Antinociceptive effects of the combined use of butorphanol and buprenorphine in mice
Abstract Butorphanol and buprenorphine are mixed opioid receptor agonist‐antagonist drugs widely used as analgesics in people and animals. There are few reports concerning the interaction of multiple opioids, and their antinociceptive effects, when combined with other opioids, remain unclear. Theref...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-12-01
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| Series: | Neuropsychopharmacology Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/npr2.12202 |
| _version_ | 1811205915520532480 |
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| author | Kazumasu Sasaki Tatsuya Ishikawa Kazutaka Ikeda Shinya Kasai |
| author_facet | Kazumasu Sasaki Tatsuya Ishikawa Kazutaka Ikeda Shinya Kasai |
| author_sort | Kazumasu Sasaki |
| collection | DOAJ |
| description | Abstract Butorphanol and buprenorphine are mixed opioid receptor agonist‐antagonist drugs widely used as analgesics in people and animals. There are few reports concerning the interaction of multiple opioids, and their antinociceptive effects, when combined with other opioids, remain unclear. Therefore, we report the preliminary findings of the antinociceptive effects of the combined use of butorphanol and buprenorphine in C57BL/6JJcl mice. Both drugs were administered either simultaneously or in different orders. Compared with the baseline values, the tail‐flick and hot‐plate test latencies increased regardless of the order of administration. Furthermore, enhanced latencies were observed on administration of butorphanol followed by buprenorphine. Combined use of these drugs may not attenuate analgesic efficacy. Besides, enhancement of these effects can be obtained by changing the order of the administration of these drugs. It is necessary to further investigate the molecular basis of the underlying mechanism in future definitive studies. |
| first_indexed | 2024-04-12T03:38:05Z |
| format | Article |
| id | doaj.art-ceabd77ce8674247a662afedda8d9fa6 |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-12T03:38:05Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-ceabd77ce8674247a662afedda8d9fa62022-12-22T03:49:21ZengWileyNeuropsychopharmacology Reports2574-173X2021-12-0141452252510.1002/npr2.12202Antinociceptive effects of the combined use of butorphanol and buprenorphine in miceKazumasu Sasaki0Tatsuya Ishikawa1Kazutaka Ikeda2Shinya Kasai3Research Institute for Brain and Blood Vessels Akita Cerebrospinal and Cardiovascular Center Akita JapanResearch Institute for Brain and Blood Vessels Akita Cerebrospinal and Cardiovascular Center Akita JapanAddictive Substance Project Tokyo Metropolitan Institute of Medical Science Tokyo JapanAddictive Substance Project Tokyo Metropolitan Institute of Medical Science Tokyo JapanAbstract Butorphanol and buprenorphine are mixed opioid receptor agonist‐antagonist drugs widely used as analgesics in people and animals. There are few reports concerning the interaction of multiple opioids, and their antinociceptive effects, when combined with other opioids, remain unclear. Therefore, we report the preliminary findings of the antinociceptive effects of the combined use of butorphanol and buprenorphine in C57BL/6JJcl mice. Both drugs were administered either simultaneously or in different orders. Compared with the baseline values, the tail‐flick and hot‐plate test latencies increased regardless of the order of administration. Furthermore, enhanced latencies were observed on administration of butorphanol followed by buprenorphine. Combined use of these drugs may not attenuate analgesic efficacy. Besides, enhancement of these effects can be obtained by changing the order of the administration of these drugs. It is necessary to further investigate the molecular basis of the underlying mechanism in future definitive studies.https://doi.org/10.1002/npr2.12202antinociceptionbuprenorphinebutorphanolmixed opioid receptor agonist‐antagonist |
| spellingShingle | Kazumasu Sasaki Tatsuya Ishikawa Kazutaka Ikeda Shinya Kasai Antinociceptive effects of the combined use of butorphanol and buprenorphine in mice Neuropsychopharmacology Reports antinociception buprenorphine butorphanol mixed opioid receptor agonist‐antagonist |
| title | Antinociceptive effects of the combined use of butorphanol and buprenorphine in mice |
| title_full | Antinociceptive effects of the combined use of butorphanol and buprenorphine in mice |
| title_fullStr | Antinociceptive effects of the combined use of butorphanol and buprenorphine in mice |
| title_full_unstemmed | Antinociceptive effects of the combined use of butorphanol and buprenorphine in mice |
| title_short | Antinociceptive effects of the combined use of butorphanol and buprenorphine in mice |
| title_sort | antinociceptive effects of the combined use of butorphanol and buprenorphine in mice |
| topic | antinociception buprenorphine butorphanol mixed opioid receptor agonist‐antagonist |
| url | https://doi.org/10.1002/npr2.12202 |
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