Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications
The buriti oil (<i>Mauritia flexuosa</i> L.) can be associated with polymeric matrices for biomedical applications. This study aimed to evaluate the effect of chitosan gel (CG) associated with buriti oil (CGB) as a healing agent. The fatty acids and volatile compounds composition of buri...
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| Format: | Article |
| Language: | English |
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2020-04-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/13/8/1977 |
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| author | Maria Onaira Gonçalves Ferreira Idglan Sá Lima Alessandra Braga Ribeiro Anderson O. Lobo Marcia S. Rizzo Josy Anteveli Osajima Leticia Miranda Estevinho Edson C. Silva-Filho |
| author_facet | Maria Onaira Gonçalves Ferreira Idglan Sá Lima Alessandra Braga Ribeiro Anderson O. Lobo Marcia S. Rizzo Josy Anteveli Osajima Leticia Miranda Estevinho Edson C. Silva-Filho |
| author_sort | Maria Onaira Gonçalves Ferreira |
| collection | DOAJ |
| description | The buriti oil (<i>Mauritia flexuosa</i> L.) can be associated with polymeric matrices for biomedical applications. This study aimed to evaluate the effect of chitosan gel (CG) associated with buriti oil (CGB) as a healing agent. The fatty acids and volatile compounds composition of buriti oil were performed and the composite gels were characterized using FTIR and thermal analysis. Biological tests including antimicrobial, antioxidant, anti-inflammatory and healing effects were also investigated. Buriti oil is composed of oleic and palmitic acids, and the main volatile compounds were identified. The buriti oil did not show antimicrobial activity, on the other hand, the composite gel (chitosan and oil) proved to be efficient against <i>Staphylococcus aureus</i> and <i>Klebsiella pneumonia</i> at the 10 mg/mL. Similar behavior was observed for antioxidant activity, determined by the β-carotene bleaching assay, composite gels presenting higher activity and buriti oil showed anti-inflammatory activity, which may be related to the inhibition of the release of free radicals. Regarding wound healing performed using in vivo testing, the composite gel (CGB) was found to promote faster and complete wound retraction. The results indicated that the gel chitosan–buriti oil has a set of properties that improve its antibacterial, antioxidant and healing action, suggesting that this material can be used to treat skin lesions. |
| first_indexed | 2024-03-10T20:16:46Z |
| format | Article |
| id | doaj.art-cea8b34721ba41b1894dfae709087e2c |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T20:16:46Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-cea8b34721ba41b1894dfae709087e2c2023-11-19T22:32:36ZengMDPI AGMaterials1996-19442020-04-01138197710.3390/ma13081977Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing ApplicationsMaria Onaira Gonçalves Ferreira0Idglan Sá Lima1Alessandra Braga Ribeiro2Anderson O. Lobo3Marcia S. Rizzo4Josy Anteveli Osajima5Leticia Miranda Estevinho6Edson C. Silva-Filho7Materials Science and Engineering Graduate Program, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, Teresina, PI CEP 64049-550, BrazilMaterials Science and Engineering Graduate Program, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, Teresina, PI CEP 64049-550, BrazilFaculty of Biotechnology, CBQF–Centre of Biotechnology and Fine Chemistry–Associate Laboratory, Catholic University of Portugal, Rua Diogo Botelho 1327, 4169-005 Porto, PortugalMaterials Science and Engineering Graduate Program, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, Teresina, PI CEP 64049-550, BrazilMaterials Science and Engineering Graduate Program, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, Teresina, PI CEP 64049-550, BrazilMaterials Science and Engineering Graduate Program, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, Teresina, PI CEP 64049-550, BrazilPolytechnic Institute of Bragança, Agricultural College of Bragança, Campus Santa Apolónia, 5301-855 Bragança, PortugalMaterials Science and Engineering Graduate Program, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, Teresina, PI CEP 64049-550, BrazilThe buriti oil (<i>Mauritia flexuosa</i> L.) can be associated with polymeric matrices for biomedical applications. This study aimed to evaluate the effect of chitosan gel (CG) associated with buriti oil (CGB) as a healing agent. The fatty acids and volatile compounds composition of buriti oil were performed and the composite gels were characterized using FTIR and thermal analysis. Biological tests including antimicrobial, antioxidant, anti-inflammatory and healing effects were also investigated. Buriti oil is composed of oleic and palmitic acids, and the main volatile compounds were identified. The buriti oil did not show antimicrobial activity, on the other hand, the composite gel (chitosan and oil) proved to be efficient against <i>Staphylococcus aureus</i> and <i>Klebsiella pneumonia</i> at the 10 mg/mL. Similar behavior was observed for antioxidant activity, determined by the β-carotene bleaching assay, composite gels presenting higher activity and buriti oil showed anti-inflammatory activity, which may be related to the inhibition of the release of free radicals. Regarding wound healing performed using in vivo testing, the composite gel (CGB) was found to promote faster and complete wound retraction. The results indicated that the gel chitosan–buriti oil has a set of properties that improve its antibacterial, antioxidant and healing action, suggesting that this material can be used to treat skin lesions.https://www.mdpi.com/1996-1944/13/8/1977polysaccharidesbiologicalhealing |
| spellingShingle | Maria Onaira Gonçalves Ferreira Idglan Sá Lima Alessandra Braga Ribeiro Anderson O. Lobo Marcia S. Rizzo Josy Anteveli Osajima Leticia Miranda Estevinho Edson C. Silva-Filho Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications Materials polysaccharides biological healing |
| title | Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications |
| title_full | Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications |
| title_fullStr | Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications |
| title_full_unstemmed | Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications |
| title_short | Biocompatible Gels of Chitosan–Buriti Oil for Potential Wound Healing Applications |
| title_sort | biocompatible gels of chitosan buriti oil for potential wound healing applications |
| topic | polysaccharides biological healing |
| url | https://www.mdpi.com/1996-1944/13/8/1977 |
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