Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids
Alkaloids are an important group of specialized nitrogen metabolites with a wide range of biochemical and pharmacological effects. Since the first publication on lycorine in 1877, more than 650 alkaloids have been extracted from Amaryllidaceae bulbous plants and clustered together as the Amaryllidac...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/21/4901 |
| _version_ | 1797550057071837184 |
|---|---|
| author | Seydou Ka Manoj Koirala Natacha Mérindol Isabel Desgagné-Penix |
| author_facet | Seydou Ka Manoj Koirala Natacha Mérindol Isabel Desgagné-Penix |
| author_sort | Seydou Ka |
| collection | DOAJ |
| description | Alkaloids are an important group of specialized nitrogen metabolites with a wide range of biochemical and pharmacological effects. Since the first publication on lycorine in 1877, more than 650 alkaloids have been extracted from Amaryllidaceae bulbous plants and clustered together as the Amaryllidaceae alkaloids (AAs) family. AAs are specifically remarkable for their diverse pharmaceutical properties, as exemplified by the success of galantamine used to treat the symptoms of Alzheimer’s disease. This review addresses the isolation, biological, and structure activity of AAs discovered from January 2015 to August 2020, supporting their therapeutic interest. |
| first_indexed | 2024-03-10T15:24:03Z |
| format | Article |
| id | doaj.art-cea30c0c5c6945a587b4c8c73d59ed39 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T15:24:03Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-cea30c0c5c6945a587b4c8c73d59ed392023-11-20T18:14:34ZengMDPI AGMolecules1420-30492020-10-012521490110.3390/molecules25214901Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae AlkaloidsSeydou Ka0Manoj Koirala1Natacha Mérindol2Isabel Desgagné-Penix3Department of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, 3351, boul. des Forges, C.P. 500, Trois-Rivières, QC G9A 5H7, CanadaDepartment of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, 3351, boul. des Forges, C.P. 500, Trois-Rivières, QC G9A 5H7, CanadaDepartment of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, 3351, boul. des Forges, C.P. 500, Trois-Rivières, QC G9A 5H7, CanadaDepartment of Chemistry, Biochemistry and Physics, Université du Québec à Trois-Rivières, 3351, boul. des Forges, C.P. 500, Trois-Rivières, QC G9A 5H7, CanadaAlkaloids are an important group of specialized nitrogen metabolites with a wide range of biochemical and pharmacological effects. Since the first publication on lycorine in 1877, more than 650 alkaloids have been extracted from Amaryllidaceae bulbous plants and clustered together as the Amaryllidaceae alkaloids (AAs) family. AAs are specifically remarkable for their diverse pharmaceutical properties, as exemplified by the success of galantamine used to treat the symptoms of Alzheimer’s disease. This review addresses the isolation, biological, and structure activity of AAs discovered from January 2015 to August 2020, supporting their therapeutic interest.https://www.mdpi.com/1420-3049/25/21/4901Amaryllidaceae alkaloidsspecialized metabolismbiosynthesisantitumoranti-cholinesteraseantiviral |
| spellingShingle | Seydou Ka Manoj Koirala Natacha Mérindol Isabel Desgagné-Penix Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids Molecules Amaryllidaceae alkaloids specialized metabolism biosynthesis antitumor anti-cholinesterase antiviral |
| title | Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids |
| title_full | Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids |
| title_fullStr | Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids |
| title_full_unstemmed | Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids |
| title_short | Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids |
| title_sort | biosynthesis and biological activities of newly discovered amaryllidaceae alkaloids |
| topic | Amaryllidaceae alkaloids specialized metabolism biosynthesis antitumor anti-cholinesterase antiviral |
| url | https://www.mdpi.com/1420-3049/25/21/4901 |
| work_keys_str_mv | AT seydouka biosynthesisandbiologicalactivitiesofnewlydiscoveredamaryllidaceaealkaloids AT manojkoirala biosynthesisandbiologicalactivitiesofnewlydiscoveredamaryllidaceaealkaloids AT natachamerindol biosynthesisandbiologicalactivitiesofnewlydiscoveredamaryllidaceaealkaloids AT isabeldesgagnepenix biosynthesisandbiologicalactivitiesofnewlydiscoveredamaryllidaceaealkaloids |