Relationships between Vascular Leakage Factor and Pulmonary Dysfunction in Dengue Hemorrhagic Fever
Background: Mortality in Dengue patients hospitalized in Dr. Kariadi Hospital, Semarang is very high. The most common cause of death were bleeding and Multiple Organ Dysfunction including pulmonary dysfunction that manifest as Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). T...
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| Format: | Article |
| Language: | English |
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Universitas Sultan Agung Semarang
2011-06-01
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| Series: | Sains Medika |
| Subjects: | |
| Online Access: | http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/403 |
| _version_ | 1818362375219183616 |
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| author | Azizah Retno Kustiyah Soemantri AG Soemantri AG |
| author_facet | Azizah Retno Kustiyah Soemantri AG Soemantri AG |
| author_sort | Azizah Retno Kustiyah |
| collection | DOAJ |
| description | Background: Mortality in Dengue patients hospitalized in Dr. Kariadi Hospital, Semarang is very high. The most common cause of death were bleeding and Multiple Organ Dysfunction including pulmonary dysfunction that manifest as Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). The previous study have shown the incidence of ARDS in DSS but the incidence of pulmonary dysfunction in dengue hemorrhagic fever is unknown.
Design and Methods: An analytical observational study was performed in Non DSS and DSS patients. Researsh subjects were patients, aged 3-14 years old, with DHF according to WHO criteria 1999 hospitalized in the pediatric ward and Pediatric Intensive Care Unit (PICU) Dr. Kariadi Hospital Semarang from February 2003 until August 2005.
Result: Forty patients were included for analysis consisting of 20 Non DSS and 20 DSS. Mann-Whitney analysis showed a significant differences in the incidence pulmonary dysfunction between Non DSS and DSS patient (p < 0,05). Kendall’s Tau_b analysis showed a relationship between PEI value and pulmonary dysfunction, the low total protein plasma level with pulmonary dysfunction and the low albumin plasma level with pulmonary dysfunction with r = 0.552; 0.540; 0.353 respectively, (p= 0.01).
Conclusion: The study showed that pulmonary dysfunction occured more frequent in DSS than Non DSS. There were relationships between vascular leakage factors (PEI, total protein level, albumin level) with incidence of pulmonary dysfunction in DHF patients (Sains Medika, 3(1):1-15). |
| first_indexed | 2024-12-13T21:31:35Z |
| format | Article |
| id | doaj.art-cea96c77c3e745db8d55b3afcf818fd7 |
| institution | Directory Open Access Journal |
| issn | 2085-1545 2339-093X |
| language | English |
| last_indexed | 2024-12-13T21:31:35Z |
| publishDate | 2011-06-01 |
| publisher | Universitas Sultan Agung Semarang |
| record_format | Article |
| series | Sains Medika |
| spelling | doaj.art-cea96c77c3e745db8d55b3afcf818fd72022-12-21T23:30:49ZengUniversitas Sultan Agung SemarangSains Medika2085-15452339-093X2011-06-013111510.26532/sainsmed.v3i1.403399Relationships between Vascular Leakage Factor and Pulmonary Dysfunction in Dengue Hemorrhagic FeverAzizah Retno Kustiyah0Soemantri AG Soemantri AG1Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA)Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Diponegoro (UNDIP)Background: Mortality in Dengue patients hospitalized in Dr. Kariadi Hospital, Semarang is very high. The most common cause of death were bleeding and Multiple Organ Dysfunction including pulmonary dysfunction that manifest as Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS). The previous study have shown the incidence of ARDS in DSS but the incidence of pulmonary dysfunction in dengue hemorrhagic fever is unknown. Design and Methods: An analytical observational study was performed in Non DSS and DSS patients. Researsh subjects were patients, aged 3-14 years old, with DHF according to WHO criteria 1999 hospitalized in the pediatric ward and Pediatric Intensive Care Unit (PICU) Dr. Kariadi Hospital Semarang from February 2003 until August 2005. Result: Forty patients were included for analysis consisting of 20 Non DSS and 20 DSS. Mann-Whitney analysis showed a significant differences in the incidence pulmonary dysfunction between Non DSS and DSS patient (p < 0,05). Kendall’s Tau_b analysis showed a relationship between PEI value and pulmonary dysfunction, the low total protein plasma level with pulmonary dysfunction and the low albumin plasma level with pulmonary dysfunction with r = 0.552; 0.540; 0.353 respectively, (p= 0.01). Conclusion: The study showed that pulmonary dysfunction occured more frequent in DSS than Non DSS. There were relationships between vascular leakage factors (PEI, total protein level, albumin level) with incidence of pulmonary dysfunction in DHF patients (Sains Medika, 3(1):1-15).http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/403dengue hemorrhagic feverdengue shock syndromepulmonary dysfunction |
| spellingShingle | Azizah Retno Kustiyah Soemantri AG Soemantri AG Relationships between Vascular Leakage Factor and Pulmonary Dysfunction in Dengue Hemorrhagic Fever Sains Medika dengue hemorrhagic fever dengue shock syndrome pulmonary dysfunction |
| title | Relationships between Vascular Leakage Factor and Pulmonary Dysfunction in Dengue Hemorrhagic Fever |
| title_full | Relationships between Vascular Leakage Factor and Pulmonary Dysfunction in Dengue Hemorrhagic Fever |
| title_fullStr | Relationships between Vascular Leakage Factor and Pulmonary Dysfunction in Dengue Hemorrhagic Fever |
| title_full_unstemmed | Relationships between Vascular Leakage Factor and Pulmonary Dysfunction in Dengue Hemorrhagic Fever |
| title_short | Relationships between Vascular Leakage Factor and Pulmonary Dysfunction in Dengue Hemorrhagic Fever |
| title_sort | relationships between vascular leakage factor and pulmonary dysfunction in dengue hemorrhagic fever |
| topic | dengue hemorrhagic fever dengue shock syndrome pulmonary dysfunction |
| url | http://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/403 |
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