Serum uric acid level is correlated with the clinical, pathological progression and prognosis of IgA nephropathy: an observational retrospective pilot-study
Objectives This study was aimed to assess the relationship between serum uric acid (SUA) level and the clinical, pathological phenotype of IgA nephropathy (IgAN), and to determine the role of SUA level in the progression and prognosis of IgAN. Methods A total of 208 patients with IgAN were included...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PeerJ Inc.
2020-11-01
|
| Series: | PeerJ |
| Subjects: | |
| Online Access: | https://peerj.com/articles/10130.pdf |
| _version_ | 1797419729875369984 |
|---|---|
| author | Pingfan Lu Xiaoqing Li Na Zhu Yuanjun Deng Yang Cai Tianjing Zhang Lele Liu Xueping Lin Yiyan Guo Min Han |
| author_facet | Pingfan Lu Xiaoqing Li Na Zhu Yuanjun Deng Yang Cai Tianjing Zhang Lele Liu Xueping Lin Yiyan Guo Min Han |
| author_sort | Pingfan Lu |
| collection | DOAJ |
| description | Objectives This study was aimed to assess the relationship between serum uric acid (SUA) level and the clinical, pathological phenotype of IgA nephropathy (IgAN), and to determine the role of SUA level in the progression and prognosis of IgAN. Methods A total of 208 patients with IgAN were included in this study, and were classified into the normo-uricemia group and hyperuricemia group according to the SUA level. The clinical data at baseline, IgAN Oxford classification scores (MEST-C scoring system), and other pathological features were collected and further analyzed. All patients were followed up and the prognosis was assessed using Kaplan-Meier survival curves. GraphPad Prism 7.0 and SPSS 23.0 were used for statistical analyses. Results In clinical indicators, patients with hyperuricemia had the significantly higher proportion of males to females, mean arterial pressure, the levels of total cholesterol, triglyceride, Scr, BUN, 24 hour-urine protein, C3, and C4, the lower levels of high-density lipoprotein cholesterol and eGFR than those without (p < 0.05). In terms of pathological characteristics, the tubular atrophy/interstitial fibrosis scores, vascular injury scores, and glomerular sclerosis percentage were significantly higher in patients with hyperuricemia compared with those without (p < 0.01). There was no significant difference in the scores of mesangial hypercellularity, endocapillary hypercellularity, focal segmental glomerulosclerosis, as well as crescents between the two groups (p > 0.05). As for the depositions of immune complexes deposition in IgAN, the hyperuricemia group had less deposition of immunoglobulin G and FRA than the normo-uricemia group (p < 0.05), while the deposition of immunoglobulin A, immunoglobulin M, and complement C3 in the two groups showed no statistical difference. The survival curve suggested that patients in the hyperuricemia group have significantly poorer renal outcome than those in the normo-uricemia group (p = 0.0147). Results also revealed that the SUA level is a valuable predictor of renal outcome in patients with IgAN. The optimal cutoff value was 361.1 µmol/L (AUC = 0.76 ± 0.08167) and 614 µmol/L (AUC = 0.5728 ± 0.2029) for female and male, respectively. Conclusions The level of SUA is associated with renal function level and pathological severity of IgAN, and maybe a prognostic indicator of IgAN. |
| first_indexed | 2024-03-09T06:52:33Z |
| format | Article |
| id | doaj.art-cea3859b05e24d4f9211960ffb78c557 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:52:33Z |
| publishDate | 2020-11-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-cea3859b05e24d4f9211960ffb78c5572023-12-03T10:24:39ZengPeerJ Inc.PeerJ2167-83592020-11-018e1013010.7717/peerj.10130Serum uric acid level is correlated with the clinical, pathological progression and prognosis of IgA nephropathy: an observational retrospective pilot-studyPingfan Lu0Xiaoqing Li1Na Zhu2Yuanjun Deng3Yang Cai4Tianjing Zhang5Lele Liu6Xueping Lin7Yiyan Guo8Min Han9Division of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDivision of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaObjectives This study was aimed to assess the relationship between serum uric acid (SUA) level and the clinical, pathological phenotype of IgA nephropathy (IgAN), and to determine the role of SUA level in the progression and prognosis of IgAN. Methods A total of 208 patients with IgAN were included in this study, and were classified into the normo-uricemia group and hyperuricemia group according to the SUA level. The clinical data at baseline, IgAN Oxford classification scores (MEST-C scoring system), and other pathological features were collected and further analyzed. All patients were followed up and the prognosis was assessed using Kaplan-Meier survival curves. GraphPad Prism 7.0 and SPSS 23.0 were used for statistical analyses. Results In clinical indicators, patients with hyperuricemia had the significantly higher proportion of males to females, mean arterial pressure, the levels of total cholesterol, triglyceride, Scr, BUN, 24 hour-urine protein, C3, and C4, the lower levels of high-density lipoprotein cholesterol and eGFR than those without (p < 0.05). In terms of pathological characteristics, the tubular atrophy/interstitial fibrosis scores, vascular injury scores, and glomerular sclerosis percentage were significantly higher in patients with hyperuricemia compared with those without (p < 0.01). There was no significant difference in the scores of mesangial hypercellularity, endocapillary hypercellularity, focal segmental glomerulosclerosis, as well as crescents between the two groups (p > 0.05). As for the depositions of immune complexes deposition in IgAN, the hyperuricemia group had less deposition of immunoglobulin G and FRA than the normo-uricemia group (p < 0.05), while the deposition of immunoglobulin A, immunoglobulin M, and complement C3 in the two groups showed no statistical difference. The survival curve suggested that patients in the hyperuricemia group have significantly poorer renal outcome than those in the normo-uricemia group (p = 0.0147). Results also revealed that the SUA level is a valuable predictor of renal outcome in patients with IgAN. The optimal cutoff value was 361.1 µmol/L (AUC = 0.76 ± 0.08167) and 614 µmol/L (AUC = 0.5728 ± 0.2029) for female and male, respectively. Conclusions The level of SUA is associated with renal function level and pathological severity of IgAN, and maybe a prognostic indicator of IgAN.https://peerj.com/articles/10130.pdfSerum uric acidPathological progressionPrognosisIgA nephropathy |
| spellingShingle | Pingfan Lu Xiaoqing Li Na Zhu Yuanjun Deng Yang Cai Tianjing Zhang Lele Liu Xueping Lin Yiyan Guo Min Han Serum uric acid level is correlated with the clinical, pathological progression and prognosis of IgA nephropathy: an observational retrospective pilot-study PeerJ Serum uric acid Pathological progression Prognosis IgA nephropathy |
| title | Serum uric acid level is correlated with the clinical, pathological progression and prognosis of IgA nephropathy: an observational retrospective pilot-study |
| title_full | Serum uric acid level is correlated with the clinical, pathological progression and prognosis of IgA nephropathy: an observational retrospective pilot-study |
| title_fullStr | Serum uric acid level is correlated with the clinical, pathological progression and prognosis of IgA nephropathy: an observational retrospective pilot-study |
| title_full_unstemmed | Serum uric acid level is correlated with the clinical, pathological progression and prognosis of IgA nephropathy: an observational retrospective pilot-study |
| title_short | Serum uric acid level is correlated with the clinical, pathological progression and prognosis of IgA nephropathy: an observational retrospective pilot-study |
| title_sort | serum uric acid level is correlated with the clinical pathological progression and prognosis of iga nephropathy an observational retrospective pilot study |
| topic | Serum uric acid Pathological progression Prognosis IgA nephropathy |
| url | https://peerj.com/articles/10130.pdf |
| work_keys_str_mv | AT pingfanlu serumuricacidleveliscorrelatedwiththeclinicalpathologicalprogressionandprognosisofiganephropathyanobservationalretrospectivepilotstudy AT xiaoqingli serumuricacidleveliscorrelatedwiththeclinicalpathologicalprogressionandprognosisofiganephropathyanobservationalretrospectivepilotstudy AT nazhu serumuricacidleveliscorrelatedwiththeclinicalpathologicalprogressionandprognosisofiganephropathyanobservationalretrospectivepilotstudy AT yuanjundeng serumuricacidleveliscorrelatedwiththeclinicalpathologicalprogressionandprognosisofiganephropathyanobservationalretrospectivepilotstudy AT yangcai serumuricacidleveliscorrelatedwiththeclinicalpathologicalprogressionandprognosisofiganephropathyanobservationalretrospectivepilotstudy AT tianjingzhang serumuricacidleveliscorrelatedwiththeclinicalpathologicalprogressionandprognosisofiganephropathyanobservationalretrospectivepilotstudy AT leleliu serumuricacidleveliscorrelatedwiththeclinicalpathologicalprogressionandprognosisofiganephropathyanobservationalretrospectivepilotstudy AT xuepinglin serumuricacidleveliscorrelatedwiththeclinicalpathologicalprogressionandprognosisofiganephropathyanobservationalretrospectivepilotstudy AT yiyanguo serumuricacidleveliscorrelatedwiththeclinicalpathologicalprogressionandprognosisofiganephropathyanobservationalretrospectivepilotstudy AT minhan serumuricacidleveliscorrelatedwiththeclinicalpathologicalprogressionandprognosisofiganephropathyanobservationalretrospectivepilotstudy |