Efek Imunomodulator Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) terhadap Tikus Putih (Rattus norvegicus) Jantan dengan Parameter Delayed Type Hypersensitivity (DTH)
Portulaca oleracea L. is one of the plants empirically used as medicine and contains flavonoid compounds assumed to have an immunomodulatory effect. The research aimed to determine the immunomodulatory effect of ethanol extract of Portulaca oleracea L by Delayed Type Hypersensitivity parameter. The...
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| Format: | Article |
| Language: | English |
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Universitas Tadulako
2020-03-01
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| Series: | Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) |
| Subjects: | |
| Online Access: | https://bestjournal.untad.ac.id/index.php/Galenika/article/view/14106 |
| _version_ | 1818312129554415616 |
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| author | Bayu Putra Rizqi Nur Azizah Eka Maryam Nopriyanti |
| author_facet | Bayu Putra Rizqi Nur Azizah Eka Maryam Nopriyanti |
| author_sort | Bayu Putra |
| collection | DOAJ |
| description | Portulaca oleracea L. is one of the plants empirically used as medicine and contains flavonoid compounds assumed to have an immunomodulatory effect. The research aimed to determine the immunomodulatory effect of ethanol extract of Portulaca oleracea L by Delayed Type Hypersensitivity parameter. The research used 20 male rats (Rattus norvegicus) divided into 5 groups where each group consisted of 4. Group I as a normal group (without treatment), group II (NaCMC control), group III, IV and V (treatment groups) were given EEHK with doses of 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW doses. The dosage form was orally given for 7 days. On day 3, the rats were induced with SDMD antigen 10% v/v by intraperitonial and intraplantar on day 7. The observations were conducted by measuring the volume change of the rat's feet at the 4th, 24th, and 48th hours using a pletismometer. The research data obtained were statistically processed using Paired Samples T Test, One-Way Anova and Post Hoc LSD tests. The results of the research showed that the ethanol extract of common purslane was effective as an immunomodulator. |
| first_indexed | 2024-12-13T08:12:57Z |
| format | Article |
| id | doaj.art-cea5a23736024394a74540ed3092fd7b |
| institution | Directory Open Access Journal |
| issn | 2442-7284 2442-8744 |
| language | English |
| last_indexed | 2024-12-13T08:12:57Z |
| publishDate | 2020-03-01 |
| publisher | Universitas Tadulako |
| record_format | Article |
| series | Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) |
| spelling | doaj.art-cea5a23736024394a74540ed3092fd7b2022-12-21T23:54:11ZengUniversitas TadulakoJurnal Farmasi Galenika (Galenika Journal of Pharmacy)2442-72842442-87442020-03-0161202510.22487/j24428744.2020.v6.i1.1410614106Efek Imunomodulator Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) terhadap Tikus Putih (Rattus norvegicus) Jantan dengan Parameter Delayed Type Hypersensitivity (DTH)Bayu Putra0Rizqi Nur Azizah1Eka Maryam Nopriyanti2Fakultas Farmasi, Universitas Muslim Indonesia, MakassarFakultas Farmasi, Universitas Muslim Indonesia, MakassarFakultas Farmasi, Universitas Muslim Indonesia, MakassarPortulaca oleracea L. is one of the plants empirically used as medicine and contains flavonoid compounds assumed to have an immunomodulatory effect. The research aimed to determine the immunomodulatory effect of ethanol extract of Portulaca oleracea L by Delayed Type Hypersensitivity parameter. The research used 20 male rats (Rattus norvegicus) divided into 5 groups where each group consisted of 4. Group I as a normal group (without treatment), group II (NaCMC control), group III, IV and V (treatment groups) were given EEHK with doses of 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW doses. The dosage form was orally given for 7 days. On day 3, the rats were induced with SDMD antigen 10% v/v by intraperitonial and intraplantar on day 7. The observations were conducted by measuring the volume change of the rat's feet at the 4th, 24th, and 48th hours using a pletismometer. The research data obtained were statistically processed using Paired Samples T Test, One-Way Anova and Post Hoc LSD tests. The results of the research showed that the ethanol extract of common purslane was effective as an immunomodulator.https://bestjournal.untad.ac.id/index.php/Galenika/article/view/14106portulaca oleracea l.immunomodulatorsdelayed type hypersensitivity (dth) |
| spellingShingle | Bayu Putra Rizqi Nur Azizah Eka Maryam Nopriyanti Efek Imunomodulator Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) terhadap Tikus Putih (Rattus norvegicus) Jantan dengan Parameter Delayed Type Hypersensitivity (DTH) Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) portulaca oleracea l. immunomodulators delayed type hypersensitivity (dth) |
| title | Efek Imunomodulator Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) terhadap Tikus Putih (Rattus norvegicus) Jantan dengan Parameter Delayed Type Hypersensitivity (DTH) |
| title_full | Efek Imunomodulator Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) terhadap Tikus Putih (Rattus norvegicus) Jantan dengan Parameter Delayed Type Hypersensitivity (DTH) |
| title_fullStr | Efek Imunomodulator Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) terhadap Tikus Putih (Rattus norvegicus) Jantan dengan Parameter Delayed Type Hypersensitivity (DTH) |
| title_full_unstemmed | Efek Imunomodulator Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) terhadap Tikus Putih (Rattus norvegicus) Jantan dengan Parameter Delayed Type Hypersensitivity (DTH) |
| title_short | Efek Imunomodulator Ekstrak Etanol Herba Krokot (Portulaca oleracea L.) terhadap Tikus Putih (Rattus norvegicus) Jantan dengan Parameter Delayed Type Hypersensitivity (DTH) |
| title_sort | efek imunomodulator ekstrak etanol herba krokot portulaca oleracea l terhadap tikus putih rattus norvegicus jantan dengan parameter delayed type hypersensitivity dth |
| topic | portulaca oleracea l. immunomodulators delayed type hypersensitivity (dth) |
| url | https://bestjournal.untad.ac.id/index.php/Galenika/article/view/14106 |
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