Dynamical Task Switching in Cellular Computers

We present a scheme for implementing a version of task switching in engineered bacteria, based on the manipulation of plasmid copy numbers. Our method allows for the embedding of multiple computations in a cellular population, whilst minimising resource usage inefficiency. We describe the results of...

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Main Authors: Angel Goñi-Moreno, Fernando de la Cruz, Alfonso Rodríguez-Patón, Martyn Amos
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Life
Subjects:
Online Access:https://www.mdpi.com/2075-1729/9/1/14
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author Angel Goñi-Moreno
Fernando de la Cruz
Alfonso Rodríguez-Patón
Martyn Amos
author_facet Angel Goñi-Moreno
Fernando de la Cruz
Alfonso Rodríguez-Patón
Martyn Amos
author_sort Angel Goñi-Moreno
collection DOAJ
description We present a scheme for implementing a version of task switching in engineered bacteria, based on the manipulation of plasmid copy numbers. Our method allows for the embedding of multiple computations in a cellular population, whilst minimising resource usage inefficiency. We describe the results of computational simulations of our model, and discuss the potential for future work in this area.
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spelling doaj.art-cea44e24acc54287aa544ca3317b7da62022-12-22T02:56:56ZengMDPI AGLife2075-17292019-01-01911410.3390/life9010014life9010014Dynamical Task Switching in Cellular ComputersAngel Goñi-Moreno0Fernando de la Cruz1Alfonso Rodríguez-Patón2Martyn Amos3School of Computing, Newcastle University, Newcastle Upon Tyne NE4 5TG, UKInstituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria, 39011 Santander, SpainDepartamento de Inteligencia Artificial, Universidad Politécnica de Madrid, 28660 Madrid, SpainDepartment of Computer and Information Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UKWe present a scheme for implementing a version of task switching in engineered bacteria, based on the manipulation of plasmid copy numbers. Our method allows for the embedding of multiple computations in a cellular population, whilst minimising resource usage inefficiency. We describe the results of computational simulations of our model, and discuss the potential for future work in this area.https://www.mdpi.com/2075-1729/9/1/14synthetic biologycellular computingplasmids
spellingShingle Angel Goñi-Moreno
Fernando de la Cruz
Alfonso Rodríguez-Patón
Martyn Amos
Dynamical Task Switching in Cellular Computers
Life
synthetic biology
cellular computing
plasmids
title Dynamical Task Switching in Cellular Computers
title_full Dynamical Task Switching in Cellular Computers
title_fullStr Dynamical Task Switching in Cellular Computers
title_full_unstemmed Dynamical Task Switching in Cellular Computers
title_short Dynamical Task Switching in Cellular Computers
title_sort dynamical task switching in cellular computers
topic synthetic biology
cellular computing
plasmids
url https://www.mdpi.com/2075-1729/9/1/14
work_keys_str_mv AT angelgonimoreno dynamicaltaskswitchingincellularcomputers
AT fernandodelacruz dynamicaltaskswitchingincellularcomputers
AT alfonsorodriguezpaton dynamicaltaskswitchingincellularcomputers
AT martynamos dynamicaltaskswitchingincellularcomputers