Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?
Background There is evidence of destructive effects of oxytocin use during labor on neurodevelopment. Purpose This meta-analysis pooled all observational studies to determine the association between labor induction and the risk of attention-deficit/hyperactivity disorder (ADHD) among children. Metho...
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| Format: | Article |
| Language: | English |
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The Korean Pediatric Society
2021-09-01
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| Series: | Clinical and Experimental Pediatrics |
| Subjects: | |
| Online Access: | http://www.e-cep.org/upload/pdf/cep-2020-01557.pdf |
| _version_ | 1818880813086801920 |
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| author | Ensiyeh Jenabi Mahdieh Seyedi Saeid Bashirian Bita Fereidooni |
| author_facet | Ensiyeh Jenabi Mahdieh Seyedi Saeid Bashirian Bita Fereidooni |
| author_sort | Ensiyeh Jenabi |
| collection | DOAJ |
| description | Background There is evidence of destructive effects of oxytocin use during labor on neurodevelopment. Purpose This meta-analysis pooled all observational studies to determine the association between labor induction and the risk of attention-deficit/hyperactivity disorder (ADHD) among children. Methods All observational studies (case-control and cohort) were reviewed until September 2020 after searches of the PubMed, Scopus, and Web of Science databases, the gray literature, and conference proceedings. The pooled odds ratios (ORs), relative ratios (RRs), and 95% confidence intervals (CI (swere calculated as random effect estimates of association among studies. Results All observational studies were reviewed, including 4 cohort studies including 2,885,743 participants and 3 case-control studies including 51,135 participants (10,961 with ADHD and 40,174 in control groups) with a sample size of 2,936,878 participants. The pooled estimates of OR and RR did not indicate a significant association between labor induction and ADHD among children (OR, 1.13; 95% CI, 0.90–1.35) and (RR, 1.10; 95% CI, 0.96–1.24). Conclusions The findings showed that labor induction is not associated with an increased risk of ADHD among children. However, more studies are needed to investigate the relationship between labor induction and ADHD. |
| first_indexed | 2024-12-19T14:51:56Z |
| format | Article |
| id | doaj.art-ceacafc7778443ceb7aa4168163b83f0 |
| institution | Directory Open Access Journal |
| issn | 2713-4148 |
| language | English |
| last_indexed | 2024-12-19T14:51:56Z |
| publishDate | 2021-09-01 |
| publisher | The Korean Pediatric Society |
| record_format | Article |
| series | Clinical and Experimental Pediatrics |
| spelling | doaj.art-ceacafc7778443ceb7aa4168163b83f02022-12-21T20:16:48ZengThe Korean Pediatric SocietyClinical and Experimental Pediatrics2713-41482021-09-0164948949310.3345/cep.2020.0155720125555413Is there an association between labor induction and attention-deficit/hyperactivity disorder among children?Ensiyeh Jenabi0Mahdieh Seyedi1Saeid Bashirian2Bita Fereidooni3 Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran Midwife in Social Security Organization, Hamadan, IranBackground There is evidence of destructive effects of oxytocin use during labor on neurodevelopment. Purpose This meta-analysis pooled all observational studies to determine the association between labor induction and the risk of attention-deficit/hyperactivity disorder (ADHD) among children. Methods All observational studies (case-control and cohort) were reviewed until September 2020 after searches of the PubMed, Scopus, and Web of Science databases, the gray literature, and conference proceedings. The pooled odds ratios (ORs), relative ratios (RRs), and 95% confidence intervals (CI (swere calculated as random effect estimates of association among studies. Results All observational studies were reviewed, including 4 cohort studies including 2,885,743 participants and 3 case-control studies including 51,135 participants (10,961 with ADHD and 40,174 in control groups) with a sample size of 2,936,878 participants. The pooled estimates of OR and RR did not indicate a significant association between labor induction and ADHD among children (OR, 1.13; 95% CI, 0.90–1.35) and (RR, 1.10; 95% CI, 0.96–1.24). Conclusions The findings showed that labor induction is not associated with an increased risk of ADHD among children. However, more studies are needed to investigate the relationship between labor induction and ADHD.http://www.e-cep.org/upload/pdf/cep-2020-01557.pdfattention deficit disorder with hyperactivitylabor inductionmeta-analysis |
| spellingShingle | Ensiyeh Jenabi Mahdieh Seyedi Saeid Bashirian Bita Fereidooni Is there an association between labor induction and attention-deficit/hyperactivity disorder among children? Clinical and Experimental Pediatrics attention deficit disorder with hyperactivity labor induction meta-analysis |
| title | Is there an association between labor induction and attention-deficit/hyperactivity disorder among children? |
| title_full | Is there an association between labor induction and attention-deficit/hyperactivity disorder among children? |
| title_fullStr | Is there an association between labor induction and attention-deficit/hyperactivity disorder among children? |
| title_full_unstemmed | Is there an association between labor induction and attention-deficit/hyperactivity disorder among children? |
| title_short | Is there an association between labor induction and attention-deficit/hyperactivity disorder among children? |
| title_sort | is there an association between labor induction and attention deficit hyperactivity disorder among children |
| topic | attention deficit disorder with hyperactivity labor induction meta-analysis |
| url | http://www.e-cep.org/upload/pdf/cep-2020-01557.pdf |
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