High content screening and proteomic analysis identify a kinase inhibitor that rescues pathological phenotypes in a patient-derived model of Parkinson’s disease

High content screening and proteomic analysis identify a kinase inhibitor that rescues pathological phenotypes in a patient-derived model of Parkinson’s disease

Abstract Combining high throughput screening approaches with induced pluripotent stem cell (iPSC)-based disease modeling represents a promising unbiased strategy to identify therapies for neurodegenerative disorders. Here we applied high content imaging on iPSC-derived neurons from patients with fam...

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Bibliographic Details
Main Authors: Nasia Antoniou, Kanella Prodromidou, Georgia Kouroupi, Ioanna Boumpoureka, Martina Samiotaki, George Panayotou, Maria Xilouri, Ismini Kloukina, Leonidas Stefanis, Regis Grailhe, Era Taoufik, Rebecca Matsas
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-022-00278-y

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