. In this paper, the various acidification pathways and proton pumps with potential acidification functions are mainly discussed, such as catalytic enzymes, exogenous acids, CAIX, MCT, NHE, NBCn1, etc. The problems, opportunities, and challenges of CDT in the cancer field are also discussed, thereby providing new insights for the design of nanomaterials and laying the foundation for their future clinical applications.Graphical Abstract: Keywords: chemodynamic therapy, Fenton/Fenton-like reactions, tumor microenvironment, reactive oxygen speciehttps://www.dovepress.com/research-progress-on-improving-the-efficiency-of-cdt-by-exacerbating-t-peer-reviewed-fulltext-article-IJNchemodynamic therapyfenton/fenton-like reactionstumor microenvironmentreactive oxygen specie |
| spellingShingle | Chen W Liu J Zheng C Bai Q Gao Q Zhang Y Dong K Lu T Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification International Journal of Nanomedicine chemodynamic therapy fenton/fenton-like reactions tumor microenvironment reactive oxygen specie |
| title | Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification |
| title_full | Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification |
| title_fullStr | Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification |
| title_full_unstemmed | Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification |
| title_short | Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification |
| title_sort | research progress on improving the efficiency of cdt by exacerbating tumor acidification |
| topic | chemodynamic therapy fenton/fenton-like reactions tumor microenvironment reactive oxygen specie |
| url | https://www.dovepress.com/research-progress-on-improving-the-efficiency-of-cdt-by-exacerbating-t-peer-reviewed-fulltext-article-IJN |
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